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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | Cefditoren Pivoxil显示文摘 | Darkes Mj Plosker GL | 2002 | Drugs2002，62，2： | 2 |
| 3 | Meiosis in diploid and tetraploid Paeonia species显示文摘 | Dark S D S | 1936 | J Genet1936，32，： | 2 |
| 4 | One-tube HLA-B27/B2708 typing by flow cytometry using two ' Anti-HLA-B27 ' monoclonal antibody reagents显示文摘 | Darke C Coates E | | 0，，： | 1 |
| 5 | Underwriter reputation,initial returns,and the long-run performance of IPO stocks显示文摘 | Carter R Dark F Singh A | | 0，，53： | 1 |
| 6 | Sleep spindles in epilepsy显示文摘 | Darke ME Jr Pakalnis A Padamadan H | 1997 | Clin Electroencephalogr1997，22，3： | 1 |
| 7 | Vaccination with autologons tumer antigen-pulsed dentrbutic cells in advanced gynecological malignancies,clinical and immunological evaluation of a phase Ⅰtrial显示文摘 | HAMAM D O J J DARK T W KUBLERK | 2002 | Cancer Immunol2002，51，1： | 1 |
| 8 | Under-writer reputation,initial returns,and the long-run performance of IPO stocks显示文摘 | Carter R. B Dark F. H Singh A. K | | 0，，01： | 1 |
| 9 | Combretastatin A -4, an agent that displays potent and selective toxicity toward tumor vasculature显示文摘 | Dark GG Hil SA Prise VE | 1997 | Cancer Res1997，57，： | 1 |
| 10 | Landscape change and habitat availability in the southern highlands and Olympic Peninsula显示文摘 | Pearson S M Turner M G Darke J B | 1999 | Ecological Applications1999，9，4： | 1 |
| 11 | Combretastatin A-4,an agent that displays potent and selective toxicity toward tumor vasculature显示文摘 | Dark GG Hill SA Prise VE | 1997 | Cancer Res1997，57，10： | 1 |
| 12 | The biosynthesis of trisporic acids from β-Carotene via retinal and trisporol 显示文摘 | Austin D J J D Bullock D Darke | 1970 | Experientia1970，26，： | 1 |
| 13 | Estimation of time varying skewness and kurtosis with an application to value-at-risk显示文摘 | Dark J G | | 0，，03： | 1 |
| 14 | The effect of HLA - DR genes on susceptibility to and severity of ankylosing spondylitis 显示文摘 | Brown MA Kennedy LG Darke C | 1998 | Arthritis Rheum1998，41，： | 1 |
| 15 | Dangerous drug interactions leading to hemolytic uremic syndrome following lung transplantation显示文摘 | Parissis H Gould K Dark J | 2010 | J Cardiothorac Surg2010，5，： | 1 |
| 16 | Combretastatin A -4, an agent that displays potent and selective toxicity toward tumor vasculature 显示文摘 | Dark GG Hill SA Prise VE | 1997 | Cancer Res1997，57，： | 1 |
| 17 | Patterns of major depression and drug-related problems amongst heroin users across 36 months显示文摘 | Darke S Mills K Teesson M | 2009 | Psychiatry Res2009，166，1： | 1 |
| 18 | Cocaine-related fatalities in New South Wales, Australia 1993-2002 显示文摘 | Darke S Kaye S Duflou J | 2005 | Drug Alcohol Dep2005，77，2： | 1 |
| 19 | Discrete Hough transform using line segment rep- resentation for line detection显示文摘 | LEE D DARK Y | 2011 | Optical Engineering2011，50，8： | 1 |
| 20 | Cardiac measurements on thoracic radio graphs of cats显示文摘 | van den Broek Darke | 1987 | Journal of the Small Animal Practice1987，28，1： | 1 |
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