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| 1 | A Novel Sesquiterpene Polyol Ester from Celastrus Angulatus and its Antitumor Activities显示文摘A new sesquiterpene polyol ester was isolated from the leaves of Celastrus angulatus. itsstructure was determined as 1 6. 2 6. 9 a-triacetoxy-8 a-(a-hydroxyl-isobutyryloxy)-15-benzoyloxy-4 a-hydroxy-dihydroagarofuran by means of NMR. MS and IR spectral analysis.Preliminary biological study on antitumor activity revealed that this compound showed strongnonselective cytotoxicity against four of the NCI panel cell lines. | Wei Ping YIN Tian Zeng ZHAO Ling Jie GAO Da Peng ZOU Jian Xun KANG(Institute of Chemistry,Henan Academy of Sciences Zhengzhou 450003 Centre of Instrumental Analysis. Zhengzhou University. Zhengzhou 450052) | 1999 | Chinese Chemical Letters1999，10，6： | 2 |
| 2 | Studies on the Synthesis and Complexing Behavior of Crown Ethers with External Coordination Center显示文摘The synthesis, characterization of five ditopic or tritopic crown compounds were reported in this paper together with the preparation of the corresponding hetero-dinuclear and hetero-trinuclear complexes with different metal cations. | Jing Chao TAO, Yang Jie WU*, Shang Jie XU, Da Peng ZOU Department of Chemistry, Zhengzhou University, Zhengzhou 450052 | 2001 | Chinese Chemical Letters2001，12，6： | 1 |
| 3 | Expert Consensus on Nutritional Support for Children with Congenital Heart Disease(2023 Edition)显示文摘The second edition of the expert consensus on pediatric nutrition was formed based on a global update of pedia-tric nutrition guidelines or consensus worldwide,the management of congenital heart disease,and the results of multi-center clinical nutrition research for congenital heart disease following thefirst Chinese consensus edition of 2016.The consensus was also shaped by the results of three discussion sessions and two questionnaires con-ducted by the 13-member collaboration group.This process was informed by both clinical guidelines and expert consensus.The quality of literature,both in English and Chinese,and the level of recommendations were evaluated using the Grading of Recommendations Assessment,Development,and Evaluations(GRADE)system. | Xuming Mo Wei Cai Jirong Qi Zhuoming Xu Ying Wang Weihui Yan Shoujun Li Nianguo Dong Xinxin Chen Jinfen Liu Qiang Shu Jimei Chen Haibo Zhang Hao Zhang Quansheng Xing Qi An Xiaofeng Li Xu Wang Yan He Junwu Su Taibing Fan Teng Ming Weibing Tang Li Hong Jinghao Zheng Ming Ye Guocheng Sun Yiqun Ding Liang Tao Yifeng Yang Zhongshi Wu Hua Cao Qiang Wang Keming Yang Libing Zhang Ping Wen Yanqin Cui Bo Zhai Yong Zou Qingya Tang Rui Chen Chun Wu Zhiyu Feng Caixia Liu Yaping Mi Rufang Zhang Ke Lin Xin Li Mingan Pi Xiangming Fan Shanshan Shi Peng Huang Zhengxia Pan Jiafeng Qi Renwei Chen Shuguang Tao Yaqin Shu Huifeng Zhang Lan Jiang Min Da Nishant Patel Liang Hu Cardiac Surgery Group of Pediatric Surgery Society of Chinese Medical Association and Parenteral Enteral Nutrition Society of Chinese Medical Association | 2023 | Congenital Heart Disease2023，18，6： | 0 |
| 4 | The burgeoning importance of PIWI-interacting RNAs in cancer progression显示文摘PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ cells.Recent studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and stemness.Additionally,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of tumors.Nonetheless,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully comprehended.This review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer. | Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying Sun Zhangling Wang Yongluo Jiang Xuan Miao Yixuan Yan Hailin Tang Lewei Zhu Yutian Zou Peng Liu | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 5 | An FPGA‑based trigger system for CSHINE显示文摘A trigger system of the general function was designed using the commercial module of CAEN V2495 for heavy-ion nuclear reaction experiments at Fermi energies.The system was applied and verified on the compact spectrometer for heavy IoN experiment(CSHINE).Based on the field-programmable logic gate array technology of the command register access and remote computer control operation,trigger functions can be flexibly configured according to experimental physical goals.Using the trigger system on CSHINE,we conducted a beam experiment at 25 MeV/u^(86)Kr+^(124)Sn on the Radioactive Ion Beam Line 1 in Lanzhou,China.The online results demonstrated that the trigger system worked normally and correctly.This system can be extended to other experiments as well. | Dong Guo Yu‑Hao Qin Sheng Xiao Zhi Qin Yi‑Jie Wang Fen‑Hai Guan Xin‑Yue Diao Bo‑Yuan Zhang Yao‑Peng Zhang Da‑Wei Si Shi‑Wei Xu Xiang‑Lun Wei He‑Run Yang Peng Ma Tian‑Li Qiu Hai‑Chuan Zou Li‑Min Duan Zhi‑Gang Xiao | 2022 | Nuclear Science and Techniques2022，33，12： | 0 |
| 6 | Reprogramming Mycobacterium tuberculosis CRISPR System for Gene Editing and Genomewide RNA Interference Screening显示文摘Mycobacterium tuberculosis is the causative agent of tuberculosis(TB), which is still the leading cause of mortality from a single infectious disease worldwide. The development of novel anti-TB drugs and vaccines is severely hampered by the complicated and time-consuming genetic manipulation techniques for M. tuberculosis. Here, we harnessed an endogenous type Ⅲ-A CRISPR/Cas10 system of M. tuberculosis for efficient gene editing and RNA interference(RNAi).This simple and easy method only needs to transform a single mini-CRISPR array plasmid, thus avoiding the introduction of exogenous protein and minimizing proteotoxicity. We demonstrated that M. tuberculosis genes can be efficiently and specifically knocked in/out by this system as confirmed by DNA high-throughput sequencing. This system was further applied to single-and multiple-gene RNAi. Moreover, we successfully performed genome-wide RNAi screening to identify M. tuberculosis genes regulating in vitro and intracellular growth. This system can be extensively used for exploring the functional genomics of M. tuberculosis and facilitate the development of novel anti-TB drugs and vaccines. | Khaista Rahman Muhammad Jamal Xi Chen Wei Zhou Bin Yang Yanyan Zou Weize Xu Yingying Lei Chengchao Wu Xiaojian Cao Rohit Tyagi Muhammad Ahsan Naeem Da Lin Zeshan Habib Nan Peng Zhen F.Fu Gang Cao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 0 |
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