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| 1 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 2 | Preliminary study on the production of transgenic mice harboring hepatitis B virus X gene显示文摘INTRODUCTIONDespiteoverwhelmingepidemiologicalevidencelinkingpersistentHepatitisBVirus(HBV)infectionandthedevelopmentofhepato... | ZHU Huan Zhang 1, CHENG Guo Xiang 2, CHEN Jian Qu 2, KUANG Shu Yuan 3, CHENG Yong 2, ZHANG Xin Li 1, Ll Hou Da 2, XU Shao Fu 2, SHI Jing Quan 1, QIAN Geng Sun 3 and GU Jian Ren 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 14 |
| 3 | Relationship of particle stimulated nucleation,recrystallization and mechanical properties responding to Fe and Si contents in hot-extruded 7055 aluminum alloys显示文摘The variations of coarse intermetallic particles in hot-extruded 7055 aluminum alloys with 0.041 wt%Fe and 0.024 wt%Si increasing to 0.272 wt%Fe and 0.134 wt%Si were investigated.The particle stimulated nucleation(PSN)behaviors for different kind of coarse particles were detailly analyzed by EBSD.Moreover,the effect of PSN responding to Fe and Si contents on recrystallization and tensile properties of 7055 alloys was evaluated.With increasing Fe and Si contents,the size and number density of coarseη/S particles are reduced,while the number densities of coarse Al7Cu2 Fe and Mg2Si particles are both increased and the coarse Al7Cu2 Fe particles transform from rod-like to irregular.More PSN recrystallized grains with predominant orientations deviated from the extruded fiber textures are stimulated by the irregular Al7Cu2 Fe and Mg2Si particles,because a higher degree of local non-uniform deformation is produced.The rod-like Al7Cu2 Fe particles cause the greatest degree of local non-uniform deformation owing to the largest aspect ratio,but the shape also restricts the area of particle deformation zone(PDZ)resulting in fewer PSN recrystallized grains.The irregularη/S particles give rise to the lowest degree of local non-uniform deformation and fewest PSN recrystallized grains with the major orientations close to the extruded fiber textures.Consequently,despite the number and size of coarseη/S particles are reduced,the proportion of high angle grain boundaries(HAGBs)is increased and the extruded fiber textures are weakened with Fe and Si contents increasing,because of the increased Al7Cu2 Fe and Mg2Si particles.The strength is slightly declined by the weakened<111>//ED(extrusion direction)fiber texture,while the elongation is reduced for a larger number of coarse particles and more HAGBs with higher Fe and Si contents. | Huan She Da Shu Anping Dong Jun Wang Baode Sun Hongchang Lai | 2019 | Journal of Materials Science & Technology2019，35，11： | 10 |
| 4 | A prospective study of vertical transmission of hepatitis C virus显示文摘AprospectivestudyofverticaltransmissionofhepatitisCvirusSUNDeGui1,LIUCaiYun1,MENGZongDa2,SUNYongDe2,WANGShuCong1,YANGYu... | SUN De Gui 1, LIU Cai Yun 1, MENG Zong Da 2, SUN Yong De 2, WANG Shu Cong 1, YANG Yu Qi 1, LIANG Zheng Lun 3 and ZHUANG Hui 3 | 1997 | World Journal of Gastroenterology1997，3，2： | 8 |
| 5 | Two new secoiridoid glycosides from the roots of Picrorhiza scrophulariiflora显示文摘从 Picrorhiza scrophulariiflora 的根,二新 secoiridoid glycosides,命名 picrosecosides 我和 II (1, 2 ) 被孤立。他们的结构根据化学药品和 spectropic 证据被阐明。 | Lian Chun Zou Tong Fei Zhu Shu Cai Gan Da Cheng Wang Yu Zhang Xu Ming Deng | 2008 | Chinese Chemical Letters2008，19，10： | 8 |
| 6 | Flow stress equation for multipass hot-rolling of aluminum alloys显示文摘A series of simple axisymmetric compression tests were carried out on the computer servo controlled Gleeble 1 500 machine when strain rates ranged between 0.05 25 s -1 and deformation temperature 300 500 ℃. The results show that flow stress is related to the Zener Hollonom parameter Z and strain, as well as the static recrystallization fraction between passes during multipass hot deformation of 5182 aluminum alloy. Hence, a modified exponential flow stress equation was presented by considering the values of ln A and β as functions of strain, and by using the uniform softening method and incorporating the static recrystallization fraction between passes to consider the effects of residual strain during multipass hot rolling of 5182 aluminum alloy. The validity of the equation was examined by a typical non isothermal multipass deformation test. | ZHANG Hui,PENG Da shu,YANG Li bin,MENG Li ping (Department of Materials Science and Engineering, Central South University, Changsha 410083, China) | 2001 | Journal of Central South University of Technology2001，8，1： | 7 |
| 7 | Primary evidence for involvement of IP_(3) in heat-shock signal transduction in Arabidopsis显示文摘热吃惊(HS ) 表明的在 transducing 的肌醇 1,4,5-trisphosphate (IP (3 )) 的角色在 Arabidopsis 被检验。整个植物的 IP (3 ) 水平在 37 度 C 在 HS 的 1 min 以内增加了。在 HS 的 3 min 以后, IP (3 ) 水平到达了最大值 2.5 褶层增加。用有 AtHsp18.2 promoter-beta-glucuronidase ( GUS )的转基因的 Arabidopsis 植物熔化基因, GUS 活动的水平在 non-HS 和 HS 温度由将关入笼中的 IP ( 3 )的增加是起来调整的并且由 phospholipase C ( PLC )禁止者是下面调整的,这被发现{1-[6-(( 17beta-3-Methoxyestra-1,3,5 ( 10 ) -trien-17-yl)amino)hexyl]-2,5-pyrro lidinedione }( U-73122 )。细胞内部免费的钙离子集中([Ca (2+)](i)) 在表示 apoaequorin 的暂停有教养的 Arabidopsis 房间在 37 度 C 在 HS 期间增加了。有 U-73122 的处理阻止了增加[Ca (2+)](i) 到某程度。上面的结果在更高的植物在 HS 信号 transduction 为 IP (3 ) 的可能的参与提供了主要证据。 | Hong Tao Liu Fei Gao Shu Juan Cui Jin Long Han Da Ye Sun Ren Gang Zhou | 2006 | Cell Research2006，16，4： | 7 |
| 8 | Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor显示文摘蛋白质酷氨酸磷酸酶 1B (PTP1B ) 作为一个否定管理者起一个重要作用并且被证明了是为类型 2 糖尿病 mellitus 的处理的一个有效目标。二度 --(2,3-dibromo-4,5-dihydroxyphenyl ) 甲烷 7 首先对从红水藻 Rhodomela confervoides 被孤立的 PTP1B 与重要抑制作为自然 bromophenol 被报导。由它的令人震惊的活动好奇(IC50 = 2.4 渭 m ol/L ) ,化合物 7 与 24% 的全面收益被综合并且与自然化合物相比为它的 PTP1B 禁止的活动评估了。 | Jing Li Shu Ju Guo Hua Su Li Jun Han Da Yong Shi | 2008 | Chinese Chemical Letters2008，19，11： | 6 |
| 9 | Chemical Studies on the Glycosides in the Leaves of Oplopanax Elatus Nakai(Ⅳ)显示文摘ChemicalStudiesontheGlycosidesintheLeavesofOplopanaxElatusNakai(Ⅳ)*WANGGuang-shuandXUJing-da(NormanBethuneUniversityofMedical... | WANG Guang shu and XU Jing da (Norman Bethune University of Medical Sciences, Changchun, 130021) MA Xiu li, SUN Yun xiu and LIU Ju zheng (Department of Chemistry, Jilin University, Changchun, 130023) Tetsuya Murayama and Junzo Shoji (Schoo | 1997 | Chemical Research in Chinese Universities1997，13，1： | 6 |
| 10 | Adaptive backtracking search optimization algorithm with pattern search for numerical optimization显示文摘The backtracking search optimization algorithm(BSA) is one of the most recently proposed population-based evolutionary algorithms for global optimization. Due to its memory ability and simple structure, BSA has powerful capability to find global optimal solutions. However, the algorithm is still insufficient in balancing the exploration and the exploitation. Therefore, an improved adaptive backtracking search optimization algorithm combined with modified Hooke-Jeeves pattern search is proposed for numerical global optimization. It has two main parts: the BSA is used for the exploration phase and the modified pattern search method completes the exploitation phase. In particular, a simple but effective strategy of adapting one of BSA's important control parameters is introduced. The proposed algorithm is compared with standard BSA, three state-of-the-art evolutionary algorithms and three superior algorithms in IEEE Congress on Evolutionary Computation 2014(IEEE CEC2014) over six widely-used benchmarks and 22 real-parameter single objective numerical optimization benchmarks in IEEE CEC2014. The results of experiment and statistical analysis demonstrate the effectiveness and efficiency of the proposed algorithm. | Shu Wang Xinyu Da Mudong Li Tong Han | 2016 | Journal of Systems Engineering and Electronics2016，27，2： | 5 |
| 11 | Association between ApoE Polymorphism and Type 2 Diabetes: A Meta-Analysis of 59 Studies显示文摘Objective To identify the important risk factors for type 2 Diabetes Mellitus(T2 DM) and develop effective strategies to address the problem of T2 DM. Our study aimed to evaluate the association between apolipoprotein E(Apo E) genetic polymorphism and type 2 diabetes, and to provide clues for the etiology of T2 DM.Methods Based on the criteria of inclusion and exclusion, we extracted, pooled, analyzed and assessed the case-control studies of Apo E polymorphism and T2 DM published in Pub Med, Web of Science,Medline, Wan Fang, VIP, and CNKI databases by R soft-ware(version 3.4.3). We used Random-effect models when heterogeneity was present in between-study, and fixed-effect models otherwise.Results We had 59 studies covering 6,872 cases with T2 DM and 8,250 controls, and compared the alleles and genotypes of Apo E between cases and controls. When we conducted a comparison between Apo E ε4 and ε3 alleles, we produced a pooled OR of 1.18(95% CI: 1.09-1.28;P < 0.001). Apo E ε2/ε2 genotype displayed a possible association with T2 DM(OR = 1.46;95% CI: 1.11-1.93;P = 0.007), ε3/ε4 genotype showed a 1.11-fold risk(OR = 1.11;95% CI: 1.01-1.22;P = 0.039) and ε4/ε4 genotype had a1.71-fold risk of developing T2 DM(OR = 1.71;95% CI: 1.33-2.19;P < 0.001) when they were compared with ε3/ε3 genotype.Conclusions There is an association between Apo E polymorphism and T2 DM: allele ε4 and genotypes(ε2/ε2, ε3/ε4, and ε4/ε4) are associated with the increased risk for the development of T2 DM, and they may be risk factors for T2 DM. | CHEN Da Wei SHI Ji Kang LI Yun YANG Yu REN Shu Ping | 2019 | Biomedical and Environmental Sciences2019，32，11： | 4 |
| 12 | Effects of Mg Addition on Inclusions Formation and Resultant Solidification Structure Changes of Ti-stabilized Ultra-pure Ferritic Stainless Steel显示文摘The effects of Mg addition on the formation of nonmetallic inclusions and solidification structure of Ti-stabilized ultra-pure ferritic stainless steels were investigated by experimentally casting ingots with different compositions.Thermodynamic analyses on the formation of complex inclusions after adding Mg into steels were carried out combined with the scanning electron microscopy-energy dispersive spectrometry(SEM-EDS)analysis.And the EDS analysis showed that in steel samples with Mg addition,a new spinel crystal phase combined with Al2O3-TiOx formed.It was also found that after Mg addition,the proportions of equiaxed grain zone of 409L,4003,439 and 443NT steels increased from 10.2%,21.8%,13.4% and 18.6% to 84.3%,92.3%,91.1% and 100.0%,respectively.Since the planar disregistry between spinel and TiN is 5.1%,spinel could promote the precipitation of TiN and increase the number density of TiN inclusions in steel melts.The mechanism of solidification structure refinement after adding Mg into steels supposed that the complex inclusions of spinel and TiN in high number density enhanced columnar-to-equiaxed transition,since the planer disregistry betweenδphase and spinel is 1.4%. | Ying-tie XU Zhao-ping CHEN Mao-tao GONG Da SHU Yue-mei TIAN Xiang-qian YUAN | 2014 | Journal of Iron and Steel Research(International)2014，21，6： | 4 |
| 13 | Development of Chinese hybrid radiation adult phantoms and their application to external dosimetry显示文摘This paper presents the construction of Chinese hybrid radiation adult phantoms,which are compatible with anatomical parameters for the Chinese reference population.The phantoms were designed using polygonal mesh surface,which makes the phantom more flexible and realistic than previous generations.Voxelization of hybrid phantoms was performed to adopt Monte Carlo methods.External dose coefficients were calculated by Geant4 and compared to the ICRP reference phantom.The results show that the organ dose is different from ICRP116 with the low energy photons,which can be ascribed to the anatomy and topology difference of each organ.The effective dose of CHRAP is 19%higher than ICRP 116 in the energy range from10 to 100 keV and is almost the same in the energy range from 100 keV to 10 MeV.These phantoms can be used as the basic phantom to adjust the posture or organ volume to estimate dosimetry in medical and space explorations. | GENG ChangRan TANG XiaoBin HOU XiaoXiao SHU DiYun CHEN Da | 2014 | Science China(Technological Sciences)2014，57，4： | 4 |
| 14 | Interferon-induced Transmembrane Protein 3 Prevents Acute Influenza Pathogenesis in Mice显示文摘Objective Interferon-induced transmembrane protein 3(IFITM3)is an important member of the IFITM family.However,the molecular mechanisms underlying its antiviral action have not been completely elucidated.Recent studies on IFITM3,particularly those focused on innate antiviral defense mechanisms,have shown that IFITM3 affects the body’s adaptive immune response.The aim of this study was to determine the contribution of IFITM3 proteins to immune control of influenza infection in vivo.Methods We performed proteomics,flow cytometry,and immunohistochemistry analysis and used bioinformatics tools to systematically compare and analyze the differences in natural killer(NK)cell numbers,their activation,and their immune function in the lungs of Ifitm3-/-and wild-type mice.Results Ifitm3-/-mice developed more severe inflammation and apoptotic responses compared to wild-type mice.Moreover,the NK cell activation was higher in the lungs of Ifitm3-/-mice during acute influenza infection.Conclusions Based on our results,we speculate that the NK cells are more readily activated in the absence of IFITM3,increasing mortality in Ifitm3-/-mice. | SUN Qiang LEI Na LU Jian GAO Rong Bao LI Zi LIU Li Qi SUN Ying GUO Jun Feng WANG Da Yan SHU Yue Long | 2020 | Biomedical and Environmental Sciences2020，33，5： | 4 |
| 15 | Controllable synthesis of well-ordered TiO_2 nanotubes in a mixed organic electrolyte for high-efficiency photocatalysis显示文摘Well-ordered TiO 2 nanotube arrays (TNAs) were fabricated by electrochemical anodization in a mixed organic electrolyte consisting of ethylene glycol and glycerol. The morphology, structure, crystalline phase, and photocatalytic properties of TNAs were characterized by using TEM, SEM, XRD and photodegradation of methylene blue. It was found that the morphology and structure of TNAs could be significantly influenced by the anodization time and applied voltage. The obtained tube length was found to be proportional to anodization time, and the calculated growth rate of nanotubes was 0.6 m/h. The microstructure analysis demonstrated that the diameter and thickness of the nanotubes increased with the increase of anodization voltage. The growth mechanism of TNAs was also proposed according to the observed relationship between current density and time during anodization. As expected, the obtained TNAs showed a higher photocatalytic activity than the commercial TiO 2 P25 nanoparticles. | WANG Chao CHEN Da PING GuangXing LIU Shu HUANG XiaNi HUANG YueXiang SHU KangYing LI JingHong | 2012 | Science China Chemistry2012，55，11： | 3 |
| 16 | Electromagnetic Filtration of Primary Fe-Rich Phases from Al-Si Alloy Melt显示文摘Electromagnetic filtration of primary Fe-rich phases (complex compound of AlFeSiMn) from Al-Si alloy melt containing 1.2 wt pct Fe have been studied by theoretical analysis and on a self-designed electromagnetic filtration equipment. The principle of the electromagnetic filtration is that the EMF (electromagnetic force) scarcely acts on the primary Fe-rich phases having low electric conductivity, which are then moved in the direction opposite to that of the EMF. Experimental results show that the primary Fe-rich phases are separated from Al-Si alloy melt and are collected in the filter while the melt is in horizontal flow. The removal efficiency of the primary iron-phases (77) calculated is less as the greatest flow velocity of the melt (UM) and the height of the filter (2h) are larger, while it becomes larger as EMF, operating distance of electromagnetic force (cr) and particle size (dv) become larger. It has been confirmed that the primary iron-phases larger than 20 jim can be removed efficiently by theoretical analysis and experiments. This new technique is high efficient and available for continuously flowing melts as compared with natural settling and filtration methods, which offer a possibility for recycling high quality aluminum alloys. | Zhenming XU, Tianxiao LI, Da SHU and Yaohe ZHOU School of Materials Science and Engineering, Shanghai Jiaotong University, Shanghai 200030, China E-mail: zmxu@mail1.sjtu.edu.cn | 2001 | Journal of Materials Science & Technology2001，17，3： | 3 |
| 17 | Ag_2S-石墨烯/TiO_2的声化学法合成及可见光催化活性(英文)显示文摘Ag2S‐graphene/TiO2 composites were synthesized by a facile sonochemical method.The products were characterized by X‐ray diffraction,scanning electron microscopy,energy dispersive X‐ray spectroscopy,transmission electron microscopy,and UV‐Vis diffuse reflectance spectrophotometry.During the synthesis reaction,the reduction of graphene oxide and loading of Ag2S and TiO2 particles were achieved.The Ag2S‐graphene/TiO2 composites possessed a large adsorption capacity for dyes,an extended light absorption range,and efficient charge separation properties.Hence,in the photodegradation of rhodamine B,a significant enhancement in the reaction rate was observed with the Ag2S‐graphene/TiO2 composites as compared to pure TiO2.The generation of reactive oxygen species was detected by the oxidation of 1,5‐diphenyl carbazide to 1,5‐diphenyl carbazone.The high activity was attributed to the synergetic effects of high charge mobility and the red shift in the absorption edge of the Ag2S‐graphene/TiO2 composites. | Ze‐Da Meng Lei Zhu Kefayat Ullah Shu Ye Qian Sun Won‐Chun Oh | 2013 | 催化学报2013，34，8： | 3 |
| 18 | A New Anti-Collision Algorithm for Multi-Target Real Time Recognitionin RFID System显示文摘The problem of how to distinguish and recognize more than one target when they are entering the working area of the Radio Frequency Identification( RFID ) system should be considered in design of the system. To avoid signal interference with each other among all targets, an anti collision algorithm as well as the condition of working stability is proposed. The computer simulation shows that the new algorithm will be of advantages in the process of system design. | SHEN Yu chao, WANG Hai bo, SHEN Shu qun, XU Da xiong (School of Electronic Engineering,Beijing University of Posts and Telecommunications,Beijing 100876,P.R.China) | 2000 | The Journal of China Universities of Posts and Telecommunications2000，7，3： | 3 |
| 19 | Ultrastructural observation of liver tissue ablation induced by high-intensity focused ultrasound显示文摘UltrastructuralobservationoflivertissueablationinducedbyhighintensityfocusedultrasoundCHENGShuQun1,ZHOUXinDa1,TANGZhaoYo... | CHENG Shu Qun 1, ZHOU Xin Da 1, TANG Zhao You 1, YU Yao 1, BAO Su Su 2 and QIAN De Chu 2 | 1997 | World Journal of Gastroenterology1997，3，3： | 2 |
| 20 | Effects of light on cyanide‐resistant respiration and alternative oxidase function in Arabidopsis seedlings显示文摘 | DA‐WEIZHANG FEIXU ZHONG‐WEIZHANG YANG‐ERCHEN JUN‐BODU SHU‐DANJIA SHUYUAN HONG‐HUILIN | 2010 | Plant, Cell & Environment2010，，12： | 2 |
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