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| 1 | 脑海绵状血管畸形临床诊疗指南概要:血管瘤联盟科学咨询委员会临床专家组基于系统文献评价的共识推荐显示文摘背景尽管脑海绵状血管畸形(cerebral cavernous malformation, CCM)的相关研究文献已相当丰富,但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体,血管瘤联盟(www.angioma.org)召集了一个包括CCM临床专家在内的多学科写作组来帮助总结现有的CCM临床诊疗相关文献,重点关注5个主题:(1)流行病学和自然病程;(2)遗传检测和咨询;(3)诊断标准和影像学标准;(4)神经外科注意事项;(5)神经内科注意事项。写作组根据预定方案进行了文献回顾和证据评价,最终制定推荐意见,并且确立了共识、争议和知识空白。结果根据方法学标准从1983年1月1日至2014年9月31日期间公开发表的1 270篇文献中筛选出98篇,并确定了另外38篇近期或相关的文献。各主题作者利用这些文献总结了现有知识并形成了23项共识诊疗推荐,同时根据美国心脏协会/美国卒中协会标准进行了推荐强度(效应量)和证据水平(确定性估计)评级。其中,尚无A级证据(因为缺乏随机对照试验),B级证据11项(48%),C级证据12项(52%);Ⅰ级推荐8项(35%),Ⅱ级推荐10项(43%),Ⅲ级推荐5项(22%)。结论现有证据支持对CCM诊疗的推荐,但这些证据的级别和推荐强度普遍较低,因此需要进一步研究来帮助进行更好的临床实践并更新这些推荐。完整的推荐文档包括引用文献的纳入标准、关于各项推荐更详尽的评判标准以及各种争议和知识空白的总结,同样通过了同行评议并可在线获取(www.angioma.org/CCMGuidelines)。 | Amy Akers Rustam Al-Shahi Salman Issam A. Awad Kristen Dahlem Kelly Flemming Blaine Hart Helen Kim Ignacio Jusue-Torres Douglas Kondziolka Cornelia Lee Leslie Morrison Daniele Rigamonti Tania Rebeiz Elisabeth Toumier-Lasserve Darrel Waggoner Kevin Whitehead 鄂同舟 雷宇 倪伟 顾宇翔 | 2017 | 国际脑血管病杂志2017，25，7： | 4 |
| 2 | Novel biomarkers of acute kidney injury: Evaluation and evidence in urologic surgery显示文摘Patients undergoing urologic surgery are at risk of acute kidney injury(AKI) and consequently longterm deterioration in renal function. AKI is further associated with significantly higher odds of perioperative complications, prolonged hospital stay, higher mortality and costs. Therefore, better awareness and detection of AKI, as well as identification of AKI determinants in the urological surgery setting is warranted to pre-empt and mitigate further deterioration of renal function in patients at special risk. New consensus criteria provide precise definitions of diagnosis and description of the severity of AKI. However, they rely on serum creatinine(SCr), which is known to be an inaccurate marker of early changes in renal function. Therefore, several new urinary and serum biomarkers promise to address the gap associated with the use of SCr. Novel biomarkers may complement SCr measurement or most likely improve the diagnostic accuracy of AKI when used in combinations. However, novel biomarkers have to prove their clinical applicability, accuracy, and cost effectiveness prior to implementation into clinical practice. Most preferably, novel biomarkers should help to positively improve a patient's long-term renal functional outcomes. The purpose of this review is to discuss currently available biomarkers and to review their clinical evidence within urologic surgery settings. | Marianne Schmid Deepansh Dalela Rana Tahbaz Jessica Langetepe Marco Randazzo Roland Dahlem Margit Fisch Quoc-Dien Trinh Felix K-H Chun | 2015 | World Journal of Nephrology2015，4，2： | 3 |
| 3 | The human mitochondrial KATP channel is modulated by calcium and nitric oxide:a patch-clamp approach显示文摘 | Dahlem YA Horn TF Buntinas L | 2004 | Biochim Biophys Acta2004，1656，1： | 1 |
| 4 | The multidimensional scale of perceived social support显示文摘 | ZIEMT G D DAHLEM NW ZIMET S G | 1988 | Journal of Personality Assessment1988，，52： | 1 |
| 5 | The multidimensional scale of perceived social support显示文摘 | Zimet GD Dahlem NW Zimet SG | 1988 | Journal of Personality As- sessment1988，52，： | 1 |
| 6 | Incidence and short-term outcome of acute lung injury in mechanically ventilated children显示文摘 | Dahlem P van Aalderen WM Hamaker ME | 2003 | Eur Respir J2003，22，： | 1 |
| 7 | Pediatric acute lung injury 显示文摘 | Dahlem P van Aalderen WM Bos AP | 2007 | Paediatr Respir Rev2007，8，4： | 1 |
| 8 | Incidence and shortterm outcome of acute lung injury in mechanical ventilated children显示文摘 | Dahlem P van Aalderen WM Hanaker ME | 2003 | Eur Respir J2003，22，6： | 1 |
| 9 | The multidimensional scale of perceived social support显示文摘 | Zimet DG Dahlem NW Zimet SG | 1988 | J Pets Assess1988，52，1： | 1 |
| 10 | Self-induced splitting of spiral-shaped spreading depression waves in chicken retina显示文摘 | Dahlem M A Muller S C | 1997 | Exp Brain Res1997，115，2： | 1 |
| 11 | Improved method for purification of toxic peptide produced by cyanobacteria显示文摘 | Harada K-I Suzuki M Dahlem A M | 1988 | Toxicon1988，26，： | 1 |
| 12 | Pediatric acute lung injury显示文摘 | Dahlem P van Aalderen WM Bos AP | 2007 | Paediatr Respir Rev2007，8，4： | 1 |
| 13 | The multidimensional scale of perceived social support显示文摘 | Zimet GD Dahlem NW Zimet SG | 1988 | J Pers Asses1988，52，： | 1 |
| 14 | Improved method for purification of toxic peptides produced by cyanobacteria显示文摘 | Harada K I Suzuki M Dahlem A M | 1988 | Toxicon1988，26，： | 1 |
| 15 | Incidence and short-term outcome of acute lung injury in mechanically ventilated children显示文摘 | Dahlem P VanAalderen WM Hamaker ME | | 0，，6： | 1 |
| 16 | The Multidimensional Scale of Perceived Social Support 显示文摘 | Gregory D Zimet Nancy W Dahlem Sara G Zimet | 1988 | J Pers Assess1988，52，1： | 1 |
| 17 | Improved method for purification of toxic peptides produced by cyanobacteria显示文摘 | Harada K I Suzaki M Dahlem A M | 1988 | Toxicon1988，26，5： | 1 |
| 18 | The multidimen- sional scale of perceived social support显示文摘 | Zimet GD Dahlem NW Zimet SG | 1988 | Journal of Per- sonality Assessment1988，52，1： | 1 |
| 19 | Improved method for purification of toxic peptides produced by cyanobacteria显示文摘 | Harada K I Suzuki M Dahlem A M | 1988 | Toxicon1988，26，5： | 1 |
| 20 | Concomitant toxicokinetics: techniques for and interpretation of exposure data obtained during the conduct of toxicology studies显示文摘 | Dahlem AM Allerheiligen S R Vodicnik M J | 1995 | Toxicol Pathol1995，23，2： | 1 |
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