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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | The significance of oil spill dispersants 显示文摘 | LESSARD R R DEMARCO G | 2000 | Spill Science & Technology Bulletin2000，6，1： | 1 |
| 3 | Insulin resistance, oxidative stress, and podocyte inju- ry:role of rosuvastatin modulation of filtration barrier inju- ry显示文摘 | WHALEY-CONNELL A DEMARCO V G LASTRA G | 2008 | Am J Nephrol2008，28，1： | 1 |
| 4 | A new transgene reporter for in vivo magnetic resonance imaging 显示文摘 | Genove G DeMarco U Xu H | 2005 | Nat Med2005，11，4： | 1 |
| 5 | Insulin resistance,oxidative stress,and podocyte injury:role of rosuvastatin modulation of filtration barrier injury显示文摘 | Whaley CA DeMarco VG Lastra G | 2008 | Am J Nephrol2008，28，1： | 1 |
| 6 | The role of tissue renin- angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness显示文摘 | Aroor AR Demarco VG Jia G | 2013 | Front Endocrinol (Lausanne)2013，29，4： | 1 |
| 7 | The significance of oil spill dis- persants 显示文摘 | Lessard R R Demarco G | 2000 | Spill science & Technology Bulletin2000，6，1： | 1 |
| 8 | Adaptive mechanisms to compensate for overnutrition-induced cardiovascular abnormalities 显示文摘 | PULAKAT L DEMARCO V G ARDHANARI S | 2011 | Am J Physiol Regul Integr Comp Physiol2011，301，4： | 1 |
| 9 | The significance of oil spill dispersants 显示文摘 | Lessard R R Demarco G | 2000 | Spill Science & Technology Bulletin2000，6，1： | 1 |
| 10 | Storing biological se- quence databases in relational form显示文摘 | Xie G DeMarco R Blevins R | 2000 | Bioinformatics2000，16，3： | 1 |
| 11 | Oxidative stress contributes to pulmonary hypertension in the transgenic (mren2) 27 rat 显示文摘 | DeMarco V G Habibi J Whaley-Connell A T | 2008 | Am J Physiol Heart Circ Physiol2008，294，6： | 1 |
| 12 | Glutamine and barrier function in cultured Caco-2 epithelial cell monolayers 显示文摘 | DeMarco V G Li N Thomas J | 2003 | J Nu- tr2003，133，： | 1 |
| 13 | Cause-specificmortality in type 2 diabetes: the Verona diabetes study显示文摘 | DeMarco R Locatelli F Zoppini G | 1999 | Diabetes Care1999，22，： | 1 |
| 14 | The role of tissue reninangiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness显示文摘 | Aroor AR Demarco VG Jia G | 2013 | Front Endocrinol (Lausanne)2013，4，： | 1 |
| 15 | A cl-assroom mind/body wellness intervention for older adults with chronic illness:compating immediate and 1-year benefits显示文摘 | Rybarczyk B DeMarco G DeLaCruz M | 2001 | Behav Med2001，27，1： | 1 |
| 16 | A new transgene reporter for in vivo magnetic resonance imaging显示文摘 | Genove G DeMarco U Xu H Goins W F Ahrens E T | 2005 | Nat Med2005，11，： | 1 |
| 17 | The significance of oil spill dispersants 显示文摘 | Lessar R Demarco G | 2000 | Spill Science & Technology Bulletin2000，6，1： | 1 |
| 18 | A monte carlo-based method to estimate radiation dose from spiral CT from phantom testing to patient-specific models显示文摘 | Jarry G DeMarco JJ Beifuss U | 2003 | Phys Med Biol2003，48，： | 1 |
| 19 | The role of tissue renin-angio-aldosterone system in the development of endothelial dysfunction andarterial stiffness显示文摘 | Aroor AR Demarco VG Gia G | 2013 | Frome Endocrinol( Lausanne)2013，，4： | 1 |
| 20 | The role of tissue renin - angio- tensin - aldosterone system in the development of endothelial dysfunc- tion and arterial stiffness显示文摘 | Aroor AR Demarco VG Jia G | 2013 | Front Endoerinol: Lausanne2013，4，： | 1 |
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