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| 1 | Endoscopic resection techniques for colorectal neoplasia:Current developments显示文摘Endoscopic polypectomy and endoscopic mucosal resection(EMR) are the established treatment standards for colorectal polyps. Current research aims at the reduction of both complication and recurrence rates as well as on shortening procedure times. Cold snare resection is the emerging standard for the treatment of smaller(< 5 mm) polyps and is possibly also suitable for the removal of noncancerous polyps up to 9 mm. The method avoids thermal damage, has reduced procedure times and probably also a lower risk for delayed bleeding. On the other end of the treatment spectrum, endoscopic submucosal dissection(ESD)offers en bloc resection of larger flat or sessile lesions. The technique has obvious advantages in the treatment of high-grade dysplasia and early cancer. Due to its minimal recurrence rate, it may also be an alternative to fractionated EMR of larger flat or sessile lesions. However, ESD is technically demanding and burdened by longer procedure times and higher costs. It should therefore be restricted to lesions suspicious for high-grade dysplasia or early invasive cancer.The latest addition to endoscopic resection techniques is endoscopic fullthickness resection with specifically developed devices for flexible endoscopy.This method is very useful for the treatment of smaller difficult-to-resect lesions,e.g., recurrence with scar formation after previous endoscopic resections. | Franz Ludwig Dumoulin Ralf Hildenbrand | 2019 | World Journal of Gastroenterology2019，25，3： | 35 |
| 2 | Endoscopic mucosal resection of colorectal adenomas > 20 mm: Risk factors for recurrence显示文摘AIM: To evaluate risk factors for local recurrence after endoscopic mucosal resection of colorectal adenomas > 20 mm.METHODS: Retrospective data analysis of 216 endoscopic mucosal resections for colorectal adenomas > 20 mm in 179 patients(40.3% female; median age 68 years; range 35-91 years). All patients had at least 1 follow-up endoscopy with a minimum control interval of 2 mo(mean follow-up 6 mo/2.0-43.4 mo). Possible factors associated with local recurrence were analyzed by univariate and multivariate analysis. RESULTS: Median size of the lesions was 30 mm(20-70 mm),69.0% were localized in the right-sided(cecum,ascending and transverse) colon. Most of the lesions(85.6%) showed a non-pedunculated morphology and the majority of resections was in piecemeal technique(78.7%). Histology showed carcinoma or high-grade intraepithelial neoplasia in 51/216(23.6%) lesions including 4 low risk carcinomas(pT1 a,L0,V0,R0- G1/G2). Histologically proven recurrence was observed in 33/216 patients(15.3%). Patient age>65 years,polyp size>30 mm,non-pedunculated morphology,localization in the right-sided colon,piecemeal resection and tubular-villous histology were found as associated factors in univariate analysis. On multivariate analysis,only localization in the rightsided colon(HR = 6.842/95%CI:1.540-30.394; P=0.011),tubular-villous histology(HR = 3.713/95%CI: 1.617-8.528;P=0.002) and polyp size>30 mm(HR=2.563/95%CI:1.179-5.570; P=0.017) were significantly associated risk factors for adenoma recurrence. CONCLUSION: Meticulous endoscopic follow-up is warranted after endoscopic mucosal resection of adenomas localized in the right-sided colon larger than > 30 mm,with tubular-villous histology. | Alexander Briedigkeit Omar Sultanie Bernd Sido Franz Ludwig Dumoulin | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，5： | 6 |
| 3 | C-reactive protein is a prognostic indicator in patients with perihilar cholangiocarcinoma显示文摘AIM: To evaluate prognostic indicators for the outcome of patients with perihilar extrahepatic cholangiocarcinoma in an unselected cohort. METHODS: We retrospectively analyzed 98 patients with perihilar cholangiocarcinoma. Twenty-three patients (23.5%) underwent tumor resection. Patients with non- resectable tumors underwent either transpapillary or percutaneous transhepatic biliary drainage. Additionally, 32 patients (32.7%) received photodynamic therapy (PDT) and 18 patients (18.4%) systemic chemotherapy. Predefined variables at the time of diagnosis and characteristics considering the mode of treatment were entered into a Cox’s proportional hazards model. Included in the analysis were age, tumor stage following the modified Bismuth-Corlette classification, bilirubin, prothrombin time (PT), C-reactive protein (CRP), carbohydrate antigen 19-9 (CA19-9), history of weight loss, surgical resection, chemotherapy and PDT. RESULTS: The Kaplan-Meier estimate of overall median survival was 10.5 (95%CI: 8.4-12.6) mo. In the univariate analysis, low Bismuth stage, low CRP and surgical resection correlated significantly with better survival. In the multivariate analysis, only CRP (P = 0.005) and surgical resection (P = 0.029) were found to be independently predictive of survival in the cohort. Receiver operating characteristic (ROC) analysis identified a CRP level of 11.75 mg/L as the value associated with the highest sensitivity and specificity predicting a survival > 5 mo. Applying Kaplan-Meier analysis, patients with a CRP < 12 mg/L at the time of diagnosis had a signifi cantly longer median survival than patients with higher values (16.2 vs 7.6 mo; P = 0.009).CONCLUSION: This retrospective analysis identif ied CRP level at the time of diagnosis as a novel indicator for the prognosis of patients with perihilar cholangiocarcinoma. It should be evaluated in future prospective trials on this entity. | Thomas Gerhardt Sabine Milz Michael Schepke Georg Feldmann Martin Wolff Tilman Sauerbruch Franz Ludwig Dumoulin | 2006 | World Journal of Gastroenterology2006，12，34： | 5 |
| 4 | N-alkylamide profiling of Achillea ptarmica and Achillea millefolium extracts by liquid and gas chromatography–mass spectrometry显示文摘Achillea millefolium and Achillea ptarmica are both plants belonging to the Asteracea family and are traditionally used for their medicinal properties. It has already been shown that some N-alkylamides(NAAs)are responsible for these pharmacological actions. Therefore, in the present study, the NAA content of the two plants was analytically characterised. Different extracts were prepared from the roots, the leaves, the stems and the flowers. The structures of NAAs have been assigned in ethanolic extracts of Achillea millefolium and Achillea ptarmica using high performance liquid chromatography – electrospray ionisation – mass spectrometry(HPLC–ESI–MS) and gas chromatography – electron impact – mass spectrometry(GC–EI–MS). Using both analytical techniques, the structures of 14 and 15 NAAs have been assigned in Achillea ptarmica and Achillea millefolium, respectively. Structures of two new NAAs, previously never observed in Achillea ptarmica,were assigned: deca-2E,6Z,8E-trienoic acid 2-methylbutylamide(homospilanthol) or a related isomeric compound and deca-2E,4E-dienoic acid N-methyl isobutylamide. The structure of homospilanthol or a related isomeric compound was also assigned in Achillea millefolium for the first time. | Lieselotte Veryser Lien Taevernier Evelien Wynendaele Yannick Verheust Ann Dumoulin Bart De Spiegeleer | 2017 | Journal of Pharmaceutical Analysis2017，7，1： | 3 |
| 5 | Urinary incontinence after stroke:identification,assessment,and intervention by rehabilitation professionals in Canada显示文摘 | Dumoulin C Korner-Bitensky N Tannenbaum C | 2007 | Stroke2007，38，10： | 1 |
| 6 | Convective destabilization of a thickened continental lithosphere显示文摘 | Morency C Doin M P Dumoulin C | 2002 | Earth and Planetary Science Letters2002，202，： | 1 |
| 7 | Colorresponsesofthehumanlateralgeniculatenucleus:selectiveamplification ofSconesignalsbetweenthelateralgeniculatenucleusandpri-maryvisualcortexmeasuredwithhigh-fieldfMRI显示文摘 | Mullen K T DumoulinS HessR F | 2008 | EurJNeu-rosci2008，28，9： | 1 |
| 8 | Single-domain antibody fragments with high conformational stability显示文摘 | Dumoulin M Conrath K Van Meirhaeghe A | 2002 | Protein Sci2002，11，3： | 1 |
| 9 | Pelvic floor muscle training versus no treatment, or inactive control treatments,for urinary incontinence in women:a short version Conchrane systematic review with meta-analysis显示文摘 | Dumoulin C Hay-Smish J Hab6e-S6guin G M | 2015 | Neurourol Urodyn2015，34，4： | 1 |
| 10 | Probing the origins diagnosis and treatment of amyloid diseases using antibodies显示文摘 | Dumoulin M Dobson C M | 2004 | Biochimie2004，86，910： | 1 |
| 11 | MR guided percutaneous angioplasty: assessment of tracking safety, catheter handling and functionality显示文摘 | Wildermuth S Dumoulin CL Pammatter T | 1998 | Cardiovasc Intervent Radiol1998，21，2： | 1 |
| 12 | Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors显示文摘 | Egli A Infanti L Dumoulin A | 2009 | J Infect Dis2009，199，6： | 1 |
| 13 | Particles agglomeration in a conical fluidized bed in relation with air temperature profiles显示文摘 | Jimenez T Turchiuli C Dumoulin E | 2006 | Chemical Engineering Science2006，61，18： | 1 |
| 14 | Long term costs and effects of reducing the number of twin pregnan- cies in IVF by single embryo transfer: the TwinSing study 显示文摘 | Van Heesch MM Bonsel GJ Dumoulin JC | 2010 | BMC Pediatr2010，10，： | 1 |
| 15 | Calcitionin gene-related peptide and peripheral nerve regeneration显示文摘 | Dumoulin F L Raivich G Hass C A | 1992 | Ann NY A cad Sci1992，，657： | 1 |
| 16 | MR-guided percutaneous angioplasty:assessment of tracking safety,catheter handling and functionality显示文摘 | Wildermuth S Dumoulin CL Pammatter T | 1998 | Cardiovasc Intervent Radiol1998，21，2： | 1 |
| 17 | A set of highly water-soluble tetraethyleneglycol-substituted Zn(II) phthalocyanines- synthesis, photochemical and photophysical properties, interaction with plasma proteins and in vitro phototoxicity 显示文摘 | TUNCEL S DUMOULIN F GAILER J | 2011 | Dalton Trans2011，40，16： | 1 |
| 18 | Peptide YY, gluca gon-like peptide-1, and neurotensin responses to luminal factors in the isolated vascularly perfused rat ileum显示文摘 | Dumoulin V Moro F Barcelo A | 1998 | Endocrinology1998，139，9： | 1 |
| 19 | Early cleavage is a valuable addition to existing embryo selection parameters:a study using single embryo transfers显示文摘 | Van Montfoort A P Dumoulin J C Kester A D | 2004 | Hum Reprod2004，19，9： | 1 |
| 20 | Flavor encapsulation by spray drying: applition to citral and linaly acetate显示文摘 | Bhandari B R Dumoulin E D Richard H M J | 1992 | J Food Sci1992，，1： | 1 |
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