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134篇 您的检索式:作者名="Delforge"
    题名 作者 年代 出处 被引量
1Neutrophil extracellular trap cell death requires both autophagy and superoxide generation显示文摘嗜中性的细胞外的陷井(网) 是能套住并且降级的细胞外的染色质结构微生物。他们从激活称为网络房间死亡,或 NETosis 的一个房间死亡程序的 neutrophils 产生。NETosis 的激活被显示了包含 NADPH oxidase 活动,原子信封的崩溃和大多数小粒膜,网的原子染色质和形成的 decondensation。我们报导在 phorbol,十四酸盐醋酸盐(PMA ) 刺激了 neutrophils,细胞内部的染色质 decondensation 和网形成跟随 autophagy 和 superoxide 生产,哪个被要求调停导致 PMA 的 NETosis 并且独立于对方发生。从有长期的 granulomatous 疾病的病人的 Neutrophils,缺乏 NADPH oxidase 活动,仍然展出导致 PMA 的 autophagy。相反地,导致 PMA 的 NADPH oxidase 活动没被 autophagy 的药理学抑制影响。有趣地,任何一个 autophagy 的抑制或 NADPH oxidase 阻止细胞内部的染色质 decondensation,它为 NETosis 和网形成是必要的,并且导致 apoptosis 的特点描绘的房间死亡。当 autophagy 或 NADPH oxidase 活动被阻止时,这些结果显示 apoptosis 可能为 NETosis 作为一个备份节目工作。Quinten Remij sen Tom Vanden Berghe Ellen Wirawan Bob Asselbergh Eef Parthoens Riet De Rycke Sam Noppen Michel Delforge Jean Wlllems Peter Vandenabeele 2011Cell Research2011,21,2:46
2多发性骨髓瘤治疗策略进展显示文摘多发性骨髓瘤仍是一种不可治愈的血液肿瘤,近10年的治疗突破很大程度上依赖新药的研发,主要包括蛋白酶体抑制剂硼替佐米、免疫调节剂如来那度胺和沙利度胺等。力求达到完全缓解(CR)是目前的治疗目标,因为CR意味着无进展生存期(PFS)甚至总生存期(OS)的延长。以新药为基础的不同诱导方案显著提高一线治疗缓解率。缓解后或移植后进行巩固和维持治疗显著延长PFS。文章主要对包含新药的诱导方案进行总结,并简要讨论难治复发骨髓瘤患者的治疗。Michel Delforge(口述) 庄俊玲(编译) 2012中国实用内科杂志2012,32,3:7
3Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells显示文摘Lagneaux L Delforge D Bron D 1998Blood1998,91,7:2
4Human marrow mes- enchymal stem cell culture:serum-free medium allows better ex- pansion than classical alpha-MEM medium显示文摘Meuleman N Tondreau T Delforge A 2006Eur J Haematol2006,76,4:1
5Endoscopic ultrasonography in the diagnosis and staging of pancreatic and ampullary cancer: influence on patient management 显示文摘Gillard V Delforge M Demoulin JC 2000Rev Med Liege2000,55,2:1
6Ultrasonic low-energy treatment:a novel approach to induce apoptosis in human leukemic cells显示文摘Lagneaux L de Meulenaer EC Delforge A 2002Exp Hematol2002,30,11:1
7Continuous lenalido- mide treatment for newly diagnosed multiple myeloma 显示文摘Palumbo A Hajek R Delforge M 2012N Engl J Med2012,366,19:1
8Ultrasonic low-energy treatment:a novel approach to induce apoptosis in human leukemic cells显示文摘Lagneaux L de Meulenaer E C Delforge A 0,,11:1
9Ex vivo myeloid differentiation of cord blood CD34^+ eells zcomparison of four serum-free media containing bovine or human albumin显示文摘De Bruyn C Delforge A Bron D 2003Cytotherapy2003,5,2:1
10Management of treat- ment - emergent peripheral neuropathy in multiple myeloma 显示文摘Richardson PG Delforge M Beksac M 2012Leukemia2012,26,:1
11Comparison of the coexpression of CD38,CD33 and HLA-DR antigens on CD34+ purified cells from human cord blood and bone marrow显示文摘De Bruyn C Delforge A Bron D 1995Stem Cells1995,13,3:1
12Ultrasonic lowenergy treatment:a novel approach to induce apoptosis in human leukemic cells显示文摘Lagneaux L DeMeulenaer E C Delforge A 2002Exp nematol2002,30,11:1
13Treatment - related peripheral neuropathy in multiple myeloma: the challenge continues显示文摘Delforge M Blade J Dimopoulos MA 2010Lancet Oncol2010,11,11:1
14Mesenchymal stem cells derived from CD133 positive ceils in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity显示文摘Tondreau T Meuleman N Delforge A 2005Stem Cells2005,23,8:1
15Ultrasonic low energy tre, atment: a novel approach to induce apoptosis in human leukemic cells 显示文摘LAGNEAUX L de MEULENAER E C DELFORGE A 2002Exp Hematol2002,30,11:1
16Donor lymphocyte infusions in adult haploidentical transplant: a dose finding study 显示文摘Lewalle P triffet A Delforge A 2003Bone Marrow Transplantation2003,31,:1
17Mesenchymal stem ceils derived from CD133-positive cells in mobilized peripheral blood and cord blood: proliferation, Oct4 expression, and plasticity 显示文摘Tondreau T Meuleman N Delforge A 2005Stem Cells2005,23,8:1
18Mesenchymal stem cells derived from CD133 positive cells in mobilized peripheral blood and cord blood:proliferation,Oct4 expression,and plasticity显示文摘TONDREAU T MEULEMAN N DELFORGE A 2005Stem Cells2005,23,8:1
19Management of treat- ment emergent peripheral neuropathy in multiple myeloma 显示文摘Richardson PG Delforge M Beksac M 2012Leukemia2012,26,4:1
20Threatening clots in MGUS and myeloma显示文摘Ludwig H Delforge M 2010Blood2010,115,24:1
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