| 2 | RNA editing enzyme ADAR1 is required for early T cell development显示文摘The RNA editing enzyme ADAR1 has been shown to be an essential molecule for hematopoietic cell differentiation,embryonic development,and regulation of immune responses.Here,we present evidence in a T-cell-specific gene knockout mouse model that ADAR1 is required for early T cell development.Loss of ADAR1 led to cell death of the progenitors at the double negative stage and prevented T cell maturation in the thymus.Furthermore,ADAR1 deletion in pre-T cells preferentially affected TCRb-expressing cells causing TCRb positive cell depletion.Interruption of IFN signaling occurred in the premature T cells,indicating a role of IFN signaling in the survival of TCRb-expressing cells regulated by ADAR1.This study demonstrated an essential role for the RNA editing enzyme ADAR1 as a potential regulator for T-cell fate determination during clonal selection,which,in turn,contributes to immunologic homeostasis. | Richard Xufeng Daibang Nie Qiong Yang Wang Wang Tao Cheng Qingde Wang | 2020 | Blood Science2020，2，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员