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| 1 | Expression changes and bioinformatic analysis of Wallerian degeneration after sciatic nerve injury in rat显示文摘Wallerian degeneration (WD) remains an important research topic. Many genes are differentially expressed during the process of WD, but the precise mechanisms responsible for these differentiations are not completely understood. In this study, we used microarrays to analyze the expression changes of the distal nerve stump at 0, 1, 4, 7, 14, 21 and 28 days after sciatic nerve injury in rats. The data revealed 6 076 differentially-expressed genes, with 23 types of expression, specifically enriched in genes associated with nerve development and axonogenesis, cytokine biosynthesis, cell differentiation, cytokine/chemokine production, neuron differentiation, cytokinesis, phosphorylation and axon regeneration. Kyoto Encyclopedia of Genes and Genomes pathway analysis gave findings related mainly to the MAPK signaling pathway, the Jak-STAT signaling pathway, the cell cycle, cytokine-cytokine receptor interaction, the p53 signaling pathway and the Wnt signaling pathway. Some key factors were NGF, MAG, CNTF, CTNNA2, p53, JAK2, PLCB1, STAT3, BDNF, PRKC, collagen II, FGF, THBS4, TNC and c-Src, which were further validated by real-time quantitative PCR, Western blot, and immunohistochemistry. Our findings contribute to a better understanding of the functional analysis of differentially-expressed genes in WD and may shed light on the molecular mechanisms of nerve degeneration and regeneration. | Dengbing Yao Meiyuan Li Dingding Shen Fei Ding Shibi Lu Qing Zhao Xiaosong Gu | 2013 | Neuroscience Bulletin2013，29，3： | 18 |
| 2 | Identification and functional annotation of novel microRNAs in the proximal sciatic nerve after sciatic nerve transection显示文摘The peripheral nervous system is able to regenerate after injury, and regeneration is associated with the expression of many genes and proteins. MicroRNAs are evolutionarily conserved, small, non-coding RNA molecules that regulate gene expression at the level of translation. In this paper, we focus on the identification and functional annotation of novel microRNAs in the proximal sciatic nerve after rat sciatic nerve transection. Using Solexa sequencing, computational analysis, and quantitative reverse transcription PCR verification, we identified 98 novel microRNAs expressed on days 0, 1, 4, 7, and 14 after nerve transection. Furthermore, we predicted the target genes of these microRNAs and analyzed the biological processes in which they were involved. The identified biological processes were consistent with the known time-frame of peripheral nerve injury and repair. Our data provide an important resource for further study of the role and regulation of microRNAs in peripheral nerve injury and regeneration. | LI ShiYing YU Bin WANG YongJun YAO DengBing ZHANG ZhanHu GU XiaoSong | 2011 | Science China(Life Sciences)2011，54，9： | 16 |
| 3 | The effects of claudin 14 during early Wallerian degeneration after sciatic nerve injury显示文摘Claudin 14 has been shown to promote nerve repair and regeneration in the early stages of Wallerian degeneration(0–4 days) in rats with sciatic nerve injury, but the mechanism underlying this process remains poorly understood. This study reported the effects of claudin 14 on nerve degeneration and regeneration during early Wallerian degeneration. Claudin 14 expression was up-regulated in sciatic nerve 4 days after Wallerian degeneration. The altered expression of claudin 14 in Schwann cells resulted in expression changes of cytokines in vitro. Expression of claudin 14 affected c-Jun, but not Akt and ERK1/2 pathways. Further studies revealed that enhanced expression of claudin 14 could promote Schwann cell proliferation and migration. Silencing of claudin 14 expression resulted in Schwann cell apoptosis and reduction in Schwann cell proliferation. Our data revealed the role of claudin 14 in early Wallerian degeneration, which may provide new insights into the molecular mechanisms of Wallerian degeneration. | Leilei Gong Yun Zhu Xi Xu Huaiqin Li Weimin Guo Qin Zhao Dengbing Yao | 2014 | Neural Regeneration Research2014，9，24： | 7 |
| 4 | Differential gene expression in proximal and distal nerve segments of rats with sciatic nerve injury during Wallerian degeneration显示文摘Wallerian degeneration is a subject of major interest in neuroscience. A large number of genes are differentially regulated during the distinct stages of Wallerian degeneration: transcription factor activation, immune response, myelin cell differentiation and dedifferentiation. Although gene expression responses in the distal segment of the sciatic nerve after peripheral nerve injury are known, differences in gene expression between the proximal and distal segments remain unclear. In the present study in rats, we used microarrays to analyze changes in gene expression, biological processes and signaling pathways in the proximal and distal segments of sciatic nerves undergoing Wallerian degeneration. More than 6,000 genes were differentially expressed and 20 types of expression tendencies were identified, mainly between proximal and distal segments at 7–14 days after injury. The differentially expressed genes were those involved in cell differentiation, cytokinesis, neuron differentiation, nerve development and axon regeneration. Furthermore, 11 biological processes were represented, related to responses to stimuli, cell apoptosis, inflammatory response, immune response, signal transduction, protein kinase activity, and cell proliferation. Using real-time quantitative PCR, western blot analysis and immunohistochemistry, microarray data were verified for four genes: aquaporin-4, interleukin 1 receptor-like 1, matrix metalloproteinase-12 and periaxin. Our study identifies differential gene expression in the proximal and distal segments of a nerve during Wallerian degeneration, analyzes dynamic biological changes of these genes, and provides a useful platform for the detailed study of nerve injury and repair during Wallerian degeneration. | Nan Jiang Huaiqin Li Yi Sun Dexin Yin Qin Zhao Shusen Cui Dengbing Yao | 2014 | Neural Regeneration Research2014，9，12： | 5 |
| 5 | Gene expression profiling of the rat sciatic nerve in early Wallerian degeneration after injury显示文摘Wallerian degeneration is an important area of research in modern neuroscience.A large number of genes are differentially regulated in the various stages of Wallerian degeneration,especially during the early response.In this study,we analyzed gene expression in early Wallerian degeneration of the distal nerve stump at 0,0.5,1,6,12 and 24 hours after rat sciatic nerve injury using gene chip microarrays.We screened for differentially-expressed genes and gene expression patterns.We examined the data for Gene Ontology,and explored the Kyoto Encyclopedia of Genes and Genomes Pathway.This allowed us to identify key regulatory factors and recurrent network motifs.We identified 1 546 differentially-expressed genes and 21 distinct patterns of gene expression in early Wallerian degeneration,and an enrichment of genes associated with the immune response,acute inflammation,apoptosis,cell adhesion,ion transport and the extracellular matrix.Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed components involved in the Jak-STAT,ErbB,transforming growth factor-β,T cell receptor and calcium signaling pathways.Key factors included interleukin-6,interleukin-1,integrin,c-sarcoma,carcinoembryonic antigen-related cell adhesion molecules,chemokine(C-C motif) ligand,matrix metalloproteinase,BH3 interacting domain death agonist,baculoviral IAP repeat-containing 3 and Rac.The data were validated with real-time quantitative PCR.This study provides a global view of gene expression profiles in early Wallerian degeneration of the rat sciatic nerve.Our findings provide insight into the molecular mechanisms underlying early Wallerian degeneration,and the regulation of nerve degeneration and regeneration. | Dengbing Yao Meiyuan Li Dingding Shen Fei Ding Shibi Lu Qin Zhao Xiaosong Gu | 2012 | Neural Regeneration Research2012，7，17： | 5 |
| 6 | High-performance liquid chromatographic determination foraris- tolochic acid in medicinal plants and slimming products 显示文摘 | LEE T Y WUB M L DENGB J F | 2001 | Journal of Chromatography B2001，，766： | 1 |
| 7 | 显示文摘 | ChenGY DengB CaiGB | 2008 | J PhysChem C2008，112，16： | 1 |
| 8 | Effect of pretreatmentprotocols on human amniotic fluid protein profiling withSELDI-TOF MS using protein chips and magnetic beads显示文摘 | DENGB DONG Z LIU Y | 2010 | Clinica Chimica Acta2010，411，1516： | 1 |
| 9 | Resveratrolprotectsvascularen-dothelialcellsfromhighglucose-inducedapoptosisthroughinhibi-tionofNADPHoxidaseactivation-drivenoxidativestress显示文摘 | ChenF QianLH DengB etal | 2013 | CNSNeurosciTher2013，19，9： | 1 |
| 10 | Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects显示文摘 | HanJR DengB Sun J etal | 2007 | Metabolism2007，56，： | 1 |
| 11 | Effects of dietary medium--chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free--living type--diabetic Chinese subjects显示文摘 | Flan JR Dengb Sun J | 2007 | Metabolism2007，56，7： | 1 |
| 12 | Influence of particle size, density, particle concentration on bend e- rosive wear in pneumatic conveyors显示文摘 | Macchinia R Bradleyb M S A Dengb T | 2013 | Wear2013，303，3： | 1 |
| 13 | Selective Synthesisof Vanadium Oxides and Investigation of the ThermochromicProperties of VO2 by Infrared Spectroscopy显示文摘 | Li Ming Li Dengbing Pan Jing | 2013 | Eur JInorg Chem2013，，7： | 1 |
| 14 | Selective synthesis of vanadium oxides and investigation of the thermochromic properties of VO2 by infrared spectroscopy显示文摘 | Li Ming Li Dengbing Pan Jing | 2013 | European Journal of Inorganic Chemistry2013，2013，7： | 1 |
| 15 | Self‐training maximum classifier discrepancy for EEG emotion recognition显示文摘Even with an unprecedented breakthrough of deep learning in electroencephalography(EEG),collecting adequate labelled samples is a critical problem due to laborious and time‐consuming labelling.Recent study proposed to solve the limited label problem via domain adaptation methods.However,they mainly focus on reducing domain discrepancy without considering task‐specific decision boundaries,which may lead to feature distribution overmatching and therefore make it hard to match within a large domain gap completely.A novel self‐training maximum classifier discrepancy method for EEG classification is proposed in this study.The proposed approach detects samples from a new subject beyond the support of the existing source subjects by maximising the discrepancies between two classifiers'outputs.Besides,a self‐training method that uses unlabelled test data to fully use knowledge from the new subject and further reduce the domain gap is proposed.Finally,a 3D Cube that incorporates the spatial and frequency information of the EEG data to create input features of a Convolutional Neural Network(CNN)is constructed.Extensive experiments on SEED and SEED‐IV are conducted.The experimental evaluations exhibit that the proposed method can effectively deal with domain transfer problems and achieve better performance. | Xu Zhang Dengbing Huang Hanyu Li Youjia Zhang Ying Xia Jinzhuo Liu | 2023 | CAAI Transactions on Intelligence Technology2023，8，4： | 1 |
| 16 | Clinlcal value of assaying tumor supplied group of factor/tumor specific growth factor in patients with solitary pulmonary nodule显示文摘 | DengB TanQY FanXQ | 2011 | Clin Lung Cancer2011，12，3： | 1 |
| 17 | Flexural creep behavior of sandwich panels containing kraft paper honeycomb core and wood composite skins 显示文摘 | Zheng Chena Ning Yana James Dengb | 2011 | Materials Science and Engineering A2011，528，： | 1 |
| 18 | Almost sure and moment exponen-tial stability of Euler-Maruyama discretizations for hybrid stochastic differential equations显示文摘 | Mao X Pang S Dengb F | 2008 | Journal of Computational and Applied Mathematics2008，213，： | 1 |
| 19 | Improving the Performance of PbS Quantum Dot Solar Cells by Optimizing ZnO Window Layer显示文摘Comparing with hot researches in absorber layer,window layer has attracted less attention in PbS quantum dot solar cells(QD SCs). Actually, the window layer plays a key role in exciton separation, charge drifting, and so on.Herein, ZnO window layer was systematically investigated for its roles in QD SCs performance. The physical mechanism of improved performance was also explored. It was found that the optimized ZnO films with appropriate thickness and doping concentration can balance the optical and electrical properties, and its energy band align well with the absorber layer for efficient charge extraction. Further characterizations demonstrated that the window layer optimization can help to reduce the surface defects, improve the heterojunction quality, as well as extend the depletion width. Compared with the control devices, the optimized devices have obtained an efficiency of 6.7% with an enhanced V_(oc) of 18%, J_(sc) of 21%, FF of 10%, and power conversion efficiency of 58%. The present work suggests a useful strategy to improve the device performance by optimizing the window layer besides the absorber layer. | Xiaokun Yang Long Hu Hui Deng Keke Qiao Chao Hu Zhiyong Liu Shengjie Yuan Jahangeer Khan Dengbing Li Jiang Tang Haisheng Song Chun Cheng | 2017 | Nano-Micro Letters2017，9，2： | 0 |
| 20 | Role of transforming growth factor-βin peripheral nerve regeneration显示文摘Injuries caused by trauma and neurodegenerative diseases can damage the peripheral nervous system and cause functional deficits.Unlike in the central nervous system,damaged axons in peripheral nerves can be induced to regenerate in response to intrinsic cues after reprogramming or in a growth-promoting microenvironment created by Schwann cells.However,axon regeneration and repair do not automatically result in the restoration of function,which is the ultimate therapeutic goal but also a major clinical challenge.Transforming growth factor(TGF)is a multifunctional cytokine that regulates various biological processes including tissue repair,embryo development,and cell growth and differentiation.There is accumulating evidence that TGF-βfamily proteins participate in peripheral nerve repair through various factors and signaling pathways by regulating the growth and transformation of Schwann cells;recruiting specific immune cells;controlling the permeability of the blood-nerve barrier,thereby stimulating axon growth;and inhibiting remyelination of regenerated axons.TGF-βhas been applied to the treatment of peripheral nerve injury in animal models.In this context,we review the functions of TGF-βin peripheral nerve regeneration and potential clinical applications. | Zihan Ding Maorong Jiang Jiaxi Qian Dandan Gu Huiyuan Bai Min Cai Dengbing Yao | 2024 | Neural Regeneration Research2024，19，2： | 0 |
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