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| 1 | The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration显示文摘The endosomal-lysosomal system is made up of a set of intracellular membranous compartments that dynamically interconvert,which is comprised of early endosomes,recycling endosomes,late endosomes,and the lysosome.In addition,autophagosomes execute autophagy,which delivers intracellular contents to the lysosome.Maturation of endosomes and/or autophagosomes into a lysosome creates an unique acidic environment within the cell for proteolysis and recycling of unneeded cellular components into usable amino acids and other biomolecular building blocks.In the endocytic pathway,gradual maturation of endosomes into a lysosome and acidification of the late endosome are accompanied by vesicle trafficking,protein sorting and targeted degradation of some sorted cargo.Two opposing sorting systems are operating in these processes:the endosomal sorting complex required for transport(ESCRT)supports targeted degradation and the retromer supports retrograde retrieval of certain cargo.The endosomal-lysosomal system is emerging as a central player in a host of neurodegenerative diseases,demonstrating potential roles which are likely to be revealed in pathogenesis and for viable therapeutic strategies.Here we focus on the physiological process of endosomal-lysosomal maturation,acidification and sorting systems along the endocytic pathway,and further discuss relationships between abnormalities in the endosomal-lysosomal system and neurodegenerative diseases,especially Alzheimer’s disease(AD). | Yong-Bo Hu Eric B Dammer Ru-Jing Ren Gang Wang | 2015 | Translational Neurodegeneration2015，4，1： | 4 |
| 2 | Coregulator exchange and sphingosinesensitive eooperativity of steroidogenic factor-1, general control nonderepressed5 ,p54 ,and p160 coaetivators regulate cyclic adenosine 3, 5-monophosphatedependent cytochromeP450e17 transcription rate 显示文摘 | Dammer E B Leon A Sewer M B | 2007 | Mol Endocrinol2007，，： | 1 |
| 3 | Endovascular coil occlusion of intracranial aneurysms assisted by a novel self-expand- able nitinol mierostent (neuroform)显示文摘 | Henkes H Bose A Felber S Miloslavski E Berg- Dammer E Kuhne D | 2002 | Interv Neuro- radiol2002，8，： | 1 |
| 4 | Connexin43 expression and distribution in compensated and decompensated cardiac hypertrophy in patients with aortic stennsis显示文摘 | Kostin S Dammer S Hein S | 2004 | Cardiovasc Res2004，62，2： | 1 |
| 5 | Conservative or radical treatment of keratocysts: a retrospective review显示文摘 | Dammer R Niederdellmann H Dammer P | 1997 | Br J Oral Maxillofac Surg1997，35，1： | 1 |
| 6 | Risk factors for infections related to external ventricular drainage 显示文摘 | Hoefnagel D Dammers R Ter Laak-Poort MP | 2008 | Acta Neurochir (Wien)2008，150，3： | 1 |
| 7 | Lumbar disc herniation:level increase with age显示文摘 | Dammers R Koehler PJ | 2002 | Surg Neurol2002，58，34： | 1 |
| 8 | Risk fac- tors for infections related to external ventricular drainage显示文摘 | Hoefnagel D Dammers R Ter Laak-Poort M P | 2008 | Acta Neurochir (Wien)2008，150，3： | 1 |
| 9 | Signal enhancement in polarized light imaging by means of independent component analysis显示文摘 | DAMMERS J AXER M GRASSEL D | 2010 | Neuroimage2010，49，2： | 1 |
| 10 | Effect of the C825T polymorphism of the G protein beta 3 subunit on the systolic blood pressure lowering effect of clonidine in young, healthy male subjects 显示文摘 | Nurnberger J Dammer S Mitchell A | 2003 | Clin Pharmacol Ther2003，74，： | 1 |
| 11 | Lumbar disc herniation: level increases with age显示文摘 | Dammers tL Koehler PJ | 2002 | Surg Neurol2002，58，34： | 1 |
| 12 | Risk factors for infections related to external ventrioular drainage显示文摘 | D Hoefnagel R Dammers MP Ter Laak-Poort et aJ | 2013 | Acta Neurochirurgi ca2013，13，3： | 1 |
| 13 | Using real patients in problem- based learning: students comments on the value of using real, as op- posed to paper cases, in a problem-based learning module in general practice显示文摘 | Dammers J Spencer J Thomas M | 2001 | Med Educ2001，35，1： | 1 |
| 14 | Using real patients in problem-based learning: students' comments on thevalue of using real, as opposed to paper, cases in a problem-based learning module in general practice显示文摘 | Dammers J Spencer J Thomas M | 2001 | Med Educ2001，35，： | 1 |
| 15 | Safety and efficacy of frarneless and frame-based intracranial biopsy techniques 显示文摘 | Dammers R Haitsma IK Schouten JW | 2008 | Acta Neurochir (Wien)2008，150，1： | 1 |
| 16 | Using real patients in problem-based learning:students 'comments on the value of using real,as opposed to paper cases,in a problem-based learning module in general practice显示文摘 | Jane Dammers John Spencer Malcolm Thomas | 2001 | Medical Education2001，，35： | 1 |
| 17 | Effects of heterogeneity on diffusion in nanopores—From inorganic materials to protein crystals and ion channels显示文摘 | Marc-Olivier Coppens Anton J. Dammers | 2006 | Fluid Phase Equilibria2006，，1： | 1 |
| 18 | Using real patients in problem- based learning: students' comments on the value of using real, as opposed to paper cases, in a problem-based learning module in general praetiee显示文摘 | Dammers J Spencer J Thomas M | 2001 | Med Edue2001，35，1： | 1 |
| 19 | Phase contrast enhanced high resolution X-ray imaging and tomography of soft tissue显示文摘 | Jakubek J Granja C Dammer J | | 0，，： | 1 |
| 20 | Supersta- bility of surface nanobubbles 显示文摘 | Borkent B M Dammer S M Schonherr H | 2007 | Phys Rev Lett2007，98，20： | 1 |
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