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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | Dismicrobism in inflammatory bowel disease and colorectal cancer: Changes in response of colocytes显示文摘Patients with inflammatory bowel disease(IBD)have an increased risk of 10%-15%developing colorectal cancer(CRC)that is a common disease of high economic costs in developed countries.The CRC has been increasing in recent years and its mortality rates are very high.Multiple biological and biochemical factors are responsible for the onset and progression of this pathology.Moreover,it appears absolutely necessary to investigate the environmental factors favoring the onset of CRC and the promotion of colonic health.The gut microflora,or microbiota,has an extensive diversity both quantitatively and qualitatively.In utero,the intestine of the mammalian fetus is sterile.At birth,the intestinal microbiota is acquired by ingesting maternal anal or vaginal organisms,ultimately developing into a stable community,with marked variations in microbial composition between individuals.The development of IBD is often associated with qualitative and quantitative disorders of the intestinal microbial flora(dysbiosis).The healthy human gut harbours about10 different bacterial species distributed in colony forming units which colonize the gastrointestinal tract.The intestinal microbiota plays a fundamental role in health and in the progression of diseases such as IBD and CRC.In healthy subjects,the main control of intestinal bacterial colonization occurs through gastric acidity but other factors such as endoluminal temperature,competition between different bacterial strains,peristalsis and drugs can influence the intestinal microenvironment.The microbiota exerts diverse physiological functions to include:growth inhibition of pathogenic microorganisms,synthesis of compounds useful for the trophism of colonic mucosa,regulation of intestinal lymphoid tissue and synthesis of amino acids.Furthermore,mucus seems to play an important role in protecting the intestinal mucosa and maintaining its integrity.Changes in the microbiota composition are mainly influenced by diet and age,as well as genetic factors.Increasing evidence indicates that dysbiosis favors the production of genotoxins and metabolites associated with carcinogenesis and induces dysregulation of the immune response whichpromotes and sustains inflammation in IBD leading to carcinogenesis.A disequilibrium in gut microflora composition leads to the specific activation of gut associated lymphoid tissue.The associated chronic inflammatory process associated increases the risk of developing CRC.Ulcerative colitis and Crohn’s disease are the two major IBDs characterized by an early onset and extraintestinal manifestations,such as rheumatoid arthritis.The pathogenesis of both diseases is complex and not yet fully known.However,it is widely accepted that an inappropriate immune response to microbial flora can play a pivotal role in IBD pathogenesis. | Giovanni Tomasello Pietro Tralongo Provvidenza Damiani Emanuele Sinagra Benedetto Di Trapani Marie Noelle Zeenny Inaya Hajj Hussein Abdo Jurjus Angelo Leone | 2014 | World Journal of Gastroenterology2014，20，48： | 10 |
| 3 | Eye reflux:an ocular extraesophageal manifestation of gastric reflux显示文摘AIM: To suspect laryngopharyngeal reflux(LPR) in patients with ocular surface disease(OSD). METHODS: The present study evaluated a group of subjects with OSD assessing the Ocular Surface Disease Index(OSDI) and the Reflux Symptom Index(RSI) to detect patients with suspected LPR and define a possible relationship between tests.RESULTS: Two hundred and ninety subjects(175 females, mean age: 60.41±15.68y) were consecutively visited at ophthalmologist offices. One hundred and one(34%) patients had pathological RSI(>13) and consequently a suspected LPR.CONCLUSION: The current study shows that suspected LPR may be common(34%) in patients with OSD and a suspected LPR may be considered in OSD patients when RSI score is >13 and OSDI score is >42. | Danilo Mazzacane Valerio Damiani Michela Silvestri Giorgio Ciprandi Pierfranco Marino | 2018 | International Journal of Ophthalmology(English edition)2018，11，9： | 2 |
| 4 | Breast tumor resembling the tall cell variant of papillary thyroid carcinoma: report of 5 cases 显示文摘 | Eusebi V Damiani S Ellis IO | 2003 | Am J Surg pathol2003，27，8： | 1 |
| 5 | Laparoscopic myomectomy for very large myomas using an isobaric (gasless) technique 显示文摘 | Damiani A Melgrati L Marziali M | 2005 | JSLS2005，9，4： | 1 |
| 6 | Treatment of inferior turbinate hypertrophy:a randomized clinical trial显示文摘 | Passali D Passali FM Damiani V | 2003 | Ann Otol Rhinol Laryngol2003，112，8： | 1 |
| 7 | Managing and sharing servents' reputations in P2P systems显示文摘 | DAMIANI E DE CAPITANI DI VIMERCATI S PARABOSCHI S SAMARATI P | 2003 | IEEE Transactions on Data and Knowledge Engineering2003，15，4： | 1 |
| 8 | Prebubertal calves as oocyte donors: promises and problems 显示文摘 | Duby RT Damiani P Looney CR | 1996 | Theriogenology1996，45，： | 1 |
| 9 | P-glycoprotein,lung resistance-related protein and multidrugresistance-associated protein in de novo adult acute lymphoblastic leukemia显示文摘 | Damiani D Michelutti A Michieli M | 2002 | Br J Haematol2002，116，3： | 1 |
| 10 | Laser conditioning of KDP crystals using excimer and Nd:YAG lasers显示文摘 | Bertussi B Damiani D Pommies M | | 0，，： | 1 |
| 11 | Does HE4 have a role as biomarker in the recurrence of ovarian cancer?显示文摘 | Francesco Plotti Stella Capriglione Corrado Terranova Roberto Montera Alessia Aloisi Patrizio Damiani Ludovico Muzii Giuseppe Scaletta Pierluigi Benedetti-Panici Roberto Angioli | 2012 | Tumor Biology2012，，： | 1 |
| 12 | Micromechanics of fabric reinfored composites with periodic microstructure显示文摘 | BARBERO E J DAMIANI T M ROVILLION J T | 2005 | International Journal of Solids and Structures2005，42，910： | 1 |
| 13 | Design and Implementation of an Access Control Processor for XML Documents显示文摘 | DAMIANI E VIMERCATI S PARABOSCHI S | 2000 | Computer Networks2000，33，16： | 1 |
| 14 | Treatment of inferior turbinate hypertrophy:a randomized clinical trial显示文摘 | Passali D Passali FM Damiani V | 2003 | AnnOtol RhinolLaryngol2003，112，8： | 1 |
| 15 | UV-Fiher combinations under UV-A exposure : concomitant quantification of overall spectral stability and molecular integrity 显示文摘 | DAMIANI E BASCHONG W GRECI L | 2007 | Journal of Photochemistry and Photobiology B : Biology2007，87，2： | 1 |
| 16 | Excimer laser conditioning of KDP:influence of the laser parameters and crystal orientation on the laser damage threshold显示文摘 | Damiani D Piombini H Plessis D | | 0，，： | 1 |
| 17 | Isobaric(gasless) laparoscopic myomectomy during pregnancy显示文摘 | Melgrati L Damiani A Franzoni G | | 0，，04： | 1 |
| 18 | Carcinogen- induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells 显示文摘 | Damiani L A Yingling C M Leng S | 2008 | Cancer Research2008，68，21： | 1 |
| 19 | Spontaneous extracranial carotid atherosclerosis evolution in asymptomatic individuals:A three-year prospective study显示文摘 | Gagliardi RJ Damiani IT Menoncello R | 2004 | Arq Neuropsiquiatr2004，62，： | 1 |
| 20 | Isobaric (gasless) laparoscopic myomectomy during pregnancy 显示文摘 | Melgrati L Damiani A Franzoni G | 2005 | J Minim Invasive Gynecol2005，12，4： | 1 |
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