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| 1 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 2 | Physiological regulation of productivity and water use in Eucalyptus:a review显示文摘 | Christopher LB | 2004 | Forest Ecology and Management2004，193，12： | 1 |
| 3 | Genomics and the biology of parasities显示文摘 | David AJ Mark LB Wim MD | 1999 | Bio Essays1999，21，2： | 1 |
| 4 | Averil M Failure to regulate TNF-induced NF-κB and cell death responses in deficient mice显示文摘 | Eric GL David LB Sophia C | 2000 | Science2000，289，： | 1 |
| 5 | Diagnosis and Management of Syphilis显示文摘 | David LB Jennifer EF | 2003 | Am Fam Physician2003，68，2： | 1 |
| 6 | Endothelin-1 mediates cardiac mast cell degranulation,matrix metalloproteinase activation,and myocardial remodeling in rats显示文摘 | David BM Jason DG Gregory LB | 2004 | J Physiol Heart Circ Physiol2004，287，： | 1 |
| 7 | t3z - Glycoprotein 1 -Dependent anticardiolipin antibodies and risk of ischemic stroke and myocardial infarction: the honolulu heart program 显示文摘 | Robin LB Robert DA David JC | 2001 | Stroke2001，32，8： | 1 |
| 8 | Endocrine consequences of weight loss in obese, hyperandrogenic, anovulatory women 显示文摘 | David SG Sarah LB Rena WP | 1994 | Fertil Steril1994，61，： | 1 |
| 9 | Cerebral Aneurysms 显示文摘 | Jonathan LB Joon KS David WN | 2006 | New England Journal of Medicine2006，355，9： | 1 |
| 10 | Endocrine consequences of weight loss in obese, hyperandrogenic, anovulatory women 显示文摘 | David SG Sarah LB RenaWP | 1994 | Fertil Steril1994，61，： | 1 |
| 11 | Identication of potential fermentation inhibitors in conversion of hybrid poplar hydrolyzate to ethanol显示文摘 | Luo C David LB Harvey W B | 2002 | Biomass and Bioengery2002，22，： | 1 |
| 12 | Production of eicosapentaenoic and arachidonic acids by an antarctic bacterium: response to growth temperature显示文摘 | David SN Janelle LB Peter DN etal | 1997 | FEMS Microbiology Letters1997，152，2： | 1 |
| 13 | Longterm follow-up after curative surgery for early gastric lymphoma显示文摘 | David LB Martin SK Daniel AF | 1996 | Ann Surg1996，223，1： | 1 |
| 14 | Brain Choline Acetyltransferase and Mental Function in Alzheimer Disease 显示文摘 | David SB Jeffrey LB Francis JP | 1999 | Arch Neurol1999，56，： | 1 |
| 15 | Studying learning in the worldwide classroom:Research into edX’s first MOOC显示文摘 | Breslow LB David E Pritchard Jennifer De Boer | 2013 | Research&Practice in Assessment2013，，8： | 1 |
| 16 | Instrument Scan Strategies of F-117A Pilots 显示文摘 | David LB Holly SV Paul AW | 2002 | Aviat Space Environ Med2002，73，10： | 1 |
| 17 | Outbreak detection through automated surveillance:a review of the determinants of detection显示文摘 | David LB | 2007 | J Biomed Inform2007，40，4： | 1 |
| 18 | Role of the riparian zone in controlling the distribution and fate d agricultural nitrogen near a small stream in southern Ontario显示文摘 | Cey EE David LB Aravena R | 1999 | Journal of Contaminant Hydrology1999，37，： | 1 |
| 19 | Treatment planning evaluation of non-coplanar techniques for conformal radiotherapy of the prostate显示文摘 | James LB Anthony JH David PD | 2005 | Radiother Oncol2005，75，3： | 1 |
| 20 | Transbronchial needle aspiration staging of bronchgenic carcinoma 显示文摘 | David A Jeffrey HB Charies LB | 1986 | Am Rev Respir Dis1986，134，： | 1 |
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