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| 1 | Extensively drug-resistant bacteria are an independent predictive factor of mortality in 130 patients with spontaneous bacterial peritonitis or spontaneous bacteremia显示文摘AIM: To evaluate the epidemiology and outcomes of culture-positive spontaneous bacterial peritonitis(SBP) and spontaneous bacteremia(SB) in decompensated cirrhosis.METHODS: We prospectively collected clinical, laboratory characteristics, type of administered antibiotic, susceptibility and resistance of bacteria to antibiotics in one hundred thirty cases(68.5% males) with positive ascitic fluid and/or blood cultures during the period from January 1, 2012 to May 30, 2014. All patients with SBP had polymorphonuclear cell count in ascitic fluid > 250/mm3. In patients with SB a thorough study did not reveal any other cause of bacteremia. The patients were followed-up for a 30-d periodfollowing diagnosis of the infection. The final outcome of the patients was recorded in the end of follow-up and comparison among 3 groups of patients according to the pattern of drug resistance was performed.RESULTS: Gram-positive-cocci(GPC) were found in half of the cases. The most prevalent organisms in a descending order were Escherichia coli(33), Enterococcus spp(30), Streptococcus spp(25), Klebsiella pneumonia(16), S. aureus(8), Pseudomanas aeruginosa(5), other Gram-negative-bacteria(GNB)(11) and anaerobes(2). Overall, 20.8% of isolates were multidrug-resistant(MDR) and 10% extensively drugresistant(XDR). Health-care-associated(HCA) and/or nosocomial infections were present in 100% of MDR/XDR and in 65.5% of non-DR cases. Meropenem was the empirically prescribed antibiotic in HCA/nosocomial infections showing a drug-resistance rate of 30.7% while third generation cephalosporins of 43.8%. Meropenem was ineffective on both XDR bacteria and Enterococcus faecium(E. faecium). All but one XDR were susceptible to colistin while all GPC(including E. faecium) and the 86% of GNB to tigecycline. Overall 30-d mortality was 37.7%(69.2% for XDR and 34.2% for the rest of the patients)(log rank, P = 0.015). In multivariate analysis, factors adversely affecting outcome included XDR infection(HR = 2.263, 95%CI: 1.005-5.095, P = 0.049), creatinine(HR = 1.125, 95%CI: 1.024-1.236, P = 0.015) and INR(HR =1.553, 95%CI: 1.106-2.180, P = 0.011).CONCLUSION: XDR bacteria are an independent lifethreatening factor in SBP/SB. Strategies aiming at restricting antibiotic overuse and rapid identification of the responsible bacteria could help improve survival. | Alexandra Alexopoulou Larisa Vasilieva Danai Agiasotelli Kyriaki Siranidi Sophia Pouriki Athanasia Tsiriga Marina Toutouza Spyridon P Dourakis | 2016 | World Journal of Gastroenterology2016，22，15： | 19 |
| 2 | Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer显示文摘AIM To investigate the impact of thymidylate synthase(TYMS), KRAS and BRAF in the survival of metastatic colorectal cancer(m CRC) patients treated with chemotherapy. METHODS Clinical data were collected retrospectively from records of consecutive patients with m CRC treated with fluoropyrimidine-based chemotherapy from 1/2005 to 1/2007. Formalin-fixed paraffin-embedded tissues were retrieved for analysis. TYMS genotypes were identified with restriction fragment analysis PCR, while KRAS and BRAF mutation status was evaluated using real-time PCR assays. TYMS gene polymorphisms of each of the 3' untranslated region(UTR) and 5'UTR were classified into three groups according to the probability they have for high, medium and low TYMS expression(and similar levels of risk) based on evidence from previous studies. Univariate and multivariate survival analyses were performed.RESULTS The analysis recovered 89 patients with m CRC(46.1% de novo metastatic disease and 53.9% relapsed). Of these, 46 patients(51.7%) had colon cancer and 43(48.3%) rectal cancer as primary. All patients were treated with fluoropyrimidine-based chemotherapy(5FU or capecitabine) as single-agent or in combination with irinotecan or/and oxaliplatin or/and bevacizumab. With a median follow-up time of 14.8 mo(range 0-119.8), 85 patients(95.5%) experienced disease progression, and 63 deaths(70.8%) were recorded. The 3-year and 5-year OS rate was 25.4% and 7.7% while the 3-year progression-free survival rate was 7.1%. Multivariate analysis of TYMS polymorphisms, KRAS and BRAF with clinicopathological parameters indicated that TYMS 3'UTR polymorphisms are associated with risk for disease progression and death(P < 0.05 and P < 0.03 respectively). When compared to tumors without any del allele(genotypes ins/ins and ins/loss of heterozygosity(LOH) linked with high TYMS expression) tumors with del/del genotype(low expression group) and tumors with ins/del or del/LOH(intermediate expression group) have lower risk for disease progression(HR = 0.432, 95%CI: 0.198-0.946, P < 0.04 and HR = 0.513, 95%CI: 0.287-0.919, P < 0.03 respectively) and death(HR = 0.366, 95%CI: 0.162-0.827, P < 0.02 and HR = 0.559, 95%CI: 0.309-1.113, P < 0.06 respectively). Additionally,KRAS mutation was associated independently with the risk of disease progression(HR = 1.600, 95%CI: 1.011-2.531, P < 0.05). The addition of irinotecan in 1st line chemotherapy was associated independently with lower risk for disease progression and death(HR = 0.600, 95%CI: 0.372-0.969, P < 0.04 and HR = 0.352, 95%CI: 0.164-0.757, P < 0.01 respectively).CONCLUSION The TYMS genotypes ins/ins and ins/LOH associate with worst prognosis in m CRC patients under fluoropyrimidine-based chemotherapy. Large prospective studies are needed for validation of our findings. | Anastasios Ntavatzikos Aris Spathis Paul Patapis Nikolaos Machairas George Peros Stefanos Konstantoudakis Danai Leventakou Ioannis G Panayiotides Petros Karakitsos Anna Koumarianou | 2017 | World Journal of Gastroenterology2017，23，32： | 4 |
| 3 | Accurate charac- terization of extravascular lung water in acute respiratory dis- tress syndrome 显示文摘 | Berkowitz DM Danai PA Eaton S | 2008 | Crit Care Med2008，36，6： | 1 |
| 4 | 3D Measurement of Micromechanical Devices Vibration Mode Shapes with a Stroboscopic Interferometric Microscope显示文摘 | PETITGRAND S YAHIAOUI R DANAIE K | 2001 | Optics and Lasers in Engineering2001，36，2： | 1 |
| 5 | Accurate characteriza- tion of extravascular lung water in acute respiratory distress syn- drome显示文摘 | Berkowitz D M Danai P A Eaton S | 2008 | Crit Care Med2008，36，6： | 1 |
| 6 | Vancomycin-resistant Enterococcus outbreak in a neonatal intensive care unit: Epidemiology, molecular analysis and risk factors显示文摘 | Elias Iosifidis Ioanna Evdoridou Eleni Agakidou Elpis Chochliourou Efthimia Protonotariou Konstantina Karakoula Ioannis Stathis Danai Sofianou Vassiliki Drossou-Agakidou Spyros Pournaras Emmanuel Roilides | 2013 | AJIC: American Journal of Infection Control2013，，： | 1 |
| 7 | Accurate characterization of extravascular lung water in acute respiratory distress syndrome显示文摘 | Berkowitz DM Danai PA Eaton S | 2008 | Crit Care Med2008，36，6： | 1 |
| 8 | In vivo selective gene expression and therapy mesiated by adenoviral vecters for hunan carcinoembryonic antigen-prdducing gastric carcinoma 显示文摘 | Lan KH Danai F Shiratofi Y | 1997 | Cancer Res1997，57，19： | 1 |
| 9 | The epidemiology of sep-sis in patient with malignancy显示文摘 | Danai P A Moss M Mannino D M | 2006 | Chest2006，129，： | 1 |
| 10 | Accurate characterization of extravascular lung water in acute respiratory distress syndrome显示文摘 | David M. Berkowitz Pajman A. Danai Stephanie Eaton Marc Moss Greg S. Martin | 2008 | Critical Care Medicine2008，，6： | 1 |
| 11 | Bulk Treatment of Substrate for the Cultivation of Shiitake Mushrooms (Lentinus edodes) on Straw显示文摘 | LEVANON D ROTHSCHILD N DANAI O | 1993 | Bioresource Technology1993，45，1： | 1 |
| 12 | Laboratory Measurements and Models of Modern Loads and Their Effect on Voltage Stability 显示文摘 | HAJAGOS L M DANAI B | 1998 | IEEE Transactions on Power System1998，13，2： | 1 |
| 13 | Accurate characterization Of extravascular lung water in acute respiratory distress syndrom 显示文摘 | Berkowitz DM Danai PA Eaton S | 2008 | Crit Care Med2008，36，6： | 1 |
| 14 | Adaptive method of helicopter track and balance 显示文摘 | Wang Shengda Danai Kourosh Wilson Mark | 2005 | Journal of Dynamic Systems Measurement and Control2005，127，6： | 1 |
| 15 | Primary Ovarian Non-Hodgkin’s Lymphoma: Outcome after Treatment with Combination Chemotherapy显示文摘 | Meletios A. Dimopoulos Danai Daliani William Pugh David Gershenson Fernando Cabanillas Andreas H. Sarris | 1997 | Gynecologic Oncology1997，，3： | 1 |
| 16 | Accurate c- haracterization of extravascular lung water in acute res- piratory distress syndrome显示文摘 | Berkowltz DM Danai PA Eaton S | 2008 | Crit Care Med2008，36，6： | 1 |
| 17 | Fibrinolysis for patients with intermedi- ate-risk pulmonary embolism 显示文摘 | Meyer G Vicaut E Danays T | 2014 | N Engl J Med2014，370，15： | 1 |
| 18 | Interatrial block: is it time for more attention?显示文摘 | Danai Kitkungvan David H. Spodick | 2009 | Journal of Electrocardiology2009，，6： | 1 |
| 19 | Level ofOpisthorchis infestation and carcinogen dose-dependence of cholangiocarcinoma induction in Syrian golden hamsters显示文摘 | Witaya Thamavit Rungtiva Kongkanuntn Danai Tiwawech Malcolm Anthony Moore | 1987 | Virchows Archiv B Cell Pathology Including Molecular Pathology1987，，1： | 1 |
| 20 | Seasonal variation in the epidemiology of sepsis显示文摘 | Danai PA Sinha S Moss M | 2007 | Crit Care Med2007，35，2： | 1 |
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