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| 1 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 2 | Effect of hematocrit on blood pressure via hyperviscosity显示文摘 | Cinar Y Demir G Cinar A B | | 0，，07： | 1 |
| 3 | Impact of gradual blood flow increase on ischemia-reperfusion injury in the rat cremaster microcirculationmodel 显示文摘 | Ozmen S Ayhan S Demir Y | 2008 | J Plast Reconstr Aesthet Surg2008，61，8： | 1 |
| 4 | Accelerated ageing test of aubergine,cucumber and melon seeds in relation to time and temperature variables 显示文摘 | Demir I Ozden Y S Yilmaz K | 2004 | Seed Science and Technology2004，32，： | 1 |
| 5 | The effect of standard posterolateralversus muscle-sparing thoracotomy on multiple parameters显示文摘 | Akcali Y Demir H Tezcan B | 2003 | AnnThorac Surg2003，76，： | 1 |
| 6 | Effect of hematocrit on blood pressure via hyperviscosity显示文摘 | ??nar Y Demir G Pac M | 1999 | American journal of hypertension1999，12，7： | 1 |
| 7 | Effect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats显示文摘 | Cetinkaya Demir B Uyar Y Ozbilgin K | 2013 | J Obstet Gynaecol Res2013，39，1： | 1 |
| 8 | Impact of gradual blood flow increase on ischemia-reperfusion injury in the rat cremaster microcirculationmodel显示文摘 | Ozmen S Ayhan S Demir Y | 2008 | J Plast Reconstr Aesthet Surg2008，61，8： | 1 |
| 9 | Antigen location contributes to the pathological features of a transplanted heart graft显示文摘 | Chen Y Demir Y Valujskikh A | 2004 | Am J Pathol2004，164，4： | 1 |
| 10 | Effect of NaCl and proline on bean seedlings cultured in vitro 显示文摘 | Demir Y Kocacaliskan I | 2002 | Biologia Plantarum2002，45，4： | 1 |
| 11 | The psychosocial work environment and burnout among the Swedish reg- istered and assistant nurses: The main, mediating and moderating role of empowerment显示文摘 | Hochwailder J Cavus M F Demir Y | 2007 | Nurs Health Sci2007，9，3： | 1 |
| 12 | Impact of gradual blood flow in- crease on ischemia-reperfusion injury in the rat cremaster microcir- eulationmodel显示文摘 | Ozmen S Ayhan S Demir Y | 2008 | J Plast Reconstr Aesthet Surg2008，61，8： | 1 |
| 13 | Impact of gradual blood flow increase on ischemia-reperfusion injury in the rat cremaster microcirculationmodel显示文摘 | Ozmen S Ayhan S Demir Y | 2008 | J Plast Reconstr Aesthet Surg2008，61，8： | 1 |
| 14 | Pedtoxifylline and N-acelycysteine in hepa-tic ischemia/ reperfusion injury显示文摘 | Demir Y Inal-Erden M | 1998 | Clin Chim Acta1998，275，2： | 1 |
| 15 | The effect of standard posterolateral versus muscle-sparing thoracotomy on multiple parameters显示文摘 | AKCALI Y DEMIR H TEZCAN B | 2003 | Ann Thorac Surg2003，76，4： | 1 |
| 16 | Clinicopathological characteristics of thyroid cancer in patients on dialysis for end- stage renal disease显示文摘 | Demirer AN Kemal Y Gursoy A | 2008 | Thyroid2008，18，1： | 1 |
| 17 | The effect of standard postolateral versus muscle- sparing thoracotomy on multiple parameters 显示文摘 | Akcli Y Demir H Tezcan B | 2003 | Ann Thorac Surg2003，76，4： | 1 |
| 18 | Arsenic related hearing loss in miners显示文摘 | Gülin G?k?en Kesici ?lhan ünlü Arzu Ba?türk Top?u Ceylan Demir Bal Engin Tutkun ?mer H?n? Y?lmaz | 2016 | American Journal of Otolaryngology--Head and Neck2016，，1： | 1 |
| 19 | Accelerated ageing test of aubergine, cucumber and melon seeds in relation to time and temperature variables 显示文摘 | Demir I Ozden Y S Yilmaz K | 2004 | Seed Science and Technology2004，，32： | 1 |
| 20 | Changes in seed lot contant (Ki) and storage longevity (σ, P30 ) in tomato seeds during development in relation to extraction methods 显示文摘 | Demir I Ozcoban M Samit Y 2001 | 2001 | Plant Varit Seeds2001，14，： | 1 |
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