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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | 基因对于儿童肥胖的影响在小于胎龄儿童中或不重要显示文摘小于胎龄儿在日后的生活中面临着更高的患肥胖症和代谢性疾病的风险,目前认为这种风险主要与小于胎龄儿出生后生长加速有关。研究人员对奥克兰出生体重协作研究项目中的小于胎龄儿和适于胎龄儿做了研究,测量并计算这些儿童的BMI-Z评分,研究与成人肥胖相关的常见基因变异是否会与小于胎龄儿出生后生长加速有关。研究者将547名欧洲儿童(228名小于胎龄儿和319名适于胎龄儿)进行基因分型,他们被分为共计37个单核苷酸多态性(SNPs)候选基因。重复测量儿童的BMI,并以Z评分法评估肥胖程度。 | Dug Yeo Han Rinki Murphy Angharad R Morgan 郭婧 张帆 | 2013 | 营养健康新观察2013，0，1： | 2 |
| 3 | Role of β-microseminoprotein from prostate cancer initiationto recurrence: A mini-review显示文摘Medline/Pubmed articles relevant to this topic were considered using the search terms ?-microseminoprotein, MSMB, prostate secretory protein of 94 amino acids and PSP94. Full articles were retrieved when the abstract was considered relevant. In addition, other data related to this topic including our own are discussed. Summary of fi ndings-?-microseminoprotein(MSMB) is increasingly being considered as a marker for prostatecancer, as reduced levels have been associated with the disease. Here we review various aspects of this protein including its biological and physiological variants, binding proteins and immune modulation; its importance as a marker for biochemical recurrence of prostate cancer; prostate cancer related splice variants and its therapeutic utility. Two of the most important properties of MSMB are related to anticancer functions and immune modulation. Predominant expression of two(short and full-length) splice variants of MSMB has been observed from normal prostate and several other tissues. In benign prostate hyperplasia the short isoform is dominant, constituting 98% of this isoform, whereas in prostate cancer 96% constitute the fulllength isoform. The MSMB promoter single nucleotide polymorphism rs10993994 with the C allele functions as an activated cyclic adenosine monophosphate response element binding protein binding site. This C variant of rs10993994 could be responsible for the production of splice variants under variable conditions. MSMB has binding motifs to a few known proteins including immunoglobulin G and several Cysteine-rich secretory proteins family proteins. MSMB bound to these proteins is considered as immune modulating. Use of MSMB as a urinary marker for detecting aggressive prostate cancers that could resist radiation and surgical treatments, seems possible, but needs further investigation. The ratio of MSMB splice variants could also be a possible approach in understanding prostate cancers, with higher ratios indicating severe disease. | Nishi Karunasinghe Karen Bishop Pamela Murray Yuanye Xu Megan Goudie Lance Ng Shuotun Zhu Dug Yeo Han Lynnette R Ferguson Jonathan Masters Benji Benjamin Michael Holmes | 2014 | World Journal of Clinical Urology2014，3，1： | 2 |
| 4 | Preparation and structure analysis of titanium oxide nanotubes显示文摘 | DUG H CHEN Q CHE R C | 2001 | Appl Phys Lett2001，39，22： | 1 |
| 5 | Modulatory effects of compound polysaccharide erweikang on the immune function of mice 显示文摘 | DuG MaB Zhang R etal | 2002 | J Huazhong Univ Sci Technolog Med Sci2002，22，3： | 1 |
| 6 | Antioxidant capacity and the relation-ship with polyphenol and vitaminC in Actinidia fruits 显示文摘 | DUG R LI M J MA F W | 2009 | Food Chemistry2009，113，： | 1 |
| 7 | Surface phenomena in the process of vanadium hydride formation显示文摘 | Dug R Nowicka E Wolfram Z | 1997 | Journal of Alloys and Compounds1997，，： | 1 |
| 8 | Dissociating intentional learning from relative novelty responses in the medial temporal lobe 显示文摘 | Strang B'A Hurlemann R Dug gins A | 2005 | Neuroimage2005，25，： | 1 |
| 9 | Discharge Coeffcients for Incompressible Non-Cavitating Flow Through Long Orifces显示文摘 | Dug gins R K Markland | 1965 | Journal of Mechanical Engineering Science1965，7，2： | 1 |
| 10 | Acoustic radiation force on a small compressible sphere in a focused beam显示文摘 | WU J R DUG H | 1990 | Journal of the Acoustical Society America1990，87，3： | 1 |
| 11 | Surface Phenomena in the Process of Vanadium Hydride Formation 显示文摘 | DUG R NOWICKA E WOLFAM Z | 1997 | Journal of Alloys and Compunds1997，，： | 1 |
| 12 | Rapid determination of four tobacco specific nitrosamines in burley tobacco by near-infrared spectroscopy显示文摘 | MAY J BAI R S DUG R | 2012 | Anal Mehods2012，，4： | 1 |
| 13 | Acoustic radiation force on a small compressible sphere in a focused beam显示文摘 | WU J R DUG H | | 0，，03： | 1 |
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