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| 1 | No difference in mortality among ALPPS,two-staged hepatectomy,and portal vein embolization/ligation:A systematic review by updated traditional and network meta-analyses显示文摘Background:There is an ongoing debate on the feasibility,safety,and oncological efficacy of the associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)technique.The aim of this study was to compare ALPPS,two-staged hepatectomy(TSH),and portal vein embolization(PVE)/ligation(PVL)using updated traditional meta-analysis and network meta-analysis(NMA).Data sources:Electronic databases were used in a systematic literature search.Updated traditional metaanalysis and NMA were performed and compared.Mortality and major morbidity were selected as primary outcomes.Results:Nineteen studies including 1200 patients were selected from the pool of 436 studies.Of these patients,315(31%)and 702(69%)underwent ALPPS and portal vein occlusion(PVO),respectively.Ninetyday mortality based on updated traditional meta-analysis,subgroup analysis of the randomized controlled trials(RCTs),and both Bayesian and frequentist NMA did not demonstrate significant differences between the ALPPS cohort and the PVE,PVL,and TSH cohorts.Moreover,analysis of RCTs did not demonstrate significant differences of major morbidity between the ALPPS and PVO cohorts.The ALPPS cohort demonstrated significantly more favorable outcomes in hypertrophy parameters,time to operation,definitive hepatectomy,and R0 margins rates compared with the PVO cohort.In contrast,1-year disease-free survival was significantly higher in the PVO cohort compared to the ALPPS cohort.Conclusions:This study is the first to use updated traditional meta-analysis and both Bayesian and frequentist NMA and demonstrated no significant differences in 90-day mortality between the ALPPS and other hepatic hypertrophy approaches.Furthermore,two high quality RCTs including 147 patients demonstrated no significant differences in major morbidity between the ALPPS and PVO cohorts. | Paschalis Gavriilidis Robert P Sutcliffe Keith J Roberts Madhava Pai Duncan Spalding Nagy Habib Long R Jiao Mikael H Sodergren | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，5： | 6 |
| 2 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 3 | Polymer-drug conjugates,PDEPT and PELT:basic principles for design and transfer from the laboratory to clinic 显示文摘 | Duncan R Gac-Breton S Keane R | 2001 | J Controlled Release2001，74，13： | 2 |
| 4 | Proline accumulaion and its implication incold tolerance of regenerable maize callus显示文摘 | DUNCAN D R Widho W | 1987 | Plant Physiol1987，83，： | 1 |
| 5 | Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterolfed mice显示文摘 | Maxwell K Soccio R Duncan E | 2003 | J Lipid Res2003，44，11： | 1 |
| 6 | The solar X-ray imaget for GOES显示文摘 | Lemen J R Duncan D Edwards C | 2004 | SPIE2004，5171，： | 1 |
| 7 | Heterologous protein secre- tion from yeast显示文摘 | Smith R A Duncan M J Moir D T | 1985 | Science1985，20，： | 1 |
| 8 | Application of commercial microwave ovens to organic synthesis 显示文摘 | Giguere R J Bray T L Duncan S M | 1986 | Tetrahedron Letter press1986，27，41： | 1 |
| 9 | Wear tolerance,shoot performance and spectral reflectance of seashore paspalum and Bermudagrass显示文摘 | Trenholm L E Duncan R R Carrow R N | 1999 | Crop Science1999，39，： | 1 |
| 10 | Identification of factor inhibitors by diagnostic haemostasis laboratories;a large multi-centre evaluation显示文摘 | Favaloro EJ Bonar R Duncan E | | 0，，： | 1 |
| 11 | Polymer conjugates as anticancer nanomedicines显示文摘 | Duncan R | 2006 | Nature Review Cancer2006，6，9： | 1 |
| 12 | Late onset psychogenic nonepileptic attacks 显示文摘 | Duncan R Oto M Martin E | 2006 | Neurology2006，66，11： | 1 |
| 13 | Effect of intra- gastric pH on mucosal protective action of sucralfate 显示文摘 | DANESH B J DUNCAN A RUSSELL R I | 1988 | Gut1988，29，10： | 1 |
| 14 | Osmotic induced stimulation of the reduction of the viability dye 2,3,5 triphenyltetrazolium chlo ride by maize roots and callus cultures 显示文摘 | Duncan D R Widholm J M | 2004 | Journal of Plant Physiology2004，161，： | 1 |
| 15 | The creation of momentum for change through the process of strategic issue diagnosis显示文摘 | Duncan R | 1987 | Strategic Management Journal1987，8，： | 1 |
| 16 | Web space reconstruction with a M-V flap显示文摘 | LEWIS R C NORDYKE M D DUNCAN K H | 1988 | J Hand Surg Am1988，13，1： | 1 |
| 17 | The dawning era of polymer therapeutics 显示文摘 | DUNCAN R | 2003 | Nat Rev Drug Discov2003，2，5： | 1 |
| 18 | Transit ' s value-added effects: light and commuter rail services and commercial land values 显示文摘 | CERVERO R DUNCAN M | | Transportation Research Record: Journal of the Transportation Research Board0，18，5： | 1 |
| 19 | Pro- duction and response of human prostate cancer cell lines to granulocyte macrophage-eolony stimulating factor显示文摘 | Lang S H Miller W R Duncan W Habib F K | 1994 | Int J Cancer1994，59，： | 1 |
| 20 | Application of commercial microwave ovens to organic synthesis显示文摘 | Giguere R J Bray T L Duncan S M | 1986 | Tetrahedron Letters1986，27，41： | 1 |
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