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| 1 | Can ultrasound predict the severity of acute pancreatitis early by observing acute fluid collection?显示文摘INTRODUCTIONThe spectrum of acute pancreatitis (AP) ranges from a mild spontaneously resolved disorder to severe disease with mortality up to 20%-48.4%[1-3]. sAP is defined as the AP with organ failure and /or local complications which developed form acute fluid collection (AFC) including necrosis ,abscess , pseudocyst formation into or around the pancreas [4]. | Yan Luo1 Chao Xin Yuan1 Yu Lan Peng1 Pei Lin Wei1 Zhao Da Zhang2 Jun Ming Jiang3 Lin Dai1 Yun Kai Hu1 1Ultrasound Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China2Surgery Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China3Tranditional Chinese Medicine, Department of First Affiliated Hospital of West China University of Medical Science, Chengdu 610041, Sichuan Province, China | 2001 | World Journal of Gastroenterology2001，7，2： | 8 |
| 2 | Jurassic Black Shales Facies from Qiangtang Basin (Northern Tibet): Rare Earth and Trace Elements for Paleoceanographic Implications显示文摘The Biluo Co and Amdo 114 station, northern Tibet, cropping out the Early Toarcian and Middle-Late Tithonian (Jurassic) organic-rich black shales, have been a focus to petroleum geologists in discussing their oil-producing potential. This paper first reports the trace elements and rare earth elements to discuss the paleoenvironments, redox conditions and sedimentary mechanisms of those black shales. Both sections exhibit variation in trace element abundances with concentrations <0.1 ppm to 760 ppm, mostly enriched in V, Cr, Ni, Cu, Zn, Mo, Ba and U. Element ratios of Ni/Co, V/Cr, U/Th and V/(V+Ni) plus U were used to identify redox conditions. The shale-normalized rare earth element (REE) patterns are characterized by the flat-shale type with instable Ce anomalies and very weekly positive Eu anomalies. Positive Ceanom values are significant with values varying between - 0.064 and 0.029 in Biluo Co, which may be interpreted as release of REE and input of riverine terrestrial matter with rich Ce (resulting in pH change) during the anoxic conditions. In the middle parts of Amdo 114 station, distinct negative Ceanom values are observed (-0.238 to -0.111) and associated surface water warming were interpreted as being related to a major sea level rise. In contrast, the formation of the black shales in the lower and upper part of the studied succession took place during a cooler (Ceanom values >-0.10), lower surface water productivity, and lower sea-level stage. Thus, we emphasize the role of different factors that control the formation of local and regional black shales. The most important factors are sea-level fluctuations and increasing productivity. | CHEN Lan YI Haisheng TSAI Louis Loung-Yie XU Guiwen DA Xuejuan LIN Andrew Tien-Shun | 2013 | Acta Geologica Sinica(English Edition)2013，87，2： | 4 |
| 3 | Transcription of the putative tumor suppressor gene HCCS1 requires binding of ETS-2 to its consensus near the transcription start site显示文摘hepatocellular 癌压制或 1 (HCCS1 ) 基因被在肝癌症的从杂合现象(17p13.3 ) 的损失的一个占优势的区域的两位置的克隆并且由为在大规模 transfection 试金影响房间增长的基因的功能的屏蔽识别。它的过去在在房间文化的房间增长和在裸体鼠标的肿瘤生长的抑制的表达式结果。理解它的抄写规定,倡导者建筑学详细被把了。抄写的主要开始被对 C 残余的教材扩展印射, ATG 在上游的 177 核苷酸上哄骗。由在短暂 transfection 试金估计最小的倡导者(到 +148 区域的 -60 )的一套扫描连接器的异种的倡导者活动,我们发现 +1 到 40 区域是的+对 HCCS1 基因抄写批评,为抄写因素 NF-kappaB (到 +7 的 -21 和到 +26 的 +40 )的包含的有约束力的地点, p53 (到 +9 的 +29 )和 et (到 +20 的 +4 和到 +39 的 +23 )。生物化学、分子的分析表明 ETS 抄写因素 ETS-2 和 Elf-1 在 situ 绑在二个 et 地点并且显著地作出贡献到抄写结盟 HCCS1 基因的活跃状态,当时 NF-kappaB , p53 和 ETS 家庭( ETS-1 和 NERF2 )的二个另外的成员看起来起很少作用。我们的观察提供卓见进 HCCS1 抄写规定的机械学的方面。房间研究(2006 ) 16:780-796。做 i:10.1038/sj .cr.7310092;出版联机 2006 年 9 月 5 日。 | Jing De Zhu Qi Fei Peng Wang Fei Lan Da Qin Mao Hong Yu Zhang Xue Biao Yao | 2006 | Cell Research2006，16，9： | 3 |
| 4 | Effects of IκBα and its mutants on NF-κB and p53 signaling pathways显示文摘AIM: To study the effects of IκBα and its mutants (IκBαM, IκBα243N, IκBαM244C) on NF-κB, p53 and their downstream target genes. The relationship of NF- κB, p53, and IκBα was further discussed.METHODS: pECFP-IκBα, pECFP-IκBαM (amino acides 1-317, Ser32, 36A), pECFP-IκBα243N (amino acides 1-243), pECFP-IκBα244C (amino acides 244-317), pEYFP-p65 and pp53-DsRed were constructed and transfected to ASTC-α-1 cells. Cells were transfected with pECFP-C1 as a control. 30 h after the transfection, location patterns of NF-κB, p53 and IκBα (IκBαM, IκBα243N, IκBα244C) were observed by a laser scanning microscope (LSM510/ConfoCor2, Zeiss). RNA extraction and reverse transcription were performed in cells transfected or co-transfected with different plasmids. Effects of IκBα and its mutants on the transprition level of NF-κB, NF-κB downstream target gene TNF-α, p53 and p53 downstream target gene Bax were observed by real time QT-PCR. In all experiments β-actin was reference. Results are expressed as the target/reference ratio of the sample divided by the target/reference ratio of the control. Different transfected cells were incubated with CCK-8 for 2 h in the incubator. Then the absorbance at 450 nm was measured by using a microplate reader. RESULTS: Cells that were transfected with p53- DsRed revealed a predominant nuclear localization. YFP-p65 mainly existed in the cytoplasm. Cells were transfected with CFP-IκBα, CFP-IκBαM, and CFP- IκBα243N respectively and revealed a predominant cytosolic localization. However, cells transfected of CFP- IκBα244C revealed a predominant nuclear localization. The mRNA levels of p65, TNF-α, p53 and Bax in CFP-IκBα transfected cells did not change significantly, while in YFP-p65/CFP-IκBα co-transfected cells, IκBα decreased the transcription of p65 downstream gene TNF-α (2.24 ± 0.503) compared with the YFP-p65/ CFP-C1 co-transfected cells (5.08 ± 0.891) (P < 0.05). Phosphorylation defective IκBα (IκBαM) decreased the transcription levels of all the four genes compared with the control (P < 0.05). The N terminus of IκBα (IκBα243N) increased the transcription of NF-κB (1.84 ± 0.176) and TNF-α (1.51 ± 0.203) a little bit. However, the C terminus of IκBα (IκBα244C) increased the transcription of NF-κB, TNF-α, p53 and Bax significantly (8.29 ± 1.662, 14.16 ± 2.121, 10.2 ± 0.621, 3.72 ± 0.346) (P < 0.05). The CCK-8 experiment also showed that IκBα244C and p53 synergistically mediate apoptosis. CONCLUSIONS: IκBα and its mutants (IκBαM, IκBα243N, IκBαM244C) have different effects on NF- κB and p53 signaling pathways, according to their different structures. IκBαM bounds with NF-κB and p53 in cytoplasm steadily, and inhibits both of the two signaling pathways. p53 and IκBα244C may be co-factor in inducing apoptosis. The C terminal of IκBα enhanced cell death, which suggests that it may be a pro-apoptotic protein existed in cells. | Xian Li Da Xing Ju Wang De-Bin Zhu Lan Zhang Xiao-Jia Chen Fen-Yong Sun An Hong | 2006 | World Journal of Gastroenterology2006，12，41： | 3 |
| 5 | Chemo-and Biostratigraphy of the Jurassic Oil Shales from the Qiangtang Basin,Northern Tibet,China:A Case Study of the Toarcian Oceanic Anoxic Event显示文摘The marine oil shales of the Qiangtang Basin, northern Tibet, exposed in the Biluo Co, Tuonamu, Shenglihe and Changsheshan areas are believed to be important petroleum source rocks. This work comprehensively analyzed the carbon isotopes, trace elements, and calcareous nannofosills, ammonites and bivalves of the Biluo Co section in the Qiangtang Basin. The organic carbon isotopes show a positive excursion close to 2.17‰(relative to PDB), which, albeit significantly smaller, may also be associated with other Early Toarcian Oceanic Anoxic Events(T-OAE) in the European epicontinental seas and the Tethyan continental margins. Coinciding with the Early Toarcian transgression, the oxygen deficiency in bottom water had led to dysoxic-anoxic conditions and deposition of black shales lacking benthic fauna. Under such condition, the redox-sensitive trace metals such as Mo, V, Ni, Cr, and U were enriched, in conjunction with high planktonic productivity of Watznaueriaceae calcareous nannofossils. Comparison of the results with the records of chemo-and biostratigraphy, as well as the palaeogeography during the Early Jurassic suggests that the anoxia linked to the Early Toarcian oceanic anoxic event was mainly caused by the high surface water temperature, sea-level rise and an increase of surface water productivity. | CHEN Lan XU Guiwen DA Xuejuan YI Haisheng ZHU Zhangxiong HUANG Zhaohui LI Xiaogang | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 2 |
| 6 | A Novel Real-time Fluorescence Mutant-allele-specific Amplification Method for Rapid Single Nucleotide Polymorphism Analysis显示文摘为单个核苷酸多型性(SNP ) 的当前的方法分析消费 aretime 并且复杂。我们为快速的 SNP 分析在一步舞的开发瞄准了即时 fluorescencemutant-allele-specific 扩大(MASA ) 方法。方法是二种技术的婚姻:为目标脱氧核糖核酸和 双stranded 的 MASA 教材DNA选择的荧光染料,格林·西布尔 I.Genotypes 根据thewild类型的不同阀值周期被分开,变异的primers.K地岬 oncogene 被用作一个目标验证不同遗传型能清楚地是,这试金区别的试验性的结果显示出的 themethod.The 的可行性。即时荧光 MASA 方法将由于它的简洁和低费用为快、可靠的 SNP 分析有一个庞大的潜力。 | De Bin ZHU Da XING Xian LI Lan ZHANG | 2006 | Chinese Chemical Letters2006，17，4： | 1 |
| 7 | Asymmetric interfaces and high-TC ferromagnetic phase in La_(0.67)Ca_(0.33)MnO_(3)/SrRuO_(3)superlattices显示文摘Interfacial magnetism in functional oxide heterostructures not only exhibits intriguing physical phenomena but also implies great potential for device applications.In these systems,interfacial structural and electronic reconstructions are essential for improving the stability and tunability of the magnetic properties.In this work,we constructed ultra-thinLa_(0.67)Ca_(0.33)MnO_(3)/SrRuO_(3)(SRO)layers into superlattices,which exhibited a robust ferromagnetic phase.The high Curie temperature(TC)reaches 291 K,more than 30 K higher than that of bulk LCMO.We found that the LCMO/SRO superlattices consisted of atomically-sharp and asymmetric heterointerfaces.Such a unique interface structure can trigger a sizable charge transfer as well as a ferroelectric-like polar distortion.These two interfacial effects cooperatively stabilized the high-T_(C)ferromagnetic phase.Our results could pave a promising approach towards effective control of interfacial magnetism and new designs of oxide-based spintronic devices. | Lili Qu Da Lan Liang Si Chao Ma Shasha Wang Liqiang Xu Kexuan Zhang Feng Jin Zixun Zhang Enda Hua Binbin Chen Guanyin Gao Feng Chen Haifeng Du Karsten Held Lingfei Wang Wenbin Wu | 2021 | Nano Research2021，14，10： | 1 |
| 8 | Serological screening and toxoplasmosis exposure factors among pregnant women in the Democratic Republic of Sao Tome and Principe显示文摘 | Chien-Ching Hung Chia-Kwung Fan Kua-Eyre Su Fung-Chang Sung Hung-Yi Chiou Vilfrido Gil Maria da Conceicao dos Reis Ferreira Jose Manuel de Carvalho Claudina Cruz Yu-Kuan Lin Lian-Fen Tseng Ke-Yun Sao Wen-Cheun Chang Hung-Shue Lan Shing-Hsien Chou | 2006 | Transactions of the Royal Society of Tropical Medicine and Hygiene2006，，2： | 1 |
| 9 | Regulation of matrix metalloproteinase 9 expression by Epstein-Barr virus nuclear antigen 3C and the suppressor of metastasis nm23-H1显示文摘 | Lan K Knight JS | 2005 | J Virol2005，79，15： | 1 |
| 10 | Myofibroblast induction with transforming growth factor-betal and beta3 in cutaneous fetal excisional wounds显示文摘 | Lanning DA Diegelmann RF Yager DR | 2000 | J Pediatr Surg2000，35，2： | 1 |
| 11 | Generation and life cycle of the dipole in the South China Sea summer circulation 显示文摘 | WANG Gui hua CHEN Da ke SU Ji lan | | Journal of Geophysical Research-Oceans0，111，06： | 1 |
| 12 | Deficiency of NOX1 or NOX4 prevents liver inflammation and fibrosis in mice through inhibition of hepatic stellate cell activation 显示文摘 | Lan T Kisseleva T Brenner DA | 2015 | PLoS One2015，10，01： | 1 |
| 13 | Cyclin D1 splice variants: Diftbrential effects on localization,RB phosphorylation and cellular transformation 显示文摘 | Solomon DA Wang Y Fox SR Lambeck TC Giesting S Lan Z | 2003 | J Biol Chem2003，278，30： | 1 |
| 14 | Regulation of matrix metallo- proteinase-9 expression by Epstein-Barr virus nuclear antigen 3C and the suppressor of metastasis nm23-H1 显示文摘 | Kuppers DA Lan K Knight JS | 2005 | J Virol2005，79，15： | 1 |
| 15 | Comparative proteomic profiles indicating genetic factors may involve in hepatocellular carcinoma familial aggregation显示文摘 | Da‐Ni Zhong Qiu‐Yue Ning Ji‐Zhou Wu Ning Zang Jian‐Lin Wu Die‐Fei Hu Shuang‐Yan Luo Ai‐Chun Huang Lan‐Lan Li Guo‐Jian Li | 2012 | Cancer Sci2012，，10： | 1 |
| 16 | 2010Rheum atoid arthritisclassification criteria: an A m erican College ofR heum atology/E uropean League A gainst R heum atismcollaborative initiative显示文摘 | Da niel A- Tuhina N - A lan S | 2010 | A nn Rheum D is2010，69，： | 1 |
| 17 | TGF-3 alters the healing of cutaneous fetal excisional wounds 显示文摘 | Lanning DA Nwomeh BC Montante SJ | 1999 | J Pediatr Surg1999，34，： | 1 |
| 18 | TNFα Induces Apoptosis Through JNK/Bax-dependent Pathwayin Differentiated, but Not Naive PC12 Cells 显示文摘 | ZHANG Lan XING Da LIU Lei | 2007 | Cell Cycle2007，6，12： | 1 |
| 19 | Induction of Kaposi'ssarcoma-associated herpesvirus latency-associated nuclear antigenby the lytic transactivator RTA: a novel mechanism for estahlish-ment of latency显示文摘 | LAN K KUPPERS DA VERMA SC | 2005 | J Virol2005，79，12： | 1 |
| 20 | Enhanced oral bioavailability and anti‐tumour effect of paclitaxel by 20(s)‐ginsenoside Rg3 in vivo显示文摘 | Lei‐Qiong Yang Bin Wang Hui Gan Shou‐Ting Fu Xiao‐Xia Zhu Zhuo‐Na Wu Da‐Wei Zhan Ruo‐Lan Gu Gui‐Fang Dou Zhi‐Yun Meng | 2012 | Biopharm Drug Dispos2012，，8： | 1 |
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