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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 显示文摘 | de Oliveira M F May J E | 2000 | J Non-Cryst Solids2000，，273： | 1 |
| 3 | Designing reusable rule-based architectures with design patterns显示文摘 | de Souza M A F Ferreira M A G V | 2002 | Expert Systems with Applications2002，23，39： | 1 |
| 4 | Selective linear dimerization of 1,3-butadiene by palladium compounds immobilized into 1-nbutyl-3-methyl imidazolium ionic liquids显示文摘 | Suarez P A Z de Souza R F | 1998 | Polym Bull1998，40，： | 1 |
| 5 | Input and output quantized feedback linear systems显示文摘 | Coutinho D F Fu M Y De Souza C E | | 0，，03： | 1 |
| 6 | Depositional and diagenetic controls on the reservoir quality of Lower Creta- ceous Pendeneia sandstones, Potiguar rift basin, Brazil显示文摘 | dos Anjos S M C de Ros L F de Souza R S | 2000 | AAPG Bulletin2000，84，11： | 1 |
| 7 | Impact of genetically modified Enterobacter cloacae on indigenous endophytic community of Citrus sinensis seedlings显示文摘 | Andreote F D Gullo M J M de Souza Lima A O | 2004 | Journal of Microbiology2004，42，3： | 1 |
| 8 | Biphasic ethylene polymerization with a diimine nickel catalyst显示文摘 | Mauler R S de Souza R F | 2001 | Macromol Rapid Commun2001，22，6： | 1 |
| 9 | Depositional and diagenetic control on the reservoir quality of lower cretaceous pendencia sandstones, Potiguar rift basin, Brazil显示文摘 | ANJOS S M C DE ROS L F DE SOUZA R S | 2000 | AAPG Bull2000，84，11： | 1 |
| 10 | Gray mat- ter volumes in obsessive-compulsive disorder before and after fluoxetine or cognitive-behavior therapy: a randomized clinicaltrial显示文摘 | Hoexter M Q de Souza Duran F L D'AIcante C C | 2012 | Neuropsychopharmacology2012，37，3： | 1 |
| 11 | Characterization of Pd-CeO2 interaction on alumina support and hydrogenation of 1,3-butadiene 显示文摘 | Schmal M De Souza Monteiro R Noronha F B Dieguez L C | 1995 | Appl Catal A1995，131，： | 1 |
| 12 | Low plasma levels of L- arginine, impaired intraplatelet nitric oxide and platelet hyperaggregability: implications for cardiovascular disease in depressive patients 显示文摘 | Pinto V L de Souza P F Brunini T M | 2012 | J Affect Disord2012，140，2： | 1 |
| 13 | Nucleation and growth of mullite whiskers from lanthanum-doped aluminosilicate melts显示文摘 | Regiani I Magalh(a)es W L E De Souza D P F Paiva-Santos CO De Souza M F | | 0，，01： | 1 |
| 14 | Influence of 17a, 20fl-dihydroxy-4-pregnen-3-one injected into a post-ovulatory female on the reproductive behavior of male Nile tilapia (Oreochromis niloticus)显示文摘 | de Souza S M G Lucion A B Wassermann G F | 1998 | Comp Biochem Physiol A-Mol Integr Physiol1998，119，3： | 1 |
| 15 | Evalu- ation of sample preparation protocols for proteomic analysis of sunflower leaves显示文摘 | Silva M A O da Gargia J S Souza G H M F de | 2010 | Talanta2010，，80： | 1 |
| 16 | Fluorescence spectroscopy of coastal and marine waters显示文摘 | De Souza Sierra M M Donard O F X Lamotte M | 1994 | Mar Chem1994，47，： | 1 |
| 17 | Morpho- logic analysis of porous polyamide 6, 6 membranes prepared by phase inversion 显示文摘 | ZENIA M RIVEROS R de SOUZA J F | 2008 | Desalination2008，221，： | 1 |
| 18 | Depositional and diagenetic control on the reservoir quality of Lower Cretaceous Pendencia sandstones, Potiguar rift basin, Brazil显示文摘 | Anjos S M C De Ros L F De Souza R S | 2000 | AAPG Bulletin2000，84，11： | 1 |
| 19 | GTO controlled series capacitors: multi-module and multi-pulse arrangements显示文摘 | De Souza L F W Watanabe E H Aredes M | 2000 | IEEE Trans on Power Delivery2000，15，2： | 1 |
| 20 | Ionic liquid-phase asymmetric catalytic bydrogenation:hydrogen concentration effects on enantioselectivity显示文摘 | BERGER A DE SOUZA R F DELGADO M R | 2001 | Tetrahedron:Asymmetry2001，12，： | 1 |
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