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| 1 | Positron emission tomography to assess hypoxia and perfusion in lung cancer显示文摘In lung cancer, tumor hypoxia is a characteristic feature, which is associated with a poor prognosis and resistance to both radiation therapy and chemotherapy. As the development of tumor hypoxia is associated with decreased perfusion, perfusion measurements provide more insight into the relation between hypoxia and perfusion in malignant tumors. Positron emission tomography(PET) is a highly sensitive nuclear imaging technique that is suited for non-invasive in vivo monitoring of dynamic processes including hypoxia and its associated parameter perfusion. The PET technique enables quantitative assessment of hypoxia and perfusion in tumors. To this end, consecutive PET scans can be performed in one scan session. Using different hypoxia tracers, PET imaging may provide insight into the prognostic significance of hypoxia and perfusion in lung cancer. In addition, PET studies may play an important role in various stages of personalized medicine, as these may help to select patients for specifictreatments including radiation therapy, hypoxia modifying therapies, and antiangiogenic strategies. In addition, specific PET tracers can be applied for monitoring therapy. The present review provides an overview of the clinical applications of PET to measure hypoxia and perfusion in lung cancer. Available PET tracers and their characteristics as well as the applications of combined hypoxia and perfusion PET imaging are discussed. | Eline E Verwer Ronald Boellaard Astrid AM van der Veldt | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 2 | Mutans streptococci in subgingival plaque of treated and untreated patients with periodontitis显示文摘 | Van der Reijden WA Dellemijn Kippuw N Stijne-van Nes AM | 2001 | J Clin Periodontol2001，28，7： | 1 |
| 3 | Gene therapy with apoptin induces regression of xenografted human hepatomas 显示文摘 | Van der Eb MM Pietersen AM Speetjens FM | 2002 | Cancer Gene Ther2002，9，1： | 1 |
| 4 | Causes of death--other than progressive leukemia--in childhood acute lymphoblastic(ALL) and myeloid leukemia (AML):the Dutch Childhood Oncology Group experience显示文摘 | Slats AM Egeler RM van der Does-van den Berg A | | 0，，： | 1 |
| 5 | Rec- ognition of facial emotion and affective prosody in children with ASD (-ADHD) and their unaffected siblings显示文摘 | Oerlemans AM van der Meer JM van Steijn DJ | 2014 | Eur Child Adolesc Psychiatry2014，23，5： | 1 |
| 6 | Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes显示文摘 | Manschot SM Brands AM van der Grond J | 2006 | Diabete2006，55，4： | 1 |
| 7 | MIP-3a/CCL20 in renal transplantation and its possible involvement as dendritic cell chemoattractant in allograft rejection显示文摘 | Woltmana AM de Fijtera JW van der Kooija SW | 2005 | AmerJ Transplant2005，5，： | 1 |
| 8 | The AO/ASIF-proximail femoral nail (PFN):a new device for the treatment of unstable proximal femoral fractures显示文摘 | Simmermacher RK Bosch AM Van der Werken C | | 0，，5： | 1 |
| 9 | Decreased E47 in senescent B cell precursors is stage specific and regulated post- translationally by protein turnover显示文摘 | Van der Put E Frasca D King AM | 2004 | J Immunol2004，173，2： | 1 |
| 10 | Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition 显示文摘 | van der Aar AM Sylva-SteenLand RM Bos JD | 2007 | J Immunol2007，178，4： | 1 |
| 11 | Rhokinase-dependent F-actin rearrangement is involved in the inhibition of PI3-Ki- nase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis显示文摘 | Van der He Den M Versteilen AM | 2008 | Apoptosis2008，13，： | 1 |
| 12 | Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN- gamma显示文摘 | de Bruin AM Buitenhuis M van der Sluijs KF | 2010 | Blood2010，116，14： | 1 |
| 13 | Accelerated Notch- dependent degradation of E47 proteins in aged B cell precursors is associated with increased ERK MAPK activation 显示文摘 | King AM Van der Put E Blomberg BB | 2007 | J Immunol2007，178，6： | 1 |
| 14 | Pim1 regulates androgen-dependent survival signaling in prostate cancer cells显示文摘 | van der Poel HG Zevenhoven J Bergman AM | | 0，，02： | 1 |
| 15 | Mechanical properties of suspended graphene sheets显示文摘 | IW Frank DM Tanenbaum Van der Zande AM | 2007 | Journal of Vacuum Science2007，25，6： | 1 |
| 16 | Transcriptional down-regulation of peroxisome numbers affects slective peroxisome degradation in Hansenula polymorpha显示文摘 | Leao-Helder AN Krikken AM van der Klei IJ | 2003 | J Biol Chem2003，42，40： | 1 |
| 17 | Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes显示文摘 | Manschot SM Brands AM van der Grond J | 2006 | Diabetes2006，55，4： | 1 |
| 18 | Rapid and efficient cancer cell killing mediated by high-affin- ity death receptor homotrimerizing TRAIL variants显示文摘 | Reis CR van der Sloot AM Natoni A | 2010 | Cell Death Dis2010，，1： | 1 |
| 19 | The AO/ASIF proximal femoral nail (PFN) : a new device for the treatment of unstable proximal femoral fractures 显示文摘 | Simmermacher RK Bosch AM van der Werken C | 1999 | Injury1999，30，5： | 1 |
| 20 | Changes in L-selection expression on CD34-positive cells upon cryopreservation of peripheral blood stem cell transplants显示文摘 | Drager AM van der WE | 1998 | Bone Marrow Transplant1998，22，： | 1 |
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