|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exercise-induced irisin in bone and systemic irisin administration reveal new regulatory mechanisms of bone metabolism显示文摘Irisin is a polypeptide hormone derived from the proteolytic cleavage of fibronectin-type III domaincontaining 5(FNDC5) protein. Once released to circulation upon exercise or cold exposure, irisin stimulates browning of white adipose tissue(WAT) and uncoupling protein 1(UCP1) expression, leading to an increase in total body energy expenditure by augmented UCP1-mediated thermogenesis. It is currently unknown whether irisin is secreted by bone upon exercise or whether it regulates bone metabolism in vivo. In this study, we found that 2 weeks of voluntary wheel-running exercise induced high levels of FNDC5 messenger RNA as well as FNDC5/irisin protein expression in murine bone tissues. Increased immunoreactivity due to exercise-induced FNDC5/irisin expression was detected in different regions of exercised femoral bones,including growth plate, trabecular bone, cortical bone, articular cartilage, and bone–tendon interface. Exercise also increased expression of osteogenic markers in bone and that of UCP1 in WAT, and led to bodyweight loss. Irisin intraperitoneal(IP) administration resulted in increased trabecular and cortical bone thickness and osteoblasts numbers, and concurrently induced UCP1 expression in subcutaneous WAT. Lentiviral FNDC5 IP administration increased cortical bone thickness. In vitro studies in bone cells revealed irisin increases osteoblastogenesis and mineralization, and inhibits receptor activator of nuclear factor-k B ligand(RANKL)-induced osteoclastogenesis. Taken together, our findings show that voluntary exercise increases irisin production in bone, and that an increase in circulating irisin levels enhances osteogenesis in mice. | Jin Zhang Paloma Valverde Xiaofang Zhu Dana Murray Yuwei Wu Liming Yu Hua Jiang Michel M Dard Jin Huang Zhiwei Xu Qisheng Tu Jake Chen | 2017 | Bone Research2017，5，1： | 23 |
| 2 | Stagnant lids and mantle overturns:Implications for Archaean tectonics, magmagenesis,crustal growth, mantle evolution, and the start of plate tectonics显示文摘The lower plate is the dominant agent in modern convergent margins characterized by active subduction,as negatively buoyant oceanic lithosphere sinks into the asthenosphere under its own weight.This is a strong plate-driving force because the slab-pull force is transmitted through the stiff sub-oceanic lithospheric mantle.As geological and geochemical data seem inconsistent with the existence of modernstyle ridges and arcs in the Archaean,a periodically-destabilized stagnant-lid crust system is proposed instead.Stagnant-lid intervals may correspond to periods of layered mantle convection where efficient cooling was restricted to the upper mantle,perturbing Earth's heat generation/loss balance,eventually triggering mantle overturns.Archaean basalts were derived from fertile mantle in overturn upwelling zones(OUZOs),which were larger and longer-lived than post-Archaean plumes.Early cratons/continents probably formed above OUZOs as large volumes of basalt and komatiite were delivered for protracted periods,allowing basal crustal cannibalism,garnetiferous crustal restite delamination,and coupled development of continental crust and sub-continental lithospheric mantle.Periodic mixing and rehomogenization during overturns retarded development of isotopically depleted MORB(mid-ocean ridge basalt)mantle.Only after the start of true subduction did sequestration of subducted slabs at the coremantle boundary lead to the development of the depleted MORB mantle source.During Archaean mantle overturns,pre-existing continents located above OUZOs would be strongly reworked;whereas OUZOdistal continents would drift in response to mantle currents.The leading edge of drifting Archaean continents would be convergent margins characterized by terrane accretion,imbrication,subcretion and anatexis of unsubductable oceanic lithosphere.As Earth cooled and the background oceanic lithosphere became denser and stiffer,there would be an increasing probability that oceanic crustal segments could founder in an organized way,producing a gradual evolution of pre-subduction convergent margins into modern-style active subduction systems around 2.5 Ga.Plate tectonics today is constituted of:(1)a continental drift system that started in the Early Archaean,driven by deep mantle currents pressing against the Archaean-age sub-continental lithospheric mantle keels that underlie Archaean cratons;(2)a subduction-driven system that started near the end of the Archaean. | Jean H.Bédard | 2018 | Geoscience Frontiers2018，9，1： | 21 |
| 3 | 旅游规划的战略工具:全球可持续旅游目的地标准显示文摘可持续旅游正在兴起,旅游者需求不断增长,旅游经营者正在开发新的绿色旅游产品,各国政府以及国际机构正在制定新政策,以鼓励可持续旅游的发展。然而,“可持续旅游”的真正含义是什么?从获得旅游者信任、促进旅游业繁荣、带动社区发展到避免“可持续旅游”变成被到处乱贴的标签,我们该怎样寻求一种可信而正确的界定方法与评价依据呢?本文基于全球可持续旅游目的地标准工作组近年来的研究结果,尤其是目的地课题组的研究,探索可持续旅游视角下的旅游规划概念和方法。 | Franois Bédard 黄潇婷 | 2013 | 旅游学刊2013，28，9： | 3 |
| 4 | Recombinant amelogenin regulates the bioactivity of mouse cementoblasts in vitro显示文摘Amelogenin(AMG) is a cell adhesion molecule that has an important role in the mineralization of enamel and regulates events during dental development and root formation. The purpose of the present study was to investigate the effects of recombinant human AMG(rhAMG) on mineralized tissue-associated genes in cementoblasts. Immortalized mouse cementoblasts(OCCM-30)were treated with different concentrations(0.1, 1, 10, 100, 1 000, 10 000, 100 000 ng · mL^(-1)) of recombinant human AMG(rhAMG)and analyzed for proliferation, mineralization and mRNA expression of bone sialoprotein(BSP), osteocalcin(OCN), collagen type I(COL I), osteopontin(OPN), runt-related transcription factor 2(Runx2), cementum attachment protein(CAP), and alkaline phosphatase(ALP) genes using quantitative RT-PCR. The dose response of rhAMG was evaluated using a real-time cell analyzer.Total RNA was isolated on day 3, and cell mineralization was assessed using von Kossa staining on day 8. COL I, OPN and lysosomalassociated membrane protein-1(LAMP-1), which is a cell surface binding site for amelogenin, were evaluated using immunocytochemistry. F-actin bundles were imaged using confocal microscopy. rhAMG at a concentration of 100 000 ng · mL^(-1) increased cell proliferation after 72 h compared to the other concentrations and the untreated control group. rhAMG(100 000 ng · mL^(-1)) upregulated BSP and OCN mRNA expression levels eightfold and fivefold, respectively. rhAMG at a concentration of 100 000 ng · mL^(-1) remarkably enhanced LAMP-1 staining in cementoblasts. Increased numbers of mineralized nodules were observed at concentrations of 10 000 and 100 000 ng · mL^(-1) rhAMG. The present data suggest that rhAMG is a potent regulator of gene expression in cementoblasts and support the potential application of rhAMG in therapies aimed at fast regeneration of damaged periodontal tissue. | Sema S.Hakki S.Buket Bozkurt Emre Türkay Michel Dard Nuhan Purali Werner Gotz | 2018 | International Journal of Oral Science2018，10，2： | 3 |
| 5 | Epidemiology of and Diagnostic Strategies for Toxoplasmosis显示文摘 | Florence Robert-Gangneux Marie-Laure Dardé | 2012 | Clinical Microbiology Reviews2012，，3： | 2 |
| 6 | Components of the anti-Müllerian hormone signaling pathway in gonads显示文摘 | N. di Clemente N. Josso L. Gouédard C. Belville | 2003 | Molecular and Cellular Endocrinology2003，，1： | 1 |
| 7 | Effect of immediate or delayed loading following immediate placement of implants with a modified surface显示文摘 | Linares A Mardas N Dard M Donos N | 2010 | Clin Oral Implants Res2010，，： | 1 |
| 8 | Effect of intravenous fructose1,6-diphosphate administration in malnourished chronic obstructive pulmonary disease patients with chronic respiratory failure显示文摘 | Marchesani F Valerio G Dardes N | 2000 | Respiration2000，67，： | 1 |
| 9 | Specific DNA polymorphism discriminate between virulence and nonvirulence to mice in nine Toxoplasma gondii strains显示文摘 | RINDER H THOMSCHKE A DARDE ML | 1995 | Mol Biochem Parasitol1995，69，1： | 1 |
| 10 | Internal rotation of the tibial component is frequent in stiff total knee arthroplasty显示文摘 | Bédard M Vince KG Redfern J | 2011 | 469(8):2346-23552011，469，8： | 1 |
| 11 | Are plants useful as accumulation indicators of metal bioavailability? 显示文摘 | REMON E BOUCHARDON J L LE GU DARD M | 2013 | Environmental Pollution2013，175，： | 1 |
| 12 | Immunomagnetic separation of Toxoplasma gondii oocysts using a monoclonal antibody directed against the oocyst wall显示文摘 | DUMeTRE A DARDe M L | 2005 | Journal of Microbiological Methods2005，61，2： | 1 |
| 13 | Atrazine and simazine removal mechanisms by nanofiltration: Influence of natural organic matter concentration 显示文摘 | Koffi Marcus Agbekodo Bemard Legube Stephane Dard | 1996 | Water Research1996，30，11： | 1 |
| 14 | Differential effects of prostaglandin E(2)and enamel matrix derivative on the proliferation of human gingival and dermal fibroblasts and gingival keratinocytes显示文摘 | Weinberg E Topaz M Dard M | 2010 | J Periodontal Res2010，45，6： | 1 |
| 15 | Wind-induced interference effects on buildings — a review of the state-of-the-art显示文摘 | A.C. Khanduri T. Stathopoulos C. Bédard | 1998 | Engineering Structures1998，，7： | 1 |
| 16 | Palmoplantar keratoderma and skin grafting:postsurgical long-term follow-up of two cases with Olmsted syndrome显示文摘 | Bédard MS Powell J Laberge L | 2008 | Pediatr Dermatol2008，25，2： | 1 |
| 17 | Microsatellite analysis of Toxoplasma gondii shows considerable polymorphism structured into two main clonal groups显示文摘 | Daniel Ajzenberg Anne-Laure Ba?uls Michel Tibayrenc Marie Laure Dardé | 2002 | International Journal for Parasitology2002，，1： | 1 |
| 18 | Ground and excited state properties of carbozole-based dyads:correlation with their respective absorption and fluorescence spectra显示文摘 | Michel Belletete Mélanie Bédard Mario Leclerc | 2004 | Journal of Molecular Structure (TheoChem)2004，679，1： | 1 |
| 19 | Atorvastatin modifies the protein profile of circulating human monocytes after an acute coronary syndrome 显示文摘 | Barderas M G Tunon J Darde V M | 2009 | Proteomics2009，9，7： | 1 |
| 20 | The role of surgery and postoperative chemoradiation therapy in patients with lymph node positive esophageal carcinoma显示文摘 | Eric L. R.Bédard Richard I.Inculet Richard A.Malthaner EdwardBrecevic MarkVincent RashidDar | 2001 | Cancer2001，，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员