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| 1 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 2 | Nickel-exposed Workers in China: A Cohort Study显示文摘There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a | BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying | 2014 | Biomedical and Environmental Sciences2014，27，3： | 20 |
| 3 | Assessing the effects of vegetation and precipitation on soil erosion in the Three-River Headwaters Region of the Qinghai-Tibet Plateau,China显示文摘Soil erosion in the Three-River Headwaters Region(TRHR)of the Qinghai-Tibet Plateau in China has a significant impact on local economic development and ecological environment.Vegetation and precipitation are considered to be the main factors for the variation in soil erosion.However,it is a big challenge to analyze the impacts of precipitation and vegetation respectively as well as their combined effects on soil erosion from the pixel scale.To assess the influences of vegetation and precipitation on the variation of soil erosion from 2005 to 2015,we employed the Revised Universal Soil Loss Equation(RUSLE)model to evaluate soil erosion in the TRHR,and then developed a method using the Logarithmic Mean Divisia Index model(LMDI)which can exponentially decompose the influencing factors,to calculate the contribution values of the vegetation cover factor(C factor)and the rainfall erosivity factor(R factor)to the variation of soil erosion from the pixel scale.In general,soil erosion in the TRHR was alleviated from 2005 to 2015,of which about 54.95%of the area where soil erosion decreased was caused by the combined effects of the C factor and the R factor,and 41.31%was caused by the change in the R factor.There were relatively few areas with increased soil erosion modulus,of which 64.10%of the area where soil erosion increased was caused by the change in the C factor,and 23.88%was caused by the combined effects of the C factor and the R factor.Therefore,the combined effects of the C factor and the R factor were regarded as the main driving force for the decrease of soil erosion,while the C factor was the dominant factor for the increase of soil erosion.The area with decreased soil erosion caused by the C factor(12.10×10^3 km^2)was larger than the area with increased soil erosion caused by the C factor(8.30×10^3 km^2),which indicated that vegetation had a positive effect on soil erosion.This study generally put forward a new method for quantitative assessment of the impacts of the influencing factors on soil erosion,and also provided a scientific basis for the regional control of soil erosion. | HE Qian DAI Xiao'ai CHEN Shiqi | 2020 | Journal of Arid Land2020，12，5： | 9 |
| 4 | Involvement of phosphatase and tensin homolog-induced putative kinase 1–Parkin-mediated mitophagy in septic acute kidney injury显示文摘Background:Studies have reported mitophagy activation in renal tubular epithelial cells(RTECs)in acute kidney injury(AKI).Phosphatase and tensin homolog-induced putative kinase 1(PINK1)and E3 ubiquitin-protein ligase Parkin are involved in mitophagy regulation;however,little is known about the role of PINK1-Parkin mitophagy in septic AKI.Here we investigated whether the PINK1-Parkin mitophagy pathway is involved in septic AKI and its effects on cell apoptosis in vitro and on renal functions in vivo.Methods:Mitophagy-related gene expression was determined using Western blot assay in human RTEC cell line HK-2 stimulated with bacterial lipopolysaccharide(LPS)and in RTECs from septic AKI rats induced by cecal ligation and perforation(CLP).Autophagy-related ultrastructural features in rat RTECs were observed using electron microscopy.Gain-and loss-of-function approaches were performed to investigate the role of the PINK1-Parkin pathway in HK-2 cell mitophagy.Autophagy activators and inhibitors were used to assess the effects of mitophagy modulation on cell apoptosis in vitro and on renal functions in vivo.Results:LPS stimulation could significantly induce LC3-II and BECN-1 protein expression(LC3-II:1.72±0.05 vs.1.00±0.05,P<0.05;BECN-1:5.33±0.57 vs.1.00±0.14,P<0.05)at 4 h in vitro.Similarly,LC3-II,and BECN-1 protein levels were significantly increased and peaked at 2 h after CLP(LC3-II:3.33±0.12 vs.1.03±0.15,P<0.05;BECN-1:1.57±0.26 vs.1.02±0.11,P<0.05)in vivo compared with those after sham operation.Mitochondrial deformation and mitolysosome-mediated mitochondria clearance were observed in RTECs from septic rats.PINK1 knockdown significantly attenuated LC3-II protein expression(1.35±0.21 vs.2.38±0.22,P<0.05),whereas PINK1 overexpression markedly enhanced LC3-II protein expression(2.07±0.21 vs.1.29±0.19,P<0.05)compared with LPS-stimulated HK-2 cells.LPS-induced proapoptotic protein expression remained unchanged in autophagy activator-treated HK-2 cells and was significantly attenuated in PINK1-overexpressing cells,but was remarkably upregulated in autophagy inhibitor-treated and in PINK1-depleted cells.Consistent results were observed in flow cytometric apoptosis assay and in renal function indicators in rats.Conclusion:PINK1-Parkin-mediated mitophagy might play a protective role in septic AKI,serving as a potential therapeutic target for septic AKI. | Xin-Gui Dai Wei Xu Tao Li Jia-Ying Lu Yang Yang Qiong Li Zhen-Hua Zeng Yu-Hang Ai | 2019 | Chinese Medical Journal2019，，19： | 9 |
| 5 | Composite solid electrolyte of Na3PS4-PEO for all-solid-state SnS2/Na batteries with excellent interfacial compatibility between electrolyte and Na metal显示文摘High ionic conductivity and superior interfacial stability of solid electrolytes at the electrodes are crucial factors for high-performance all-solid-state sodium batteries. Herein, a composite solid electrolyte Na3PS4-polyethylene oxide is synthesized by the solution-phase reaction method with an improved ionic conductivity up to 9.4 × 10-5 S/cm at room temperature. Moreover, polyethylene oxide polymer layer is wrapped homogeneously on the surface of Na3PS4 particles, which could effectively avoid the direct contact between Na3PS4 electrolyte and sodium metal, thus alleviate their side reactions. We demonstrate that all-solid-state battery SnS2/Na with the composite solid electrolyte Na3PS4-polyethylene oxide delivers an enhanced electrochemical performance with 230 m Ah/g after 40 cycles. | Xiaoyan Xu Yuanyuan Li Jun Cheng Guangmei Hou Xiangkun Nie Qing Ai Linna Dai Jinkui Feng Lijie Ci | 2020 | Journal of Energy Chemistry2020，29，2： | 7 |
| 6 | 3D Printing Hip Prostheses Offer Accurate Reconstruction,Stable Fixation,and Functional Recovery for Revision Total Hip Arthroplasty with Complex Acetabular Bone Defect显示文摘Complicated and large acetabular bone defects present the main challenges and difficulty in the revision of total hip arthroplasty(THA).This study aimed to explore the advantages of three-dimensional(3D)printing technology in the reconstruction of such acetabular bone defects.We retrospectively analyzed the prognosis of four severe bone defects around the acetabulum in three patients who were treated using 3D printing technology.Reconstruction of bone defect by conventional methods was difficult in these patients.In this endeavor,we used radiographic methods,related computer software such as Materialise's interactive medical image control system and Siemens NX software,and actual surgical experience to estimate defect volume,prosthesis stability,and installation accuracy,respectively.Moreover,a Harris hip score was obtained to evaluate limb function.It was found that bone defects could be adequately reconstructed using a 3D printing prosthesis,and its stability was reliable.The Harris hip score indicated a very good functional recovery in all three patients.In conclusion,3D printing technology had a good therapeutic effect on both complex and large bone defects in the revision of THA.It was able to achieve good curative effects in patients with large bone defects. | Yongqiang Hao Lei Wang Wenbo Jiang Wen Wu Songtao Ai Lu Shen Shuang Zhao Kerong Dai | 2020 | Engineering2020，6，11： | 4 |
| 7 | Fast neutron radiation inactivation of Bacillus subtilis:Absorbed dose determination显示文摘In this paper,fast neutron inactivation effects of Bacillus subtilis were investigated with fission fast neutrons from CFBR-Ⅱreactor of INPC(Institute of Nuclear Physics and Chemistry)and mono-energetic neutrons from the Van de Graaff accelerator at Peking University.The method for determining the absorbed dose in the Bacillus subtilis suspension contained in test tubes is introduced.The absorbed dose,on account of its dependence on the volume and the form of confined state,was determined by combined experiments and Monte Carlo method.Using the calculation results of absorbed dose,the fast neutron inactivation effects on Bacillus subtilis were studied.The survival rates and absorbed dose curve was constructed. | SONG Lingli ZHENG Chun AI Zihui LI Junjie DAI Shaofeng | 2011 | Nuclear Science and Techniques2011，22，3： | 3 |
| 8 | SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models显示文摘异常成纤维细胞生长因素受体(FGFR ) 激活越过恶意的一个多样的系列被发现,特别缺乏有效治疗的那些。SOMCL-085 是一个新奇 FGFR 主导的多目标 kinase 禁止者。这里,我们在 vitro 并且在 vivo 探索了 SOMCL-085 的指向 FGFR anticancer 活动。在屏蔽的 20 酷氨酸 kinases 的一块面板之中, SOMCL-085 potently 分别地禁止了 FGFR1, FGFR2 和 FGFR3 kinase 活动,与 1.8, 1.9 和 6.9 nmol/L 的 IC 50 价值。这混合物同时禁止了 angiogenesis kinases VEGFR 和 PDGFR,但是没有另外的 12 酷氨酸 kinases 上的明显的禁止的效果。在有测试的 FGFR 激活的不同机制的 3 根代表性的人的癌症房间线, SOMCL-085 (20-500 nmol/L ) dose-dependently 禁止了 FGFR1-3 phosphorylation 和他们的关键下游的受动器 PLC 和英皇家空军之阶级最低之兵的 phosphorylation。在 7 根 FGFR 异常人的癌症房间线,不管 FGFR 在激活上的机械学的复杂性, SOMCL-085 potently 由在 G 1/S 阶段逮捕房间禁止了驾驶 FGFR 的房间增长。在 放大FGFR1 的肺癌症房间线 H1581 异种皮移植老鼠和 放大FGFR2 的胃的癌症房间衬里 SNU16 异种皮移植老鼠, SOMCL-085 的口头的管理( 25 ,吗 50 mg ????????????????????????????????漠敬湡汯捩??儠?????畱湩硯污湩?? | Xi-fei JIANG Yang DAI Xia PENG Yan-yan SHEN Yi SU Man-man WEI Wei-ren LIU Zhen-bin DING Ao ZHANG Ying-hong SHI Jing AI | 2018 | Acta Pharmacologica Sinica2018，39，2： | 3 |
| 9 | Infection with severe fever with thrombocytopenia virus in healthy population:a cohort study in a high endemic region,China显示文摘Background: Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.Methods: A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.Results: Totally 886 individuals were recruited. The baseline seroprevalence that was tested before the epidemic season was 11.9% (70/587) for IgG and 6.8% (40/587) for NAb, which was increased to 13.4% (47/350) and 7.7% (27/350) during the epidemic season, and further to 15.8% (80/508) and 9.8% (50/508) post epidemic. The IgG antibody-based seropositivity was significantly related to the patients aged ≥ 70 years old [adjusted odds ratio (OR) = 2.440, 95% confidence interval (CI): 1.334-4.461 compared to the group of < 50 years old,P = 0.004], recent contact with cats (adjustedOR = 2.195, 95%CI: 1.261-3.818,P = 0.005), and working in tea garden (adjustedOR = 1.698, 95%CI: 1.002-2.880,P = 0.049) by applying multivariate logistic regression model. The NAb based seropositivity was similarly related to the patients aged ≥ 70 years old (adjustedOR = 2.691, 95%CI: 1.271-5.695 compared to the group of < 50 years old,P = 0.010), and recent contact with cats (OR = 2.648, 95%CI: 1.419-4.941,P = 0.002). For a cohort of individuals continually sampled with 1-year apart, the anti-SFTSV IgG were maintained at a stable level, while the NAb level reduced.Conclusions: Subclinical infection might not provide adequate immunity to protect reinfection of SFTSV, thus highlighting the ongoing threats of SFTS in endemic regions, which called for an imperative need for vaccine development. Identification of risk factors might help to target high-risk population for public health education and vaccination in the future. | Xiao‑Lei Ye Ke Dai Qing‑Bin Lu Yan‑Qin Huang Shou‑Ming Lv Pan‑He Zhang Jia‑Chen Li Hai‑Yang Zhang Zhen‑Dong Yang Ning Cui Chun Yuan Kun Liu Xiao‑Ai Zhang Jiu‑Song Zhang Hao Li Yang Yang Li‑Qun Fang Wei Liu | 2021 | Infectious Diseases of Poverty2021，10，6： | 3 |
| 10 | A Modified Chi-Squared Goodness-of-Fit Test显示文摘In goodness-of-fit tests,Pearson's chi-squared test is one of most widely used tools of formal statistical analysis.However,Pearson's chi-squared test depends on the partition of the sample space.Different constructions of the partition of the sample space may lead to different conclusions.Based on an equiprobable partition of sample space,a modified chi-squared test is proposed.A method for constructing the modified chi-squared test is proposed.As an application,the proposed test is used to test whether vectorial data come from an uniformity distribution defined on the hypersphere.Some simulation studies show that the modified chi-squared test against different alternative is robust. | DAI Jia Jia YANG Ai Jun | 2009 | Journal of Mathematical Research and Exposition2009，29，1： | 2 |
| 11 | Metal Exposure and Risk of Diabetes and Prediabetes among Chinese Occupational Workers显示文摘Objective To study the association between metal exposure and risk of diabetes and prediabetes among Chinese workers exposed to metals.Methods We used data obtained from the baseline survey of the Jinchang Cohort Study of workers in Jinchang Industry,the largest nickel production company in China.A total of 42,122 workers ≥20 years of age were included in the study.A standardized,structured questionnaire was used to collect epidemiological information.Physical examinations and laboratory tests were conducted to evaluate the health status of the participants and to measure various biomarkers including blood sugar,lipids,and urinary metal concentrations.Logistic regression was used to study the association between occupational groups categorized according to the measured metal levels(office workers,low-level;mining/production workers,mid-level;and smelting/refining workers,high-level)and risk of diabetes and prediabetes.Results The overall prevalence of diabetes and prediabetes was 7.5% and 16.8%,respectively.The adjusted odds ratios for diabetes among mining/production workers and smelting/refining workers compared to office workers were 1.5(95% CI:1.3,1.7)and 3.8(95% CI:3.4,4.3),respectively.No association was observed between these occupational groups and prediabetes in this study.Conclusion Occupations associated with higher levels of metal exposure were associated with an increased risk of diabetes in this cohort.More studies are needed to confirm this observed association. | YANG Ai Min CHENG Ning PU Hong Quan LIU Si Min LI Juan Sheng BASSIG Bryan A. DAI Min LI Hai Yan HU Xiao Bin REN Xiao Wei ZHENG Tong Zhang BAI Ya Na | 2015 | Biomedical and Environmental Sciences2015，28，12： | 2 |
| 12 | Effects of Pb^2+ on the transient outward potassium current in acutely dissociated rat hippocampal neurons显示文摘 | Yu K Ge S Y Dai X Q et aI | 2003 | Can J Physiol Pharmacol2003，81，： | 1 |
| 13 | Role for integrin linked kinase in mediating tubular epithelial to mesenchymal transition and renal inter stitial fibrogenesis显示文摘 | Li Y Yang J Dai C et aI | 2003 | J Clin lnvest2003，112，4： | 1 |
| 14 | A two-level model for the analysis of syndrome of acute ischemic stroke: from diagnostic model to molecular mechanism 显示文摘 | Dai W Liu X Zhang Z et ai | 2013 | Evid Based Complement Alternat Med2013，，29： | 1 |
| 15 | Synthesis and photopolymeriza- tion kinetics of benzophenone piperazine one-component initiator 显示文摘 | Xiao P Wang Y Dai M Z et ai | 2008 | Polymers for Advanced Technologies2008，19，5： | 1 |
| 16 | In vitro and in vivo antitumor effects of doxorubicin loaded with bacterial magnetosomes (DBMs) on H22 cells:The magnetic bio-nanoparticles as drug carriers显示文摘 | Sun JB Duan JH Dai SL et aI | 2007 | Cancer Letters2007，258，12： | 1 |
| 17 | Photol of nanometer zirconia powders 显示文摘 | Li Q F Ai D S Dai X M | 2003 | Powder Technology2003，137，12： | 1 |
| 18 | Hearing evaluation of in- tratympanic methyl prednisolone perfusion for refractory sudden sensorineural hearing loss 显示文摘 | She W Dai Y Du X et ai | 2010 | Otolaryngol Head Neck Surg2010，142，2： | 1 |
| 19 | Supratentorial primitive neuroectodermal tumors of infancy:clinical and radiologic findings显示文摘 | Dai AI Backstrom JW Burger PC | 2003 | Pediatr Neurol2003，29，5： | 1 |
| 20 | Sonic hedgehog expression correlates with distant metastasis in pancreatic adenocarcinoma 显示文摘 | Dai JT Ai KX Du YL | 2011 | Pancreas2011，40，2： | 1 |
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