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| 1 | Exposure to Mn/ Zn ethylene-bis-dithiocarbamate and glyphosate pesticides leads to neurodegeneration in Caenorhabditis elegans 显示文摘 | Rekek N David AR Nathan SD | 2011 | Neuro Toxicol2011，32，3： | 1 |
| 2 | Role of HLA-B27 in spondyloarthropathies 显示文摘 | Khare SD Luthra HS David CS | 1996 | Curt Top Microbiol Immunol1996，206，： | 1 |
| 3 | Spontaneous inflammatory arthritis in HLA-B27 transgeic mice lacking beta 2-microglobulin : a model of human spondyloarthropathies 显示文摘 | Khare SD Luthra HS David CS | 1995 | J Exp Med1995，182，： | 1 |
| 4 | Revised American Thyroid Association(ATA) management guidelines for patients with thyroid nodules and differentiated thyroid cancer显示文摘 | David SD Gerard MD Bryan RH | 2009 | Thyroid2009，19，： | 1 |
| 5 | Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin,a model of human spondyloarthropathies显示文摘 | Khare SD Luthra HS David CS | 1995 | J Exp Med1995，182，4： | 1 |
| 6 | Interleukin-12 is not essential for silicosis in mice 显示文摘 | Gerald SD Linda MP David RH | 2006 | Particle and Fibre Toxicology2006，27，3： | 1 |
| 7 | Younger and garance genicot, the demand for health care services in rural tanzania显示文摘 | David E Sahn SD | 2003 | Oxford Bulletin of Economice and Statistics2003，65，2： | 1 |
| 8 | Detection of cytokine mRNA production in infiltrating cells in proliferative vitreoretinopathy using reverse transcription polymerase chain reaction显示文摘 | Iaei G Harminder SD Gavin MO David F Patrick JT | 1999 | Br J Ophthalmol1999，83，11： | 1 |
| 9 | Role of HLA - B27 in spondy - loarthropathies 显示文摘 | Khare SD Luthra HS David CS | 1996 | Curr Top Microbiol Immunol1996，35，： | 1 |
| 10 | Surviving severe acute respiratory distress syndrome: Utility of open-lung biopsy and large doses of dexame-thasone显示文摘 | Kedar SD David WA Margarita TC MD | 2005 | The Annals of Thoracic Surgery2005，79，2： | 1 |
| 11 | Viridins bacteriocins of Alphahemolytic streptococci: Isolation, Characterization and Patrial purification Antimicrobiol 显示文摘 | Adnan SD May C Tom David J Law | 1976 | Agents and Chemotherapy1976，9，1： | 1 |
| 12 | Role of HLA-B27 in spondyloarthropathies显示文摘 | Khare SD Luthra HS and David CS | 1996 | Curr Top Microbid Immunol1996，35，2： | 1 |
| 13 | Role of HLA-B27 in spondyloarthropathies显示文摘 | Khare SD Luthra HS and David cs | 1996 | Curr Top Microbiol lmmunol1996，35，2： | 1 |
| 14 | Oral administration of an immunodominant human collagen peptide modulates collagen-induced arthritis显示文摘 | Khare SD Krco CJ Griffiths MM Luthra HS David CS | 1995 | J Immunol1995，155，： | 1 |
| 15 | Malignant peripheral nerve sheath tumors显示文摘 | Barbara SD Bernd WS David GP | 1986 | Cancer1986，57，10： | 1 |
| 16 | Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian显示文摘BACKGROUND Multiple genetic risk factors for Crohn’s disease(CD)have been identified.However,these observations are not consistent across different populations.The protein tyrosine phosphate non-receptor type 2(PTPN2)gene plays a role in various aspects of host defense including epithelial barrier function,autophagy,and innate and adaptive immune response.Two common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)have been associated with risk of CD in Western countries.AIM To evaluate the association of PTPN2 gene polymorphisms with risk of CD in Indian population.METHODS We conducted a prospective case-control study.Patients with CD were recruited,and their clinical and investigation details were noted.Controls were patients without organic gastrointestinal disease or other comorbid illnesses.Two common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)were assessed.DNA was extracted from peripheral blood samples of cases and controls and target DNA was amplified using specific sets of primers.The amplified fragments were digested with restriction enzymes and the presence of polymorphism was detected by restriction fragment length polymorphism.The frequency of alleles was determined.The frequencies of genotypes and alleles were compared between cases and controls to look for significant differences.RESULTS A total of 108 patients with CD(mean age 37.5±12.7 years,females 42.6%)and 100 controls(mean age 39.9±13.5 years,females 37%)were recruited.For the single nucleotide polymorphism(SNP)rs7234029,the overall frequency of G variant genotype(AG or GG)was noted to be significantly lower in the cases compared to controls(35.2%vs 50%,P=0.05).For the SNP rs2542151,the overall frequency of G variant genotype(GT or GG)was noted to be similar in cases compared to controls(43.6%vs 47%,P=0.73).There were no significant differences in minor allele(G)frequency for both polymorphisms between the cases and controls.Both the SNPs had no significant association with age of onset of illness,gender,disease location,disease behaviour,perianal disease,or extraintestinal manifestations of CD.CONCLUSION Unlike observation form the West,polymorphisms in the PTPN2 gene(rs7234029 and rs2542151)are not associated with an increased risk of developing CD in Indian patients. | Kaushik Chatterjee Amit Kumar Dutta Ashish Goel Rekha Aaron Vijayalekshmi Balakrishnan Ajith Thomas Anoop John Rajeeb Jaleel Deepu David Reuben Thomas Kurien SD Chowdhury Ebby George Simon AJ Joseph Prasanna Premkumar Anna B Pulimood | 2022 | World Journal of Gastrointestinal Pathophysiology2022，13，4： | 0 |
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