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您的检索式：作者名="Danqi Feng"
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| 1 | Polarization evolution dynamics of dissipative soliton fiber lasers显示文摘Dissipative solitons emerge as stable pulse solutions of nonintegrable and nonconservative nonlinear physical systems, owing to a balance of nonlinearity, dispersion, and loss/gain. A considerable research effort has been dedicated to characterizing amplitude and phase evolutions in the spatiotemporal dynamics of dissipative solitons emerging from fiber lasers. Yet, the picture of the buildup process of dissipative solitons in fiber lasers is incomplete in the absence of corresponding information about the polarization evolution. Here, we characterize probabilistic polarization distributions in the buildup of dissipative solitons in a net-normal dispersion fiber laser system, mode-locked by single-wall carbon nanotubes. The output optical spectra under different pump powers are filtered by a tunable filter, and are detected by a polarization state analyzer. The laser system operates from random amplified spontaneous emission into a stable dissipative soliton state as the cavity gain is progressively increased. Correspondingly, the state of polarization of each spectral wavelength converges towards a fixed point.To reveal the invariant polarization relationship among the various wavelength components of the laser output field, the phase diagram of the ellipticity angle and the spherical orientation angle is introduced. We find that,within the central spectral region of the dissipative soliton, the state of polarization evolves with frequency by tracing a uniform arc on the Poincaré sphere, whereas in the edges of the dissipative soliton spectrum, the state of polarization abruptly changes its path. Increasing cavity gain leads to spectral broadening, accompanied by a random scattering of the state of polarization of newly generated frequencies. Further increases of pump power result in dissipative soliton explosions, accompanied by the emergence of a new type of optical polarization rogue waves. These experimental results provide a deeper insight into the transient dynamics of dissipative soliton fiber lasers. | Lei Gao Yulong Cao Stefan Wabnitz Hongqing Ran Lingdi Kong Yujia Li Wei Huang Ligang Huang Danqi Feng Tao Zhu | 2019 | Photonics Research2019，7，11： | 1 |
| 2 | Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma显示文摘Objective:Pancreatic ductal adenocarcinoma(PDAC)is a highly malignant gastrointestinal cancer with a 5-year survival rate of only 9%.Of PDAC patients,15%-20%are eligible for radical surgery.Gemcitabine is an important chemotherapeutic agent for patients with PDAC;however,the efficacy of gemcitabine is limited due to resistance.Therefore,reducing gemcitabine resistance is essential for improving survival of patients with PDAC.Identifying the key target that determines gemcitabine resistance in PDAC and reversing gemcitabine resistance using target inhibitors in combination with gemcitabine are crucial steps in the quest to improve survival prognosis in patients with PDAC.Methods:We constructed a human genome-wide CRISPRa/dCas 9 overexpression library in PDAC cell lines to screen key targets of drug resistance based on sgRNA abundance and enrichment.Then,co-IP,ChIP,ChIP-seq,transcriptome sequencing,and qPCR were used to determine the specific mechanism by which phospholipase D1(PLD1)confers resistance to gemcitabine.Results:PLD1 combines with nucleophosmin 1(NPM1)and triggers NPM1 nuclear translocation,where NPM1 acts as a transcription factor to upregulate interleukin 7 receptor(IL7R)expression.Upon interleukin 7(IL-7)binding,IL7R activates the JAK1/STAT5 signaling pathway to increase the expression of the anti-apoptotic protein,BCL-2,and induce gemcitabine resistance.The PLD1 inhibitor,Vu0155069,targets PLD1 to induce apoptosis in gemcitabine-resistant PDAC cells.Conclusions:PLD1 is an enzyme that has a critical role in PDAC-associated gemcitabine resistance through a non-enzymatic interaction with NPM1,further promoting the downstream JAK1/STAT5/Bcl-2 pathway.Inhibiting any of the participants of this pathway can increase gemcitabine sensitivity. | Danqi Fu Jingrui Yan Zhaoyu Zhang Yang Liu Xiaoqing Ma Jinsheng Ding Shengyu Yang Ran Zhao Antao Chang Chuntao Gao Jing Liu Tiansuo Zhao Xiuchao Wang Chongbiao Huang Song Gao Ying Ma Bo Tang Yukuan Feng Hongwei Wang Jihui Hao | 2023 | Cancer Biology & Medicine2023，20，8： | 0 |
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