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| 1 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 2 | Surgical ampullectomy:A comprehensive review显示文摘Tumours of the ampulla of Vater are relatively uncommon lesions of the digestive system.They are typically diagnosed at an earlier stage than other types of tumours in this region,due to their tendency to invoke symptoms by obstructing the bile duct or pancreatic duct.Consequently,many are potentially curable by excision.Surgical ampullectomy(SA)(or transduodenal ampullectomy)for an ampullary tumour was first described in 1899,but was soon surpassed by pancreatoduodenectomy(PD),which offered a more extensive resection resulting in a lower risk of recurrence.Ongoing innovation in endoscopic techniques over recent decades has led to the popularization of endoscopic papillectomy(EP),particularly for adenomas and even early cancers.The vast majority of resectable ampullary tumours are now treated using either PD or EP.However,SA continues to play a role in specific circumstances.Many authors have suggested specific indications for SA based on their own data,practices,or interpretations of the literature.However,certain issues have attracted controversy,such as its use for early ampullary cancers.Consequently,there has been a lack of clarity regarding indications for SA,and no evidence-based consensus guidelines have been produced.All studies reporting SA have employed observational designs,and have been heterogeneous in their methodologies.Accordingly,characteristics of patients and their tumours have differed substantially across treatment groups.Therefore,meaningful comparisons of clinical outcomes between SA,PD and EP have been elusive.Nevertheless,it appears that suitably selected cases of ampullary tumours subjected to SA may benefit from favourable peri-operative and long-term outcomes with very low mortality and significantly long survival,hence its role in this setting warrants further clarification,while it can also be useful in the management of specific benign entities.Whilst the commissioning of a randomised controlled trial seems unlikely,well-designed observational studies incorporating adjustments for confounding variables may become the best available comparative evidence for SA,potentially informing the eventual development of consensus guidelines.In this comprehensive review,we explore the role of SA in the modern management of ampullary lesions. | Darren L Scroggie Vasileios K Mavroeidis | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 3 | Implementation of a Cooperative Navigation Algorithm on a Platoon of Autonomous Underwater Vehicles显示文摘 | Darren K M Aditya S G Daniel J | | 0，，： | 1 |
| 4 | Removal of inorganic constituents of biomass Feedstocks by mechanical dewatering and leaching 显示文摘 | SCOTT Q T CHARLES M K DARREN M | 1997 | Biomass and Bioenergy1997，12，4： | 1 |
| 5 | Diagnosis of breast tumors with sonographic texture analysis using wavelet transform and neural networks显示文摘 | Darren C Rueyfeng C Wenjia K | 2002 | Ultrasound in Med Biol2002，28，10： | 1 |
| 6 | The application of the potassiumtitanyl-phosphate (KTP) laser in the management of subglottic hemangioma显示文摘 | David M Syed F Darren K | 2001 | Arch Otolaryngol Head Neck Surg2001，127，1： | 1 |
| 7 | Outcomes following liver transplantation in intensive care unit patients显示文摘AIM:To determine feasibility of liver transplantation in patients from the intensive care unit (ICU) by estimating graft and patient survival.METHODS:This single center retrospective study included 39 patients who had their first liver transplant directly from the intensive care unit and 927 non-ICU patients who were transplanted from hospital ward or home between January 2005 and December 2010.RESULTS:In comparison to non-ICU patients,ICU patients had a higher model for end-stage liver disease (MELD) at transplant (median:37 vs 20,P < 0.001).Fourteen out of 39 patients (36%) required vasopressor support immediately prior to liver transplantation (LT) with 6 patients (15%) requiring both vasopressin and norepinephrine.Sixteen ICU patients (41%) were ventilator dependent immediately prior to LT with 9 patients undergoing percutaneous tracheostomy prior to transplantation.Twenty-five ICU patients (64%) required dialysis preoperatively.At 1,3 and 5 years after LT,graft survival was 76%,68% and 62% in ICU patients vs 90%,81% and 75% in non-ICU patients.Patient survival at 1,3 and 5 years after LT was 78%,70% and 65% in ICU patients vs 94%,85% and 79% in non-ICU patients.When formally comparing graft survival and patient survival between ICU and nonICU patients using Cox proportional hazards regression models,both graft survival [relative risk (RR):1.94,95%CI:1.09-3.48,P=0.026] and patient survival (RR:2.32,95%CI:1.26-4.27,P=0.007) were lower in ICU patients vs non-ICU patients in single variable analysis.These findings were consistent in multivariable analysis.Although not statistically significant,graft survival was worse in both patients with cryptogenic cirrhosis (RR:3.29,P=0.056) and patients who received donor after cardiac death (DCD) grafts (RR:3.38,P=0.060).These findings reached statistical significance when considering patient survival,which was worse for patients with cryptogenic cirrhosis (RR:3.97,P=0.031) and patients who were transplanted with DCD livers (RR:4.19,P=0.033).Graft survival and patient survival were not significantly worse for patients on mechanical ventilation (RR:0.91,P=0.88 in graft loss;RR:0.69,P=0.56 in death) or patients on vasopressors (RR:1.06,P=0.93 in graft loss;RR:1.24,P=0.74 in death) immediately prior to LT.Trends toward lower graft survival and patient survival were observed for patients on dialysis immediately before LT,however these findings did not approach statistical significance (RR:1.70,P=0.43 in graft loss;RR:1.46,P=0.58 in death).CONCLUSION:Although ICU patients when compared to non-ICU patients have lower survivals,outcomes are still acceptable.Pre-transplant ventilation,hemodialysis,and vasopressors were not associated with adverse outcomes. | Lena Sibulesky Michael G Heckman C Burcin Taner Juan M Canabal Nancy N Diehl Dana K Perry Darren L Willingham Surakit Pungpapong Barry G Rosser David J Kramer Justin H Nguyen | 2013 | World Journal of Hepatology2013，5，1： | 1 |
| 8 | B-type natriuretic peptide in cardiovascular disease 显示文摘 | James A de Lemos Darren K McGuire Mark H Drazner | 2003 | Lancet2003，362，： | 1 |
| 9 | The fate inorganic constituents of biomass in fluidized bed gasification显示文摘 | Scott Q T Charles M K Darren M I | 1998 | Fuel1998，77，3： | 1 |
| 10 | Removal of inorganic constituents of biomass feedstocks by mechanical dewatering and leaching显示文摘 | SCOTT Q T CHARLES M K DARREN M I | 1997 | Biomass and Bioenergy1997，12，4： | 1 |
| 11 | Removal of inorganic constituents of biomass feedstocks by mechanical dewatering and leaching 显示文摘 | Scott Q T Charles M K Darren M I | 1997 | Biomass and Bioenergy1997，12，4： | 1 |
| 12 | Fouling mechanism and resistance analyses of systems containing sodium alginate,calcium,alum and their combination in dead-end fouling of nanofiltration membranes显示文摘 | Listiarini K Chun W Darren D | | 0，，1： | 1 |
| 13 | Organic fouling of nanofiltration membranes:Evaluating the effects of humic acid,calcium,alum coagulant and their combinations on the specific cake resistance显示文摘 | Listiarini K Darren D James O | | 0，，1： | 1 |
| 14 | A microfluidic system combining acoustic and dielectrophoretic particle preconcentration and focusing显示文摘 | SURENDRA K R DARREN W B CONRAD D J | 2008 | Sensors and Actuators B:Chemical2008，130，2： | 1 |
| 15 | Alabeling method for dynamic driver-task assignment with uncertain task durations显示文摘 | Raymond K C Darren D H Ning S | 2005 | Operations Research Letters2005，33，： | 1 |
| 16 | Special perforated steel plate shear walls with reduced beam section anchor beams, i : Experimental investigation 显示文摘 | Darren Vian M ASCE Michel Bruneau M ASCE Tsai K C | 2009 | Joumal of Structural Engineering2009，135，3： | 1 |
| 17 | Removal of inorganic constituents of biomass feedstocks by mechanical dewatering and leaching 显示文摘 | SCOTT Q T CHARLES M K DARREN M I | 1997 | Biomass and Bioenergy1997，，4： | 1 |
| 18 | Robust neural network control of rigid link electrically driven robots 显示文摘 | Chiman K Frank L L Darren M D | 2000 | IEEE Transactions on Systems Man and Cybernetics2000，30，6： | 1 |
| 19 | Temperature-composi- tion-time(T-X-t) data from authigenic K-feldspar: An inte- grated methodology for dating fluid flow events显示文摘 | Darren F M John P Simon P K | 2006 | Journal of Geochemical Exploration2006，89，： | 1 |
| 20 | Impaired glucose tolerance and impaired fasting glucose-a review of diagnosis,clinical implications and management显示文摘 | Hn L Petersen Darren K McGuire | 2005 | Dabetes and Vascular Disease Research2005，2，1： | 1 |
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