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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | The spectrum of neuromyelitis optica显示文摘 | Dean M Wingerchuk Vanda A Lennon Claudia F Lucchinetti Sean J Pittock Brian G Weinshenker | 2007 | Lancet Neurology2007，，9： | 3 |
| 3 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 4 | Dev Cell:科学家阐明人类胚胎原生殖细胞发育的分子机制显示文摘近日,刊登于国际杂志Developmental Cell上的一项研究报道中,来自巴布拉汉研究所(Babraham Insdtute)的研究人员通过研究调查了原生殖细胞发育的早期阶段,同时他们在实验室开发了一种产生类似细胞的策略,这种酷似人类原始生殖细胞的产生对于未来生殖领域的研究,以及分析人类潜在的继代基因调控的遗传机制非常重要。 | Ferdinand von Meyenn Rebecca V. Berrens Simon Andrews Fátima Santos Amanda J. Collier Felix Krueger Rodrigo Osorno Wendy Dean Peter J. Rugg-Gunn Wolf Reik | 2016 | 现代生物医学进展2016，16，35： | 2 |
| 5 | Current and future concepts in stroke prevention显示文摘 | O' Rourke F Dean N Akhtar N | 2004 | CMAJ2004，170，： | 1 |
| 6 | Motor assessment scale scores as a measure of rehabilitation outcome following stroke 显示文摘 | Dean C Mackey F | 1992 | Australian Journal of Physiotherapy1992，38，： | 1 |
| 7 | Bigtable : A Distributed Storage System for Structured Data 显示文摘 | Chang F Dean J Ghemawat S | 2008 | ACM Transactions on Computer Systems (TOCS)2008，26，2： | 1 |
| 8 | Boron nitride substrates for high-quality graphene electronics显示文摘 | Dean C R Young A F Meric I | 2010 | Nat Nnotechn2010，5，10： | 1 |
| 9 | BigTable: a distributed storage system for structured data显示文摘 | CHANG F DEAN J GHEMAWAT S | 2008 | ACM Transactions on Computer Systems2008，26，2： | 1 |
| 10 | In- fluence of hydrology on rainfall-runoff metal element speciation 显示文摘 | DEAN C M SANSALONE J J CARTLEDGE F K | 2005 | Journal of Environmental Engineering2005，131，4： | 1 |
| 11 | Stress analysis of drillstring threaded connections using the finite element method显示文摘 | MACDONALD K A DEANS W F | 1995 | Engineering Failure Analysis1995，2，1： | 1 |
| 12 | The use of the splitHopkinson pressure bar techniques in high strain rate mate-rials testing显示文摘 | Al-Mousawi M M Reid S R Deans W F | 1997 | Proceedings of the Institution of MechanicalEngineers Part C:Journal of Mechanical Engineering Sci-ence1997，211，4： | 1 |
| 13 | Spatial patterns and competition of tree species in a Douglas-fir chronosequence on Vancouver Island显示文摘 | Getzin S Dean C He F | | 0，，： | 1 |
| 14 | Long non-coding RNAs and chro- matin regulation 显示文摘 | De Lucia F Dean C | 2011 | Curr Opin Plant Biol2011，14，2： | 1 |
| 15 | Conservation of methyl ation reprogramming in mammaIian development :aberrant re programming in cloned embryos 显示文摘 | Dean W Santos F Stojkovic M | 2001 | Proc Natl Acad Sc USA2001，98，13： | 1 |
| 16 | Intraabdom inal hyperten- sion is anindependent cause of postoperative renalimpairment 显示文摘 | Sugrue M Jones F Deane SA | 1999 | Arch Surg1999，134，： | 1 |
| 17 | The ethylene biosynthesis inducing xylanase: its induction in Trichoderma viride and certain plant pathogens显示文摘 | DEAN J F D GAMBLE H R ANDERSON J D | 1989 | Phytopathology1989，，79： | 1 |
| 18 | Laccase and the deposition of lignin in vascular plants 显示文摘 | Dean J F D Eriksson K-E L | 1994 | Holzforschung1994，48，： | 1 |
| 19 | Removing heavy metals from waste water 显示文摘 | Dean J G Bosqui F L Bermond A | 1972 | Environ Sci Technol1972，6，6： | 1 |
| 20 | Conservation of methylation reprogramming in mammalian development:aberrant reprogramming in cloned embryos显示文摘 | Dean W Santos F Stojkovic M Zakhartchenko V Walter J Wolf E Reik W | 2001 | Proceedings of the National Academy of Sciences2001，98，13： | 1 |
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