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| 1 | Seawater hydraulics:From the sea surface to depths of 11000 meters显示文摘Using seawater as the working medium,the seawater hydraulic system has significant advantages in the deep sea,such as eliminating contamination caused by oil leaks,no oil tanks,and the ability to automatically adapt to sea depths.As working depths increase,seawater hydraulic technology faces enormous challenges.First,the physical and chemical properties of seawater,such as density,temperature,and composition,change significantly.Second,hydraulic components are subject to an environmental pressure of up to 110 MPa,which causes serious deformation or even seizure of moving pairs and significantly affects the efficiency of hydraulic components.The friction and wear characteristics between the moving pairs also significantly change with the change in sea depth,therefore developing the matching material according to depth is necessary.Finally,the cavitation characteristic of a valve port is obviously different from that on land,so special material and structure should be used to improve the service life of the valve port.These factors severely restrict the improvement of the working depths and characteristics of seawater hydraulic components.This article focuses on the abovementioned problems and provides solutions for deep-sea seawater hydraulic technology. | LIU YinShui CHENG Qian WANG ZhenYao PANG Hao DENG YiPan ZHOU XinPing LUO XiaoHui CUI Yan WU DeFa | 2022 | Science China(Technological Sciences)2022，65，9： | 2 |
| 2 | PORK PRODUCTION SYSTEMS IN CHINA:A REVIEW OF THEIR DEVELOPMENT,CHALLENGES AND PROSPECTS IN GREEN PRODUCTION显示文摘This paper reviews the changes in pork production in China,the largest pork producing and consuming nation in the world.The pork sector in China has changed dramatically since the 1990s,with large-scale intensive pork production systems replacing the former,exclusively family-based pork production systems.Modern breeding,feeding,vaccinating,and management technologies are widely used now.However,smallholders still account for a large proportion of the total production.The intensification and specialization of the pork sector is expected to continue in the future,but there is increasing awareness and pressure to develop more environmentally-sustainable production systems.The relative shortage of domestically produced feed,the low utilization efficiency of feed ingredients,the large emissions of nitrogen and phosphorus to the environment,the high use of antibiotics,and the presence of residual metals in manures are very large challenges for the pork sector nowadays.To solve these problems,techniques including new feed resource utilization,precise feeding,low-protein diets,alternatives to antibiotics and increased manure recycling are all important topics and research directions today.With new techniques and management approaches,it is possible to build more sustainable pork production systems in China. | Shuai ZHANG Xin WU Dandan HAN Yong HOU Jianzhuang TAN Sung Woo KIM Defa LI Yulong YIN Junjun WANG | 2021 | Frontiers of Agricultural Science and Engineering2021，8，1： | 2 |
| 3 | Dietary supplementation with zinc oxide decreases expression of the stem cell factor in the small intestine of weanling pigs显示文摘 | Deyuan Ou Defa Li Yunhe Cao Xilong Li Jingdong Yin Shiyan Qiao Guoyao Wu | 2007 | The Journal of Nutritional Biochemistry2007，，12： | 1 |
| 4 | Friction and wear characteristics of WC–10Co–4Cr/Si 3 N 4 tribopair lubricated under silt-laden water显示文摘 | Defa Wu Yinshui Liu Shudong Yang Zheng Yang Hui Tang | 2012 | Wear2012，，： | 1 |
| 5 | Study on the control methods of a water hydraulic variable ballast system for submersible vehicles显示文摘 | Liu Yinshui Zh-ao Xufeng Wu Defa | 2015 | Ocean Engineering2015，108，： | 1 |
| 6 | Research on the port valve of a water hydraulic axial pump显示文摘 | Liu Yinshui Wu Defa Long Lei | 2009 | Journal of Process Mechanical Engineering2009，223，3： | 1 |
| 7 | Small molecules targeting protein-protein interactions for cancer therapy显示文摘Protein-protein interactions(PPIs)are fundamental to many biological processes that play an important role in the occurrence and development of a variety of diseases.Targeting the interaction between tumour-related proteins with emerging small molecule drugs has become an attractive approach for treatment of human diseases,especially tumours.Encouragingly,selective PPI-based therapeutic agents have been rapidly advancing over the past decade,providing promising perspectives for novel therapies for patients with cancer.In this review we comprehensively clarify the discovery and development of small molecule modulators of PPIs from multiple aspects,focusing on PPIs in disease,drug design and discovery strategies,structure-activity relationships,inherent dilemmas,and future directions. | Defa Wu Yang Li Lang Zheng Huan Xiao Liang Ouyang Guan Wang Qiu Sun | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 1 |
| 8 | Advantages of switching to elvitegravir/cobicistat/emtricitabine/ tenofovir therapy in virologically-suppressed people living with human immunodeficiency virus/acquired immune deficiency syndrome显示文摘To the Editor:With recent advances in antiretroviral therapy(ART)regimens,many patients may benefit from switching drugs.The new combination drug,elvitegravir/cobicistat/emtricitabine/tenofovir(E/C/F/TAF),has been approved for use in people living with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AID[PLWHA])in China and has also been included within the scope of medical insurance.This single-tablet regimen provides a convenient,once-daily,treatment option for many PLWHA.E/C/F/TAF was shown to increase adherence to ART and decrease the risk of drug resistance and virological failure.[1–4]However,another study showed a higher level of several lipid parameters in patients with tenofovir alafenamide(TAF)-based therapy compared with tenofovir(TDF)-based therapy in treatment-naïve and-experienced adults.[5]In 2019,a phase IV clinical study of E/C/F/TAF was conducted at our Antiviral Treatment Center,allowing us to explore the virological and immunological responses during 12 months of follow-up after switching.We also explored the changes in renal function,liver function,and lipid parameters in PLWHA. | Lina Fan Lei Li Liying Gao Yue Hu Aiping Yu Defa Zhang Chunting Qiu Rong Huang Yue Wu Ping Ma | 2022 | Chinese Medical Journal2022，135，22： | 0 |
| 9 | Knowledge mapping analysis of the track and hotspot of water lubrication:A scientometrics review显示文摘With the enhancement of environmental protection awareness of the international community and the continuous promotion of green and sustainable development of manufacturing industry,water lubrication instead of mineral oil has become the future development trend due to its green,pollution-free,clean,safe,and sustainable advantages especially in ships,marine,coal mining,and other fields.In recent years,with the rapid development of water lubrication research,significant progress has been made in related research knowledge domain and discipline.A systematic and extensive assessment of water lubrication research has become increasingly important.The objective of this research is to reveal the research status,research hotspots,and development trends in the field of water lubrication.Therefore,CiteSpace was used to conduct a systematic bibliometric and scientometrical analysis of 1,792 publications from Web of Science core collection database(1997–2021).The results show that China and USA are the most productive countries in the field of water lubrication and have made outstanding contributions.Through the analysis of hot key words and co-citation references,this paper reviews the research status of water lubrication in three aspects:(1)lubricating medium modification;(2)material preparation;(3)surface optimization.It has become a research hotspot to promote the superlubricity contact interface and the application of nanotechnology.The results of this study can make a significant contribution to the development of water lubrication by providing a comprehensive understanding of the research status and research hotspots in this field.Personal understanding and discussion of research hotspots and research status are expected to provide insights into future research trends.In addition,this study will provide valuable references and guidelines for researchers who are interested in this field. | Runzhou XU Defa WU Zhenyao WANG Yipan DENG Qian CHENG Hao PANG Wenshu WEI Yinshui LIU | 2023 | Friction2023，11，9： | 0 |
| 10 | Nonlinear sealing force of a seawater balance valve used in an 11000-meter manned submersible显示文摘Balance valve is a core component of the 11000-meter manned submersible“struggle,”and its sealing performance is crucial and challenging when the maximum pressure difference is 118 MPa.The increasing sealing force improves the sealing performance and increases the system’s energy consumption at the same time.A hybrid analytical–numerical–experimental(ANE)model is proposed to obtain the minimum sealing force,ensuring no leakage at the valve port and reducing energy consumption as much as possible.The effects of roundness error,environmental pressure,and materials on the minimum sealing force are considered in the ANE model.The basic form of minimum sealing force equations is established,and the remaining unknown coefficients of the equations are obtained by the finite element method(FEM).The accuracy of the equation is evaluated by comparing the independent FEM data to the equation data.Results of the comparison show good agreement,and the difference between the independent FEM data and equation data is within 3%when the environmental pressure is 0–118 MPa.Finally,the minimum sealing force equation is applied in a balance valve to be experimented using a deep-sea simulation device.The balance valve designed through the minimum sealing force equation is leak-free in the experiment.Thus,the minimum sealing force equation is suitable for the ultrahigh pressure balance valve and has guiding significance for evaluating the sealing performance of ultrahigh pressure balance valves. | Zhenyao WANG Yinshui LIU Qian CHENG Runzhou XU Yunxiang MA Defa WU | 2023 | Frontiers of Mechanical Engineering2023，18，1： | 0 |
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