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| 1 | 河南省耐多药与非耐多药肺结核病患者9年生存比较分析显示文摘目的比较河南省耐多药结核病(MDR—TB)和非MDR—TB患者9年后生存情况。方法利用2001年WHO结核病耐药监测数据库中河南省数据,并随机抽取入选病例。于2010年使用调查县结核病防治部门采用问卷访谈形式登记的患者资料、治疗记录等,调查MDR-TB和非MDR-TB患者的生存情况,数据分析采用单因素和多因素logistic统计方法。结果MDR.TB患者9年后的病死率是非MDR-TB患者的2倍,两组间差异有统计学意义。与非MDR-TB相比,MDR-TB患者更多死于结核病。影响结核病患者生存的主要危险因素是年龄、耐多药状态、复治、曾经住院治疗和治疗时间〉1年。与非MDR—TB患者相比,MDR-TB患者平均生存时间减少1.3年。结论MDR-TB对结核病患者的生存有显著影响,特别是MDR—TB的青壮年患者。 | 孙燕妮 王国杰 甄新安 刘占峰 David Harley Gillian Hall Hassan Vally Adrian Sleigh | 2013 | 中华流行病学杂志2013，34，2： | 8 |
| 2 | Lean heart: Role of leptin in cardiac hypertrophy and metabolism显示文摘Leptin is an adipokine that has been linked with the cardiovascular complications resulting from obesity such as hypertension and heart disease. Obese patients have high levels of circulating leptin due to increased fat mass. Clinical and population studies have correlated high levels of circulating leptin with the development of cardiac hypertrophy in obesity. Leptin has also been demonstrated to increase the growth of cultured cardiomyocytes. However, several animal studies of obese leptin deficient mice have not supported a role for leptin in promoting cardiac hypertrophy so the role of leptin in this pathological process remains unclear. Leptin is also an important hormone in the regulation of cardiac metabolism where it supports oxidation of glucose and fatty acids. In addition, leptin plays a critical role in protecting the heart from excess lipid accumulation and the formation of toxic lipids in obesity a condition known as cardiac lipotoxicity. This paper focuses on the data supporting and refuting leptin's role in promoting cardiac hypertrophy as well as its important role in the regulation of cardiac metabolism and protection against cardiac lipotoxicity. | Michael E Hall Romain Harmancey David E Stec | 2015 | World Journal of Cardiology2015，7，9： | 7 |
| 3 | 河南省耐多药和非耐多药结核病对患者社会生活影响的比较显示文摘目的调查研究并比较河南省耐多药结核病(MDR-TB)和非耐多药结核病(非MDR-TB)对患者社会生活的影响,为制订综合有效的结核病防治策略提供科学依据。方法利用2001年河南省参加世界卫生组织结核病耐药监测调查患者数据库,采用Excel生成随机数字表方法随机抽取入选患者。使用问卷面对面访谈形式于2010年对MDR-TB患者和非MDR-TB患者的社会经济状况及结核病相关情况进行访谈性调查研究;共调查访谈234例TB患者。按照对异烟肼和利福平的耐药状态分为暴露组(MDR-TB患者组)86例和对照组(非MDR-TB患者组)148例。对收集的数据进行t检验和卡方检验。结果暴露组(70.9%,61/86)对患结核病的态度比对照组(52.4%,77/148)明显悲观,两组间差异有统计学意义(χ2=8.58,P=0.01)。与对照组比较(2.0%,3/148),更多暴露组患者在患病期间依旧外出打工(9.3%,8/86),两组间差异有统计学意义(χ2=6.43,P=0.01)。结核病治愈后暴露组外出打工的比例(8.8%,7/80)明显低于对照组(24.0%,35/146),两组间差异有统计学意义(χ2=7.92,P<0.01)。与对照组相比(18.9%,28/148),更多暴露组患者患结核病后仍吸烟(34.9%,30/86),两组间差异有统计学意义(χ2=7.44,P<0.01)。更高比率的暴露组患者报告其未来生活计划被患结核病所改变(45.8%,33/72),相比之下23.9%(27/113)的对照组报告其未来生活计划被改变,两组间差异有统计学意义(χ2=11.67,P<0.01)。结论与对照组患者相比,暴露组患者在患病后的社会生活受到明显影响。因此,建议为更加有效的控制结核病尤其是耐多药结核病,应进一步加强对MDR-TB患者的社会支持。 | 孙燕妮 王国杰 甄新安 刘占峰 Harley David Hall Gillian Vally Hassan Sleigh Adrian | 2013 | 中国防痨杂志2013，35，1： | 5 |
| 4 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 5 | 河南省耐多药和非耐多药结核病患者经济状况及相关费用的比较显示文摘目的调查研究并比较河南省耐多药结核病(multidrug-resistant tuberculosis,MDR-TB)和非耐多药结核病(非MDR-TB)患者社会经济情况及相关治疗花费。方法利用2001年河南省参加世界卫生组织结核病耐药监测调查患者数据库,采用Excel生成随机数字表方法随机抽取入选病例。使用问卷访谈形式于2010年对MDR-TB患者和非MDR-TB患者的社会经济状况及结核病相关治疗花费进行访谈性调查研究;共调查访谈234例患者。按照对异烟肼和利福平的耐药状态分为暴露组(MDR-TB患者组)86例和对照组(非MDR-TB患者组)148例。对收集的数据进行t检验和卡方检验。结果暴露组MDR-TB患者家庭年收入低于5000元的比例(55.3%,47/85)明显高于对照组非MDR-TB患者(38.1%,56/147),两组间差异有统计学意义(χ2=6.9,P=0.031)。与同社区其他居民家庭经济情况进行比较:暴露组患者家庭经济情况位于同社区家庭经济水平下1/3等的比例为47.1%(40/85),明显高于对照组32.9%(48/146),两组间差异有统计学意义(χ2=4.6,P=0.032)。与对照组比较,暴露组家庭≤3间的可住房间数的比例明显偏高,分别为37.8%(31/82)和17.9%(26/145),两组间差异有统计学意义(χ2=11.0,P=0.004)。更高比例的暴露组家庭因结核病治疗借款,占19.0%(15/79),对照组占4.5%(6/134),且不能按时偿还(χ2=13.4,P=0.001)。与非MDR-TB患者相比,更高比例的MDR-TB患者在结核病相关治疗花费上支付10 000元以上分别30.2%(26/86)和9.5%(14/148),两组间差异有统计学意义(χ2=19.7,P=0.001)。结论结核病对MDR-TB患者和非MDR-TB患者的社会经济情况有不同程度影响。相比非MDR-TB患者,MDR-TB患者家庭更加贫穷,同时在治疗花费上支出较大。 | 孙燕妮 王国杰 甄新安 刘占峰 Harley David Hall Gillian Vally Hassan Sleigh Adrian | 2012 | 中国防痨杂志2012，34，12： | 4 |
| 6 | Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas显示文摘Pancreatic cancer is one of the deadliest cancers with a very poor prognosis. Recently, there has been a significant increase in research directed towards identifying potential biomarkers that can be used to diagnose and provide prognostic information for pancreatic cancer. These markers can be used clinically to optimize and personalize therapy for individual patients. In this review, we focused on 3 biomarkers involved in the DNA damage response pathway and the necroptosis pathway: Chromodomainhelicase-DNA binding protein 5, chromodomain-helicaseDNA binding protein 7, and mixed lineage kinase domain-like protein. The aim of this article is to review present literature provided for these biomarkers and current studies in which their effectiveness as prognostic biomarkers are analyzed in order to determine their future use as biomarkers in clinical medicine. Based on the data presented, these biomarkers warrant further investigation,and should be validated in future studies. | Crystal S Seldon Lauren E Colbert William A Hall Sarah B Fisher David S Yu Jerome C Landry | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 7 | Metabolic responses of Eucalyptus species to different temperature regimes显示文摘Species and hybrids of Eucalyptus are the world's most widely planted hardwood trees. They are cultivated across a wide range of latitudes and therefore environmental conditions. In this context, comprehensive metabolomics approaches have been used to assess how different temperature regimes may affect the metabolism of three species of Eucalyptus, E. dunnii, E. grandis and E. pellita.Young plants were grown for 53 d in the greenhouse and then transferred to growth chambers at 10°C, 20°C or30°C for another 7 d. In all three species the leaf chlorophyll content was positively correlated to temperature, and in E.pellita the highest temperature also resulted in a significant increase in stem biomass. Comprehensive metabolomics was performed using untargeted gas chromatography mass spectrometry(GC-MS) and liquid chromatography(LC)-MS.This approach enabled the comparison of the relativeabundance of 88 polar primary metabolites from GC-MS and625 semi-polar secondary metabolites from LC-MS. Using principal components analysis, a major effect of temperature was observed in each species which was larger than that resulting from the genetic background. Compounds mostly affected by temperature treatment were subsequently selected using partial least squares discriminant analysis and were further identified. These putative annotations indicated that soluble sugars and several polyphenols, including tannins, triterpenes and alkaloids were mostly influenced. | Joao Benhur Mokochinski Paulo Mazzafera Alexandra Christine Helena Frankland Sawaya Roland Mumm Ric Cornelis Hendricus de Vos Robert David Hall | 2018 | Journal of Integrative Plant Biology2018，60，5： | 2 |
| 8 | Increased Rate of Spontaneous Bacterial Peritonitis Among Cirrhotic Patients Receiving Pharmacologic Acid Suppression显示文摘 | Gati A. Goel Abhishek Deshpande Rocio Lopez Geraldine S. Hall David van Duin William D. Carey | 2012 | Clinical Gastroenterology and Hepatology2012，，4： | 2 |
| 9 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 10 | Is public R&D a complement or substitute for private R&D? A review of the econometric evidence显示文摘 | Paul A. David Bronwyn H. Hall Andrew A. Toole | 2000 | Research Policy2000，，4： | 2 |
| 11 | TheAzolla-Anabaena association: Historical perspective, symbiosis and energy metabolism显示文摘 | Ding-Ji Shi David O. Hall | 1988 | The Botanical Review1988，，4： | 1 |
| 12 | Helicobacter pylori Genotypes in Israeli Children: The Significance of Geography显示文摘 | Shmuel Benenson David Halle Bernard Rudensky Joseph Faber Yechiel Schlesinger David Branski Nina Rabinowitz Michael Wilschanski | 2002 | Journal of Pediatric Gastroenterology and Nutrition2002，，5： | 1 |
| 13 | Substituted cyclic iraides as potential antigout agents 显示文摘 | Iris H Hall John P Scoville David J | 1990 | Life Sciences1990，46，26： | 1 |
| 14 | Algorithms for analyzing no stationary time series with fractal noise显示文摘 | David Matthews Eckhard Platen | 1996 | Journal of Computational and Graphical Statistics1996，，5： | 1 |
| 15 | Is Public R&D a Com- plement or Substitute for Private R&D? A Review of the Econometric Evidence 显示文摘 | David P A Hall B H Toole A A | 2000 | Research Policy2000，29，45： | 1 |
| 16 | Is public R&D a com- plement or substitute for private R&D? a review of econ- ometric evidence 显示文摘 | David P A Hall B H Toole A | 2000 | Research Policy2000，29，4： | 1 |
| 17 | Specific exercises to treat pregnancy-related low back pain in a South African population显示文摘 | Judith Kluge David Hall Quinette Louw Gerhard Theron Debbie Grové | 2011 | International Journal of Gynecology and Obstetrics2011，，3： | 1 |
| 18 | Biogeography of the Indo-Australian Archipelago显示文摘 | David J. Lohman Mark de Bruyn Timothy Page Kristina von Rintelen Robert Hall Peter K.L. Ng Hsi-Te Shih Gary R. Carvalho Thomas von Rintelen | 2011 | Annual Review of Ecology, Evolution, and Systematics2011，，： | 1 |
| 19 | Dynamic optical imaging of metabolic and NADPH oxidase-derived superoxide in live mouse brain using fluorescence lifetime nnmixing显示文摘 | David J Hall Sung-Ho Han | 2012 | Journal of Cerebral Blood Flow & Metabolism2012，32，： | 1 |
| 20 | Compiler Research:The Next 50 Years显示文摘 | Mary Hall David Padu Keshav Pingali | 2009 | Communication of the ACM2009，52，2： | 1 |
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