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| 1 | High-precision whispering gallery microsensors with ergodic spectra empowered by machine learning显示文摘Whispering gallery mode(WGM)microcavities provide increasing opportunities for precision measurement due to their ultrahigh sensitivity,compact size,and fast response.However,the conventional WGM sensors rely on monitoring the changes of a single mode,and the abundant sensing information in WGM transmission spectra has not been fully utilized.Here,empowered by machine learning(ML),we propose and demonstrate an ergodic spectra sensing method in an optofluidic microcavity for high-precision pressure measurement.The developed ML method realizes the analysis of the full features of optical spectra.The prediction accuracy of 99.97%is obtained with the average error as low as 0.32 kPa in the pressure range of 100 kPa via the training and testing stages.We further achieve the real-time readout of arbitrary unknown pressure within the range of measurement,and a prediction accuracy of 99.51%is obtained.Moreover,we demonstrate that the ergodic spectra sensing accuracy is∼11.5%higher than that of simply extracting resonating modes’wavelength.With the high sensitivity and prediction accuracy,this work opens up a new avenue for integrated intelligent optical sensing. | BING DUAN HANYING ZOU JIN-HUI CHEN CHUN HUI MA XINGYUN ZHAO XIAOLONG ZHENG CHUAN WANG LIANG LIU DAQUAN YANG | 2022 | Photonics Research2022，10，10： | 3 |
| 2 | The velocity structure of the Yinggehai Basin and its hydrocarbon implication显示文摘Two profiles of refraction and wide_angle reflection were completed in the Yinggehai Basin using ocean bottom hydrophones (OBHs) as receiver. These profiles reveal a low velocity layer (LVL) to the west of No. 1 Fault in the basin, with velocity of 3.0-3.5 km/s. Its upper interface lies at 3.5 km below the sea bottom at the NE end of the profiles, and deepens southwestward to 4 6 km near the axis of the basin. It coincides with the top of a gas_bearing, high_pressure layer defined by well logging. This suggests that the LVL is a layer of less_compacted and gas_charged sediments. The lower interface of the LVL is about 9 km in depth. Sediments above the LVL have velocity varying from 2 0 to 4 1 km/s. The acoustic basement is found only east of No. 1 Fault, with velocity of 5 8-6 2 km/s. A NNW_SSE_running OBH seismic profile across the Xisha Trough was completed on the same cruise. Moho and other deep interfaces are clearly visible in the profile. | Kanyuan Xia Di Zhou Daquan Su E. Flueh Sanyu Ye Hanyi He Weidong Chen Yuhong Xie Guixian Wang Saijun Liu et al. | 1998 | Chinese Science Bulletin1998，43，24： | 3 |
| 3 | Identification of Sheep Ovary Genes Potentially Associated with Off-season Reproduction显示文摘Off-season reproduction is a favorable economic trait for sheep industry.Hu sheep,an indigenous Chinese sheep breed,demonstrates a higher productivity of lambs and displays year-around oestrous behavior under proper nutrition and environment.The genetic basis behind these traits,however,is not well understood.In order to identify genes associated with the off-season reproduction,we constructed a suppression subtractive hybridization(SSH) cDNA library using pooled ovary mRNAs of 6 oestrous Hu females as a tester and the pooled ovary mRNAs of 6 non-oestrous Chinese Merino females as a driver.A total of 382 resulting positive clones were obtained after the SSH.We identified 114 differentially up-regulated genes in oestrous Hu sheep by using subsequent screening and DNA sequencing,of which 8 were previously known,93 were reported for the first time in sheep,and 13 were novel with no significant homology to any sequence in the DNA databases.Functions of the genes identified are related to cell division,signal transduction,structure,metabolism,or cell defense.To validate the results of SSH,6 genes(Ntrk2,Ppap2b,Htra1,Nid1,Serpine2 and Foxola) were selected for conformational analysis using quantitative real-time PCR(qRT-PCR),and two of them(Htral and Foxola) were verified by Northern blot.All of the 6 genes were differentially up-regulated in the ovary of oestrous Hu.It is obvious that off-season reproduction is a complex trait involving multiple genes in multiple organs.This study helps to provide a foundation for the final identification of functional genes involved in the sheep ovary. | Lei Chen Ka Liu Zongsheng Zhao Hugh T.Blair Peng Zhang Daquan Li Runlin Z.Ma | 2012 | Journal of Genetics and Genomics2012，39，4： | 3 |
| 4 | 青海河湟谷地胃癌病理特征及其变化趋势分析(英文)显示文摘Objective: The aim of our study was to discuss changes in the clinicopathological characteristics of gastric cancer in Hehuang Valley of China in recent 10 years. Methods: A retrospective case-control study was performed on 2379 newly-diagnosed gastric cancer patients. All of them came from Hehuang Valley. The patients were divided into two groups [recent 5 years(R5Y) and late 5 years(L5Y)] from February 2003 to February 2013, and the clinicopathological data were surveyed retrospectively. Results: The constituent ratio of upper 1/3 gastric cancer in R5Y and L5Y was 33.5% and 20.7%, respectively, and it showed a significant difference between the two groups(χ2 = 21.28, P = 0.00). The constituent ratio of squamous carcinoma/adenosquamous carcinoma was 2.7% and 1.6%, respectively, and it also showed a significant difference between two groups(χ2 = 50.91, P = 0.00). The constituent ratio of moderately-poorly differentiated/poorly differentiated gastric carcinoma was 84.2% and 50.2%, respectively, and it showed statistically significant difference(χ2 = 30.28, P = 0.00). The detection rate of early gastric cancer(EGC) was 1.47%(35/2379). The constituent ratio of the types of Borrmann II and Borrmann IV of advanced gastric cancer(AGC) among 2379 cases was 47.6% and 40.8%, respectively, and that still showed statistically significant difference(χ2 = 18.80, P = 0.00). The constituent ratio of diffuse-type of gastric cancer in R5Y and L5Y was 36.2% and 30.8%, respectively, even there was a significant difference(χ2 = 7.49, P = 0.01). Furthermore, there were also significant differences in regional lymph nodes metastasis, perineural infiltration and vascular invasion(P < 0.05). The positive detection rate of HER2, ER and PR was 14.88%, 17.23% and 15.93%, respectively. The constituent ratio of HP in two groups was 43.8% and 36.2% respectively, and it also showed a significant difference(χ2 = 13.51, P = 0.00). Conclusion: The pathogenic sites in gastric cancer change to the upper stomach in Hehuang Valley in recent 10 years, and the detection rate of squamous carcinoma/adenosquamous carcinoma reveals a sharp rise. Borrmann III is still one of the main types of advanced gastric cancer, but the detection rates of Borrmann II and IV are increasing. The main type of gastric cancer is the intestinaltype, but the ratio of diffuse-type is also increasing in recent 10 years. The HP detection rate is 40.65%(967/2379), and it has a slight rise in recent 10 years. The detection rate of poorly differentiated adenocarcinoma is increasing despite the fact that the moderately/moderately-poorly differentiated adenocarcinoma is the main histologic types. High detection rates of lymph nodes metastasis, perineural infiltration and vascular invasion indicate poor prognosis in patients with gastric cancer. There is no change in HER2 positive rate, on the contrary, there are a little increase in ER and PR expression in Hehuang Valley. | Su Yan Bin Li Junqi Wu Dawei Xie Yingcai Ma Yuanzhi Xiong Xuxiang Ma Xinjian Guo Man Dai Daquan Zhang Xinyang Liu | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，2： | 2 |
| 5 | Photoic crystal nanobeam cavity devices for on-chip integrated silicon photonics显示文摘Integrated circuit(IC)industry has fully considered the fact that the Moore’s Law is slowing down or ending.Alternative solutions are highly and urgently desired to break the physical size limits in the More-than-Moore era.Integrated silicon photonics technology exhibits distinguished potential to achieve faster operation speed,less power dissipation,and lower cost in IC industry,because their COMS compatibility,fast response,and high monolithic integration capability.Particularly,compared with other on-chip resonators(e.g.microrings,2D photonic crystal cavities)silicon-on-insulator(SOI)-based photonic crystal nanobeam cavity(PCNC)has emerged as a promising platform for on-chip integration,due to their attractive properties of ultra-high Q/V,ultra-compact footprints and convenient integration with silicon bus-waveguides.In this paper,we present a comprehensive review on recent progress of on-chip PCNC devices for lasing,modulation,switching/filting and label-free sensing,etc. | Daquan Yang Xiao Liu Xiaogang Li Bing Duan Aiqiang Wang Yunfeng Xiao | 2021 | Journal of Semiconductors2021，42，2： | 2 |
| 6 | A murine model for human immune thrombocytopenic purpura and comparative analysis of multiple gene expression in bone marrow and spleen显示文摘Homeostasis of platelet number in human and other mammals is well maintained for prevention of minor bleeding and for other immunological functions,but the exact molecular mechanism responsible for immune thrombocytopenic purpura(ITP) has not been fully understood.In an effort to identify genetic factors involved in initiation of platelet production in response to bleeding injury or platelet destruction,we have successfully generated an animal model of human ITP via intraperitoneal injection of anti-platelet antibody into the Balb/c mouse.Platelet counts were dropped dramatically in animals that received antibody injection within 4 h,maintained at the mini-mum level for a period of 44 h,started to rebound after 48 h,and reached to the maximum at 144 h(6 days).Final homeostasis reached at approximately 408 h(17 days),following a minor cycle of platelet number fluctuation.Using semi-quantitative RT-PCR,we assessed and compared mRNA level of CD41,c-myb,c-mpl,caspase-3,caspase-9,GATA-1,and Bcl-xl in bone marrow and spleen.Alteration of mRNA expression was correlated with the change of platelet level,and an inverse relationship was found for expression of the genes between bone marrow and spleen.No transcription was detectable for any of the seven genes in bone marrow at the time when platelet number reached the maximum(144 h).In contrast,mRNA transcripts of the seven genes were found to be at the highest level in spleen tissue.This is the first study of simultaneous detection of multiple platelet related genes in a highly reproducible ITP animal model.Our results provided the supportive evidence that expression of the above seven genes are more related to negative regulation of platelet number in spleen tissue,at least in the model animals. | Hong Wei Xinchun Ding Jiangong Ren Ka Liu Pingping Tan Daquan Li Runlin Z. Ma | 2008 | Journal of Genetics and Genomics2008，35，11： | 2 |
| 7 | Imidazolium‐Based Organic–Inorganic Hybrid Silica as a Functional Platform Dramatically Boosts Chiral Organometallics Performance in Asymmetric Catalysis显示文摘 | Daquan Xia Tanyu Cheng Wei Xiao Ketang Liu Zhaoliang Wang Guohua Liu Hexing Li Wei Wang | 2013 | ChemCatChem2013，，7： | 1 |
| 8 | In vivo evaluation of novel chitosan graft polymeric micelles for delivery of paclitaxel 显示文摘 | Jia Liu Hongxia Li Daquan Chen | 2011 | Drug Delivery2011，18，3： | 1 |
| 9 | Ultrahigh electrical conductivities and low lattice thermal conductivities of La,Dy,and Nb Co-doped SrTiO3 thermoelectric materials with complex structures显示文摘Microstructural modifications and appropriate element doping are necessary to simultaneously enhance the electrical conductivities and reduce the lattice thermal conductivities of thermoelectric materials.Herein,we propose a strategy of multielement doping combined with a burial sintering process to promote thermoelectric properties.Three-element doped Sr0.9La0.05Dy0.05Ti1-xNbxO3(x=0,0.05,0.10,0.15,and 0.20)powders were synthesized by high-energy ball milling,and corresponding bulk samples were prepared by carbon burial sintering.In the bulk samples,we obtained the desired microstructures composed of shell-vesicular architectures with dense dislocations and second phase particles.These materials had ultrahigh electrical conductivities(~5300 S cm^-1 at 300 K),low lattice thermal conductivities(~1.6 Wm^-1 K^-1 from 700 to 1100 K when x=0.2)and low total thermal conductivities(minimum value of 2.95 Wm^-1 K^-1 when x=0.05 at 1100 K).The maximum zT values were 0.28 when x=0.05 and 0.27 when x=0.2 at 1100 K.This strategy provides a possible direction for improving the thermoelectric properties of SrTiO3 based materials. | Daquan Liu Yanxia Wang Xue Jiang Huijun Kang Xiong Yang Xiaoying Zhang Tongmin Wang | 2020 | Journal of Materials Science & Technology2020，52，17： | 1 |
| 10 | Photosensitive Self-Assembled Membrane of Cysteine Against Copper Corrosion 显示文摘 | Zhang Daquan Liu Pei-hui Gao Li-xin | 2011 | Mater Lett2011，65，11： | 1 |
| 11 | The seismicity and seismic structure in the seismic risk region from Xinyi to Sixian显示文摘 | Yao Daquan Liu Jiacan Li Jie | 2003 | North China Earthquake Science2003，21，2： | 1 |
| 12 | Microscopic Indicators of Stick-Slip and Creep-Slip in Deformation Products From the Daqingshan Piedmont Active Fault显示文摘Through the collection of oriented samples,consolidation of undisturbed samples,and systematic microscopy of thin sections,the deformation products from the Daqingshan piedmont active fault zone have been studied.The obtained results have been analyzed in combination with those of rock fracture experiments and macroscopic surveys.Based on the above,the present article summarizes the microscopic indicators of stick-slip and creep-slip,which reflect the characteristics of fault movement,and has given some suggestion on relevant problems. | Yao Daquan,Tang Youbiao,Li Jie,and Liu JiacanSeismological Bureau of Anhui Province,Hefei 230031,China | 1996 | Earthquake Research in China1996，10，1： | 1 |
| 13 | CD47KO/CRT dual-bioengineered cell membrane-coated nanovaccine combined with anti-PD-L1 antibody for boosting tumor immunotherapy显示文摘Tumor vaccines trigger tumor-specific immune responses to prevent or treat tumors by activating the hosts’immune systems,and therefore,these vaccines have potential clinical applications.However,the low immunogenicity of the tumor antigen itself and the low efficiency of the vaccine delivery system hinder the efficacy of tumor vaccines that cannot produce high-efficiency and long-lasting antitumor immune effects.Here,we constructed a nanovaccine by integrating CD47KO/CRT dual-bioengineered B16F10 cancer cell membranes and the unmethylated cytosine-phosphate-guanine(CpG)adjuvant.Hyperbranched PEI25k was used to load unmethylated cytosine-phosphate-guanine(CpG)through electrostatic adsorption to prepare PEI25k/CpG nanoparticles(PEI25k/CpG-NPs).CD47KO/CRT dual-bioengineered cells were obtained by CRISPR-Cas9 gene editing technology,followed by the cell surface translocation of calreticulin(CRT)to induce immunogenic cell death(ICD)in vitro.Finally,the extracted cell membranes were coextruded with PEI25k/CpG-NPs to construct the CD47KO/CRT dual-bioengineered cancer cell membrane-coated nanoparticles(DBE@CCNPs).DBE@CCNPs could promote endocytosis of antigens and adjuvants in murine bone marrow derived dendritic cells(BMDCs)and induce their maturation and antigen cross-presentation.To avoid immune checkpoint molecule-induced T cell dysfunction,the immune checkpoint inhibitor,the anti-PD-L1 antibody,was introduced to boost tumor immunotherapy through a combination with the DBE@CCNPs nanovaccine.This combination therapy strategy can significantly alleviate tumor growth and may open up a potential strategy for clinical tumor immunotherapy. | Shengyang Liu Jiayan Wu Yuanji Feng Xiaoya Guo Tong Li Meng Meng Jie Chen Daquan Chen Huayu Tian | 2023 | Bioactive Materials2023，，4： | 0 |
| 14 | Top-down method to fabricate TiNi_(1+x)Sn half-Heusler alloy with high thermoelectric performance显示文摘The top-down method was used to fabricate the TiNi_(1+x)Sn half-Heusler alloy.Several knotty problems have been solved using the top-down method,including the generation of impurity phases,the visible discrepancy in the grain size of the TiNi_(2)Sn second phase,and irregular variations in the Seebeck coefficient(S),electrical conductivity(σ),and thermal conductivity(κ)with increasing Ni content.The generation of a large number of incoherent interfaces between the half-Heusler(HH)and full-Heusler(FH)phases fabricated by the top-down method drastically improved and retained κ and S,thereby leading to an enhancement in the dimensionless figure of merit(ZT)by~19%for the TiNi_(1.05)Sn sample as compared to the ZT of the samples prepared by the conventional method. | Xiong Yang Daquan Liu Jianbo Li Ruonan Min Huijun Kang Li Linwei Zongning Chen Enyu Guo Tongmin Wang | 2021 | Journal of Materials Science & Technology2021，，28： | 0 |
| 15 | Elementary Research on Activity Behavior of the Crust in Funan-Huoqiu Area, Southern Border of the North China Active Block Region显示文摘The Funan-Huoqiu area is located in the border tectonic belt between the North China and South China active block regions. By means of seismological and geological surveys and synthetic analysis, evidences of tectonic deformation in lower intensity have been found in the area since Late Pleistocene, where small earthquakes are distributed linearly along the main faults, conjugate shear joints are developed in the Upper Pleistocene nearby the faults. In the south of the studied region, fissures with different lengths, widths and directions occurred successively in Gushi, Huoqiu, Funan and other places of the area, in the 1970’s, and the direction of the fissures is approximately consistent with that of the Feizhong fault and Wanglaorenji fault. The authors hold that the clustering of small earthquakes, the conjugate shear joints developed in the Upper Pleistocene, the crumpled deformation of materials on fault plane, and the development of modern surface fissures in the area all reflect that the energy in the crust was slowly released, and that the weak deformation took place in corresponding faults. There was only one destructive earthquake taking place in the area (the Jiangkouji {M_S43/4} earthquake). Altogather, there has been weak activity in the area since the Late Quaternary, and it is mainly shown as a creep-slip. | Yao Daquan Liu Jiacan | 2005 | Earthquake Research in China2005，19，4： | 0 |
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