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| 1 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 2 | Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica显示文摘Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase(LOX) inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities respectively.Methanolic extract(MEMI),successive water extract (SWMI) and ethyl acetate fraction(EMEMI),n-butanol fraction(BMEMI) and water soluble fraction (WMEMI) of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions. | Mohan CG Deepak M Viswanatha GL Savinay G Hanumantharaju V Rajendra CE Praveen D Halemani | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，4： | 2 |
| 3 | Pdcatalyzed efficient cross couplings of 3-iodochromones with triaryl bismuths as substoichiometric multicoupling organometallic nucleophiles显示文摘 | Rao Maddali L N Venkatesh V Jadhav Deepak N | 2009 | Synlett2009，16，： | 1 |
| 4 | 显示文摘 | Ramanathan S Karthikeyan R Deepak K V | 2006 | Journal of Materials Science & Technology2006，22，5： | 1 |
| 5 | Optimization of media composition for nattokinase production by Bacillus subtilis using response surface methodology 显示文摘 | Deepak V Kalishwaralal K Ramkumarpandi - an S | 2008 | Biore - source Technology2008，99，17： | 1 |
| 6 | A compact UWB MIMO antenna with reflector to enhance isolation显示文摘 | ROSHNA T K DEEPAK U SAJITHA V R | 2015 | IEEE Trans Antenna Propagation2015，63，4： | 1 |
| 7 | Optimization of media composition for Nattokinase production by Bacilltus subtilis using response surface methodology显示文摘 | Deepak V Kalishwaralal K Ramkumarpandian S | | 0，，17： | 1 |
| 8 | Optimization of media composition for Nattokinase production by Bacillus subtilis using response surface methodology显示文摘 | Deepak V Kalishwaralal K Ramkumarpandian S | 2008 | Bioresource Technology2008，99，： | 1 |
| 9 | Coplanar stripline-fed compact UWB antenna显示文摘 | ROSHNA T K DEEPAK U SAJITHA V R | 2014 | IEEE Electron Lett2014，50，17： | 1 |
| 10 | A free-space bistatic calibration technique for the measurement of parallel and perpendicular reflection coefficients of planar samples显示文摘 | Ghodgaonkar Deepak K Varadan Vasundara V | 1991 | IEEE Trans IM1991，40，1： | 1 |
| 11 | Optimization of media composition for Natokinase production by Bacillus subtilis using response surface methodology 显示文摘 | Deepak V Kalishwaralal K Ramkumarpandian S | 2008 | Bioresour Technol2008，99，17： | 1 |
| 12 | Hot deformation behavior of 2124 A1 alloy显示文摘 | RAMANATHAN S KARTHIKEYAN R DEEPAK V | 2006 | Journal of material science and technology2006，22，61： | 1 |
| 13 | Evaluation ofprotective efficacy of CC-2 formulation against topical lethal dose ofT-2 toxin in mice显示文摘 | MONA A DEEPAK P LAKSHMANA-RAO P V | 2012 | Food and Chemical Toxicology2012，50，3： | 1 |
| 14 | A review of thesubstrates used in microbial fuel cells(MFCs)for sustainableenergy production显示文摘 | DEEPAK P GILBERT V B LUDO D | 2010 | Bioresource Technology2010，101，6： | 1 |
| 15 | Optimization of media composition for nattokinase production by Bacillus subtilis using response surface methodology显示文摘 | DEEPAK V KALISHWARALAL K RAMKUMARPANDIAN S | 2008 | Bioresource Technology2008，99，17： | 1 |
| 16 | Hydrotropic Extraction of Curcuminoids from Turmeric Separation Science and Technology显示文摘 | Deepak V Dandekar V G Gaikar | 2003 | 38(5): 1185-12152003，38，5： | 1 |
| 17 | Optimization of media composition for Nattokinase production by Bacillus subtilis using response surface methodology显示文摘 | Deepak V Kalishwaralal K Ramkumarpandian S | 2008 | Bioresour Technol2008，99，17： | 1 |
| 18 | Surfactant-free CdTe nanoparticles mixed MEH-PPV hybrid solar cell deposited by spin coating technique显示文摘 | Deepak V Ranga R | 2009 | Solar Energy Mate Solar Cells2009，93，9： | 1 |
| 19 | Polymerase chain reaction (PCR) for detection of Brucella melitensis in goat milk显示文摘 | Gupta V K Deepak K Verma Rout P K | 2006 | Small Ruminant Research2006，65，： | 1 |
| 20 | Polymerase chain reaction (PCR) for detection of Brucella melitensis in goat milk显示文摘 | Gupta V K Deepak K V Rout P K | 2006 | Small Ruminant Research2006，65，： | 1 |
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