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| 1 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 2 | The BRI and RCEP: ensuring cooperation in the liberalisation of trade in Asia显示文摘The Belt and Road Initiative(BRI)offers the prospect of trade integration between Asia and Europe.But it is subject to a number of risks,some of them are similar to those associated with the Trans-Pacific Partnership(TPP).East Asian trade liberalisation in the 1990s involved collaborative autonomy–a cooperative process of outward-looking unilateral liberalisation on a‘most favoured nation’(MFN)basis–rather than the creation of a regional free trade area.By contrast,the TPP has sought to create a free trade area,which would have led to trade diversion and have had other unsatisfactory features.The combination of BRI with the Regional Cooperation Economic Partnership(RCEP)might offer the possibility of outward-looking liberalisation,one which is neither dominated by China nor subject to the trade diversion of the TPP.This combination would bring strength and legitimacy to the BRI. | David Vines | 2018 | Economic and Political Studies2018，6，3： | 5 |
| 3 | Virtual colonoscopy: Utility, impact and overview显示文摘Computed tomography (CT) colonoscopy is a well-established technique for evaluation of colorectal cancer. Significant advances have been made in the technique of CT colonoscopy since its inception. Excellent results can be achieved in detecting both colorectal cancer and significant sized polyps as long as a meticulous technique is adopted while performing CT colonoscopy. Furthermore, it is important to realize that there is a learning curve involved in interpreting these studies and adequate experience is essential to achieve high sensitivity and specificity with this technique. Indications, contraindications, technique and interpretation, including potential pitfalls in CT colonoscopy imaging, are reviewed in this article. Recent advances and the current role of CT colonoscopy in colorectal cancer screening are also discussed. | Dhakshina Ganeshan Khaled M Elsayes David Vining | 2013 | World Journal of Radiology2013，5，3： | 4 |
| 4 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 5 | Initial results in the develop-ment of a synthetic aperture microwave radiometer显示文摘 | David M Le Vine | | 0，，04： | 1 |
| 6 | discrete scatter Model for Microwave radar and Radiometer Response to Corn: Comparison of Theory and Data显示文摘 | Narinder S Chauhan David M Le Vine Lang R H | 1994 | IEEE Transactions on Geosciences and Remote Sensing1994，32，2： | 1 |
| 7 | Remaking macroeconomic policy after the global financial crisis:a balance-sheet approach显示文摘 | Christopher Adam David Vines | | 0，，04： | 1 |
| 8 | Scattering from Thin Dielectric Disks显示文摘 | David M Le Vine Schneider A Lang R H | 1985 | IEEE Trans Antenna Propagat1985，33，： | 1 |
| 9 | Soil Moisture Mapping at Regional Scales Using Microwave Radiometry: The Southern Great Plains Hydrology Experiment显示文摘 | Jackson T J David M Le Vine | 1999 | IEEE Trans ON Geosci & Remote Sens1999，37，： | 1 |
| 10 | 全球国际收支失衡与新兴市场显示文摘 | Yung Chul Park 樊纲 David Vines | 2006 | 国际经济评论2006，，5： | 1 |
| 11 | Pituitary apoplexy in a child显示文摘 | Sakalas R David RB Vines FS | | 0，，： | 1 |
| 12 | Inefficiency in Public Organizations显示文摘 | Vining Aidan R Weimer David L | 1999 | International Public Management Journal1999，2，1： | 1 |
| 13 | The Influence of Antenna Pattern on Faraday Rotation in Remote Sensing at L-Band 显示文摘 | Le Vine David M Jacob S Daniel Dinnat Emmanuel P | 2007 | IEEE Transactions on Geoscience and Remote Sensing2007，45，9： | 1 |
| 14 | Use of IRI to model the effect of ionosphere emission on earth remote sensing at L- band 显示文摘 | Abraham Saji Le Vine David M | 2004 | Advances in Space Research2004，34，： | 1 |
| 15 | Evaluation of I6-95 to Correct Errors Caused by Faraday Rotation in Passive Microwave Remote Sensing from Space 显示文摘 | Abraham Saji Le Vine David M | 2001 | Adv Space Res2001，27，1： | 1 |
| 16 | Use of Iri to Model the Effect of Ionosphere Emission on Earth Remote Sensing at L-Band 显示文摘 | Abraham Saji Le Vine David M | 2004 | Advances in Space Research2004，34，： | 1 |
| 17 | Extracolonic Findings at Virtual Colonoscopy: An Important Consideration in Asymptomatic Colorectal Cancer Screening显示文摘 | James R. Kimberly MD Kim C. Phillips PhD Pete Santago PhD James Perumpillichira MD Robert Bechtold MD Benoit Pineau MD David Vining MD Richard S. Bloomfeld MD | 2009 | Journal of General Internal Medicine2009，，1： | 1 |
| 18 | The Sensitivity of Synthetic Aperture Radiometers for Remote Sensing Applications from Space 显示文摘 | David M Vine L | 1990 | Radio Science1990，25，4： | 1 |
| 19 | Discrete Scatter Model for Microwave radar and Radiometer Response to Corn: Comparison of Theory and Data显示文摘 | Narinder S Chauhan David M Le Vine Lang R H | 1994 | IEEE Transactions onGeoscience and Remote Sensing1994，32，2： | 1 |
| 20 | ESTAR:A Synthetic Aperture Microwave Radiometer for Remote Sensing Applications显示文摘 | David M Vine L Calvin T | 1994 | Pro of the IEEE1994，82，12： | 1 |
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