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| 1 | Isolation and characterization of Zika virus imported to China using C6/36 mosquito cells显示文摘Dear Editor,Zika virus(ZIKV)is a mosquito-borne flavivirus that usually causes asymptomatic infections or mild illness in humans.However,the unprecedented epidemics of ZIKV in Latin America since early 2015 have made this flavivirus an international health risk(Liu and Zhang,2016).In particular,the potential association of ZIKV infection with the remarkable increase in the number | Chenglin Deng Siqing Liu Qiuyan Zhang Mingyue Xu Honglei Zhang Dayong Gu Lei Shi Jian'an He Gengfu Xiao Bo Zhang | 2016 | Virologica Sinica2016，31，2： | 12 |
| 2 | A Novel Approach to Automatic Security Protocol Analysis Based on Authentication Event Logic显示文摘Since security protocols form the cornerstones of modern secure networked systems, it is important to develop informative, accurate, and deployable approach for finding errors and proving that protocols meet their security requirements. We propose a novel approach to check security properties of cryptographic protocols using authentication event logic. Compared with logic of algorithm knowledge, authentication event logic guarantees that any well-typed protocol is robustly safe under attack while reasoning only about the actions of honest principals in the protocol. It puts no bound on the size of the principal and requires no state space enumeration and it is decidable. The types for protocol data provide some intuitive explanation of how the protocol works. Our approach has led us to the independent rediscovery of flaws in existing protocols and to the design of improved protocols. | XIAO Meihua MA Chenglin DENG Chunyan ZHU Ke | 2015 | Chinese Journal of Electronics2015，24，1： | 10 |
| 3 | Development and characterization of a clinical strain of Coxsackievirus A16 and an eGFP infectious clone显示文摘Coxsackievirus A16(CA16) is one of the major causes of hand, foot, and mouth disease(HFMD) worldwide, which is a common illness that affects children. The frequent occurrence of HFMD outbreaks has become a serious public health problem in Asia. Therefore, it is important to understand the pathogenesis and replication of CA16. In this study, a stable infectious c DNA clone of an epidemic strain of Coxsackievirus A16(CA16) was assembled, and subsequently a reporter virus(e GFP-CA16) was constructed by inserting the e GFP gene between the 5'-UTR and the N-terminus of VP4, with the addition of a 2A protease cleavage site(ITTLG) at its C-terminus. This was transfected into Vero cells to generate infectious recombinant viruses. The growth characteristics and plaque morphology, in vitro, in mammalian cells were found to be indistinguishable between the parental and recombinant viruses. Although the e GFP-CA16 showed smaller plaque size as compared to recombinant CA16, both were found to exhibit similar growth trends and EC50 of NITD008. In summary, this stable infectious c DNA clone should provide a valuable experimental system to study CA16 infection and host response. The e GFP-CA16 is expected to provide a powerful tool to monitor e GFP expression in infected cells and to evaluate the antiviral activity of potential antiviral agents in the treatment of CA16 infections. | Chenglin Deng Xiaodan Li Siqing Liu Linlin Xu Hanqing Ye Cheng-Feng Qin Bo Zhang | 2015 | Virologica Sinica2015，30，4： | 5 |
| 4 | Trans Complementation of Replication-defective Omsk Hemorrhagic Fever Virus for Antiviral Study显示文摘Omsk hemorrhagic fever virus(OHFV) is a tick-borne flavivirus classified as a biosafety level-4(BSL4) pathogen. Studies of OHFV are restricted to be conducted within BSL4 laboratories. Currently, no commercial vaccines or antiviral drugs are available against OHFV infection. In this study, we recovered a replication-deficient OHFV with an NS1 deletion(OHFVDNS1) and reporter virus replacing NS1 with the Gaussia luciferase(Gluc)(OHFV-ΔNS1-Gluc). Both the defective OHFVDNS1 and OHFV-ΔNS1-Gluc virus could only replicate efficiently in the BHK21 cell line expressing NS1(BHK21NS1) but not in na?ve BHK21 cells. The Gluc reporter gene of OHFV-ΔNS1-Gluc virus was maintained stably after serial passaging of BHK21NS1 cells and was used to surrogate the replication of OHFV. Using NITD008, OHFV-ΔNS1-Gluc virus was validated for antiviral screening, and high-throughput screening parameters were optimized in a 96-well plate format with a calculated Z0 value above 0.5. The OHFV-ΔNS1-Gluc reporter virus is a powerful tool for antiviral screening as well as viral replication and pathogenesis studies in BSL2 laboratories. | Qiuyan Zhang Na Li Chenglin Deng Zherui Zhang Xiaodan Li Kentaro Yoshii Hanqing Ye Bo Zhang | 2019 | Virologica Sinica2019，34，4： | 4 |
| 5 | Tunable optical frequency comb from a compact and robust Er:fiber laser显示文摘We report on a compact and robust self-referenced optical frequency comb with a tunable repetition rate,generated by an all-polarization-maintaining(PM)mode-locked Er-doped fiber laser.The spacing between comb teeth can be tuned above 300 kHz at a repetition rate of 101 MHz.The repetition rate and the carrier-envelope offset of the laser are stabilized separately,and the relative residual phase noises are determined to be 336µrad and 713 mrad(1 Hz-1 MHz).The accurate frequency characteristics and the stable structure show great potential for the use of such a comb in applications of precision measurements. | Zhiwei Zhu Yang Liu Daping Luo Chenglin Gu Lian Zhou Gehui Xie Zejiang Deng Wenxue Li | 2020 | High Power Laser Science and Engineering2020，8，2： | 2 |
| 6 | EFFECTS OF INJECTION STRATEGY ON D.I. DIESEL ENGINE COMBUSTION显示文摘Experiments are conducted to develop an understanding of how split injections can affect the combustion and emission characteristics of a D.I. diesel engine with a common-rail injection system. The ratio of the amount of fuel injected between two injection pulses and the injection interval is varied keeping the injected fuel quantity constant. Results show that under the 70D90-10 injection pattern, the engine achieves the lower NOx-smoke emissions and BSFC compared with the single injection pattern. The heat release rate and the temperature show that the split injections increase the initial premixed burn and retards the diffusion burn. With the balance of these two effects, the maximum in-cylinder temperature decreases while the 50% heat release point is held at almost the same crank angle. Therefore, both NOx emission and BSFC are improved while keeping the smoke emission at the same level. | ZI Xinyun JIANG Dahai DENG Chenglin OUYANG Minggao YANG Fuyuan | 2007 | Chinese Journal of Mechanical Engineering2007，20，3： | 2 |
| 7 | Hierarchically Designed SiOx/SiOy Bilayer Nanomembranes as Stable Anodes for Lithium Ion Batteries显示文摘 | Lin Zhang Junwen Deng Lifeng Liu Wenping Si Steffen Oswald Lixia Xi Manab Kundu Guozhi Ma Thomas Gemming Stefan Baunack Fei Ding Chenglin Yan Oliver G. Schmidt | 2014 | Adv Mater2014，，26： | 1 |
| 8 | FLOW CHARACTERISTICS OF WALLFLOW DIESEL PARTICULATE FILTER SYSTEM WITH REVERSE PULSE AIR REGENERATION显示文摘To simulate steady airflows inside of wall-flow diesel paniculate filters (DPF) with differentreverse blowing pipes collocation, a mathematical model of the flow in a DPF is established by anequivalent continuum approach. The experimental results agree well with the theoretical values calcu-lated from the model. Simulation shows that the velocity and the pressure distribution of the filters inthe regenerative process are key factors to the filter’s regeneration. How to decrease themal-distribution of the flow in the filter and how to achieve the better regenerative performance at theleast cost of air consumption in the regenerative process are the ultimate goals of the study. Calculationand experiments show that the goals can be realized through adjusting the angle of two reverse blowingpipes and their relative location suitably. | Yao Chunde Shao Yuping Zhang Chunrun Zi XinYun Jiang Dahai Deng Chenglin | 2005 | Chinese Journal of Mechanical Engineering2005，18，3： | 1 |
| 9 | Long-term trend of visibility and its characterizations in the Pearl River Delta (PRD) region, China显示文摘 | Xuejiao Deng Xuexi Tie Dui Wu Xiuji Zhou Xueyan Bi Hanbo Tan Fei Li Chenglin Jiang | 2007 | Atmospheric Environment2007，，7： | 1 |
| 10 | Development and Characterization of West Nile Virus Replicon Expressing Secreted Gaussia Luciferase显示文摘We developed a Gaussia luciferase (Gluc) reporter replicon of West Nile virus (WNV) and used it to quantify viral translation and RNA replication. The advantage of the Gluc replicon is that Gaussia luciferase is secreted into the culture medium from cells transfected with Gluc replicon RNA, and the medium can be assayed directly for luciferase activity. Using a known Flavivirus inhibitor (NITD008), we demonstrated that the Gluc-WNV replicon could be used for antiviral screening. The Gluc-WNV-Rep will be useful for research in antiviral drug development programs, as well as for studying viral replication and pathogenesis of WNV. | Chao Shan Xiaodan Li Chenglin Deng Baodi Shang Linlin Xu Hanqing Ye Zhiming Yuan Bo Zhang | 2013 | Virologica Sinica2013，28，3： | 1 |
| 11 | Optimizing noise characteristics of mode-locked Yb-doped fiber laser using gain-induced RIN-transfer dynamics显示文摘Gain-parameter-dependent transfer functions and phase-noise performances in a mode-locked Yb-doped fiber laser are measured in this study.It is discovered that the corner frequency in the amplitude and phase domains is determined by the absorption coefficient of the gain fiber,when the total absorption and other cavity parameters are fixed.This shows that an oscillator using gain fiber with higher dopant concentration accumulates more phase noise.Furthermore,we present net cavity dispersion-dependent transfer functions to verify the effect of dispersion management on the frequency response.We derive a guideline for optimizing mode-locked fiber laser design to achieve low phase noise and timing jitter. | Jiangshuoxue Han Yang Liu Zejiang Deng Gehui Xie Daping Luo Chenglin Gu Lian Zhou Wenxue Li | 2021 | High Power Laser Science and Engineering2021，9，3： | 1 |
| 12 | Long-term trend of visibility and its characterizations in the Pearl River Delta (PRD) region, China显示文摘 | Xuejiao Deng Xuexi Tie Dui Wu Xiuji Zhou Xueyan Bi Hanbo Tan Fei Li Chenglin Jiang | 2007 | Atmospheric Environment2007，，7： | 1 |
| 13 | Mid-infrared optical frequency comb in the 2.7-4.0μm range via difference frequency generation from a compact laser system显示文摘We report on the generation of a mid-infrared(mid-IR)frequency comb with a maximum average output power of250 mW and tunability in the 2.7-4.0μm region.The approach is based on a single-stage difference frequency generation(DFG)starting from a compact Yb-doped fiber laser system.The repetition rate of the near-infrared(NIR)comb is locked at 75 MHz.The phase noise of the repetition rate in the offset-free mid-IR comb system is measured and analyzed.Except for the intrinsic of NIR comb,environmental noise at low frequency and quantum noise at high frequency from the amplifier chain and nonlinear spectral broadening are the main noise sources of broadening the linewidth of comb teeth,which limits the precision of mid-IR dual-comb spectroscopy. | Lian Zhou Yang Liu Gehui Xie Chenglin Gu Zejiang Deng Zhiwei Zhu Cheng Ouyang Zhong Zuo Daping Luo Bin Wu Kunfeng Chen Wenxue Li | 2020 | High Power Laser Science and Engineering2020，8，4： | 1 |
| 14 | Long-term trend of visibility and its characterizations in the Pearl River Delta (PRD) region, China显示文摘 | Xuejiao Deng Xuexi Tie Dui Wu Xiuji Zhou Xueyan Bi Hanbo Tan Fei Li Chenglin Jiang | 2007 | Atmospheric Environment2007，，7： | 1 |
| 15 | Experimental study on unfrozen water content and soil matric potential of Qinghai-Tibetan silty clay显示文摘 | Zhi Wen Wei Ma Wenjie Feng Yousheng Deng Dayan Wang Zhaosheng Fan Chenglin Zhou | 2012 | Environmental Earth Sciences2012，，5： | 1 |
| 16 | Design and experiments of a small resonant inchworm piezoelectric robot显示文摘A small resonant inchworm piezoelectric robot with six driving feet which are set evenly along the circumference is proposed and tested.A bonded-type structure is adopted to realize a small size.The radial bending vibration mode and longitudinal vibration mode are excited at the same frequency.The superposition of these two vibration modes makes the driving feet produce elliptical motions.And the driving force can be generated by friction coupling between the driving foot and the operating plane.The structure of the robot is designed by finite element simulation.The geometric parameters are adjusted to make the resonant frequencies of the vibration modes as close as possible.The elliptical trajectories generated at the driving feet are discussed in detail.The vibration and motion characteristics of the prototype are tested,and the resonant frequencies of the radial bending mode and the longitudinal vibration mode are degenerated successfully.The optimal working frequency of the prototype is 21.5 kHz.The maximum speed of the prototype is 200 mm/s,and the displacement resolution is 0.71μm.The measured results show that the resonant inchworm piezoelectric robot can be used for fast and high-precision transportation in narrow space. | DENG Jie YANG ChengLin LIU YingXiang ZHANG ShiJing LI Jing MA XueFeng XIE Hui | 2023 | Science China(Technological Sciences)2023，66，3： | 0 |
| 17 | Oridonin inhibits SARS-CoV-2 replication by targeting viral proteinase and polymerase显示文摘COVID-19 has become a global public health crisis since its outbreak in China in December 2019.Currently there are few clinically effective drugs to combat SARS-CoV-2 infection.The main protein(M^(pro)),papain-like protease(PL^(pro))and RNA-dependent RNA polymerase(RdRp)of SARS-CoV-2 are involved in the viral replication,and might be prospective targets for anti-coronavirus drug development.Here,we investigated the antiviral activity of oridonin,a natural small-molecule compound,against SARS-CoV-2 infection in vitro.The time-of-addition analysis showed that oridonin efficiently inhibited SARS-CoV-2 infection by interfering with the genome replication at the post-entry stage.Mechanistically,the inhibition of viral replication by oridonin depends on the oxidation activity ofα,β-unsaturated carbonyl.Further experiments showed that oridonin not only effectively inhibited SARS-CoV-2 Mpro activity,but also had some inhibitory effects on PLpro-mediated deubiquitinating and viral polymerase-catalyzed RNA elongation activities at high concentrations.In particular,oridonin could inhibit the bat SARS-like CoV and the newly emerged SARS-CoV-2 omicron variants(BA.1 and BA.2),which highlights its potential as a pan-coronavirus antiviral agent.Overall,our data provide strong evidence that oridonin is an efficient antiviral agent against SARS-CoV-2 infection. | Zherui Zhang Hongqing Zhang Yanan Zhang Qiuyan Zhang Qiaojie Liu Yanyan Hu Xiaoling Chen Jing Wang Yujia Shi Chenglin Deng Peng Gong Bo Zhang Xiaodan Li Bing Zhu Hanqing Ye | 2023 | Virologica Sinica2023，38，3： | 0 |
| 18 | Li^(+)-ion bound crown ether functionalization enables dual promotion of dynamics and thermodynamics for ambient ammonia synthesis显示文摘Electrosynthesis of ammonia from the reduction of nitrogen is still confronted with the limited supply of gas reactant in dynamics as well as high activation barrier in thermodynamics.Unfortunately,despite tremendous efforts devoted to electrocatalysts themselves,they still fail to tackle the above two challenges simultaneously.Herein,we employ a heterogeneous catalyst adlayer-composed of crown ethers associated with Li^(+)ions-to achieve the dual promotion of dynamics and thermodynamics for ambient ammonia synthesis.Dynamically,the bound Li^(+)ions interact with the strong quadrupole moment of nitrogen,and trigger considerable reactant flux toward the catalyst.Thermodynamically,Li^(+)associated with the oxygen of crown ether achieves a higher density of states at the Fermi level for the catalyst,enabling effortless electron transfer from the catalysts to nitrogen and thus greatly reducing the activation barrier.As expected,the proof-of-concept system achieves an ammonia yield rate of 168.5μg h^(-1)mg^(-1)and a Faradaic efficiency of 75.3%at-0.3 V vs.RHE.This system-level approach opens up pathways for tackling the two key challenges that have limited the field of ammonia synthesis. | Qiyang Cheng Sisi Liu Mengfan Wang Lifang Zhang Yanzheng He Jiajie Ni Jingru Zhang Chengwei Deng Yi Sun Tao Qian Chenglin Yan | 2023 | Journal of Energy Chemistry2023，，10： | 0 |
| 19 | Workshop Discussions:On'The Grieved Dance,''Wooden Radio'&'The Vanilla Camp'显示文摘Xudong Zhang:We all encounter this problem when we read early avant・garde works:Although the reading itself is enjoyable,we still want to figure out the exact meanings of the text.I discussed this question with Su Tong蘇童on our way here,and he agreed that this is true when reading short stories・I will invite him to say a few more words on the subject later. | Xudong ZHANG Su Tong Cong Zhou Jing Wang Shiqi Liao Zijian TAN Yue PU Honey Watson Todd Foley Chenglin YU Chao DENG Hanchi LÜ Tairan LI Jinyi CHU Han Zhuyuan(Translated) | 2020 | Frontiers of Literary Studies in China-Selected Publications from Chinese Universities2020，14，3： | 0 |
| 20 | Tunable compact asynchronous optical sampling system using Er-doped fiber laser显示文摘We report a compact,tunable,self-starting,all-fiber laser-based asynchronous optical sampling(ASOPS)system.Two Er-doped fiber oscillators were used as the pulsed-laser source,whose repetition rate could be set at 100 MHz with a tuning range of 1.25 MHz through a fiber delay line.By employing phase-locked and temperature control loops,the repetition rate offset of the two lasers was stabilized with 7.13×10^(−11)fractional instability at an average time of 1 s.Its capabilities in the terahertz regime were demonstrated by terahertz time-domain spectroscopy,achieving a spectral bandwidth of 3 THz with a dynamic range of 30 dB.The large range of repetition rate adjustment in our ASOPS system has the potential to be a powerful tool in the terahertz regime. | Zilin Zhao Daping Luo Yang Liu Zejiang Deng Lian Zhou Gehui Xie Chenglin Gu Yanzhao Yang BinWu Wenxue Li | 2023 | High Power Laser Science and Engineering2023，11，2： | 0 |
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