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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Acute heart failure in elderly patients:a review of invasive and non-invasive management显示文摘Acute heart failure(AHF)is a major cause of unplanned hospitalisations in the elderly and is associated with high mortality.Its prevalence has grown in the last years due to population aging and longer life expectancy of chronic heart failure patients.Although international societies have provided guidelines for the management of AHF in the general population,scientific evidence for geriatric patients is often lacking,as these are underrepresented in clinical trials.Elderly have a different risk profile with more comorbidities,disability,and frailty,leading to increased morbidity,longer recovery time,higher readmission rates,and higher mortality.Furthermore,therapeutic options are often limited,due to unfeasibility of invasive strategies,mechanical circulatory support and cardiac transplantation.Thus,the in-hospital management of AHF should be tailored to each patient's clinical situation,cardiopulmonary condition and geriatric assessment.Palliative care should be considered in some cases,in order to avoid unnecessary diagnostics and/or treatments.After discharge,a strict follow-up through outpatient clinic or telemedicine is can improve quality of life and reduce rehospitalisation rates.The aim of this review is to offer an insight on current literature and provide a clinically oriented,patient-tailored approach regarding assessment,treatment and follow-up of elderly patients admitted for AHF. | Gregorio Tersalvi Alessio Gasperetti Marco Schiavone Jeroen Dauw Cecilia Gobbi Marialessia Denora Joel Daniel Krul Giacomo Maria Cioffi Gianfranco Mitacchione Giovanni B.Forleo | 2021 | Journal of Geriatric Cardiology2021，18，7： | 4 |
| 3 | Biomechanical and morphological corneal response to placement of intrastromal corneal ring segments for keratoconus显示文摘 | Caroline Dauwe David Touboul Cynthia J. Roberts Ashraf M. Mahmoud Julien Kérautret Pierre Fournier Fran?ois Malecaze Joseph Colin | 2009 | Journal of Cataract & Refractive Surgery2009，，10： | 1 |
| 4 | Geometrical simulation of the EDM die-sinking process显示文摘 | TRICARICO C DELPRETrI R DAUW D F | 1988 | CIRP An- nals Manufacturing Technology1988，37，1： | 1 |
| 5 | An active renal crystal clearance mechanism in rat and man显示文摘 | VERVAET BA VERHULST A DAUWE SE | 2009 | Kidney Int2009，75，1： | 1 |
| 6 | Effectiveness of antiretro-viral therapy and development of drug resistance in HIV-1 infected patients in Mombasa,Kenya显示文摘 | Steegen K Luchters S Dauwe K | | 0，，： | 1 |
| 7 | Stem cell therapy for the treatment of myocardial infarction显示文摘 | Dauwe D F Janssens S P | 2011 | Curr Pharm Des2011，17，30： | 1 |
| 8 | TIMP-1 gene expression and PAI -1 antigen after unilateral ureteral obstrution in the adult male rat显示文摘 | Duymelinck C Dauwe SE De Greef KE | 2000 | Kidney Int2000，58，： | 1 |
| 9 | Influence of template basicity and hydrophobicity on the molecular recognition properties of molecularly imprinted polymers显示文摘 | DAUWE C SELLERGREN B | 1996 | J Chromatogr A1996，753，： | 1 |
| 10 | Anti-B7-1 blocks mononuclear cell adherence in vasa recta after ischemia显示文摘 | de Greef K E Ysebaert D K Dauwe S | 2001 | Kidney int2001，60，4： | 1 |
| 11 | Endochondral bone formation is involved in media calcification in rats and in men显示文摘 | Neven E Dauwe S De Broe ME | 2007 | Kidney Int2007，72，： | 1 |
| 12 | An active renal crystal clearance mechanism in rat and man显示文摘 | Vervaet BA Verhulst A Dauwe SE | 2009 | Kidney Int2009，75，： | 1 |
| 13 | Compositon and self-irradiation effects on the positron annihilation lifetime properties of poly (ethylene-co-vinyl acetate)显示文摘 | Balcaen N J de Baerdemaeker C Dauwe | 2000 | Radiation Physics and Chemistry2000，58，： | 1 |
| 14 | Linking diagenetic alteration of amino acids and bulk organic matter reactivity 显示文摘 | Dauwe B Middelburg J J Herman P M J Heip C H R | 1999 | Limnol Oceanogr1999，44，7： | 1 |
| 15 | Endo- chondral bone formation is involved in media calcifica- tion in rats and in men 显示文摘 | NEVEN E DAUWE S DEBROE M E | 2007 | KidneyInt2007，72，： | 1 |
| 16 | Linking diagenetic alteration of amino acids and bulk organic matter reactivity显示文摘 | DAUWE B MIDDELBUR J J HERMAN P M J | 1999 | Limnology and Oceanography1999，44，7： | 1 |
| 17 | Downregulation of cinnamoyl-coenzyme areductase in poplar:multiple-level phenotyping reveals effects on cell wall polymer metabolism and structure显示文摘 | LEPLJ C DAUWE R MORREEL K | 2007 | The Plant Cell2007，19，： | 1 |
| 18 | Elevated salinity selects for a less diverse ammonia-oxidizing population in aquarium biofibers显示文摘 | Grommen R Dauw L Verstraete W | 2005 | FEMS Microbiology Eeology2005，，52： | 1 |
| 19 | Chondro- cyte rather than osteoblast conversion of vascular cells underlies medial calcification in uremic rats 显示文摘 | NEVEN E PERSY V DAUWE S | 2010 | Arte- rioscler Thromb Vascular Biol2010，30，： | 1 |
| 20 | TIMP-1 gene expression and PAI-1 antigen after unilateral ureteral obstrution in the adult male rat显示文摘 | Duymelinck C Dauwe SE De Greef KE | 2000 | Kidney Int2000，58，： | 1 |
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