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| 1 | Effects of alkaline-electrolyzed and hydrogen-rich water,in a high-fat-diet nonalcoholic fatty liver disease mouse model显示文摘AIM To identify the effect of hydrogen-rich water(HRW) and electrolyzed-alkaline water(EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.METHODS Mice were divided into four groups:(1) Regular diet(RD)/regular water(RW);(2) high-fat diet(HFD)/RW;(3) RD/EAW; and(4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen(H2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.RESULTS EAW had several properties important to the study:(1) pH = 11;(2) oxidation-reduction potential of-495 mV; and(3) H2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations(L-HRW = 0.3 mg H2/L and H-HRW = 0.8 mg H2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass(46% vs 61%), an increase in lean body mass(42% vs 28%), and a decrease in hepatic lipid accumulation(P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.CONCLUSION H2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice. | Karen Jackson Noa Dressler Rotem S Ben-Shushan Ari Meerson Tyler W LeBaron Snait Tamir | 2018 | World Journal of Gastroenterology2018，24，45： | 9 |
| 2 | A siliconboron carbonitride ceramic stable to 2 000℃ 显示文摘 | RIEDEL R KIENZLE A DRESSLER W | 1996 | Nature1996，382，： | 1 |
| 3 | A siliconboron carbonitride ceramic stable to 2 000 ℃显示文摘 | Riedel R Kienzle A Dressler W | 1996 | Nature1996，382，： | 1 |
| 4 | First Measurement of a Thermochemical Property of a Seaborgium Compound显示文摘 | Turler A Bruchle W Dressler R | 1999 | Angew Chem Int Ed1999，38，： | 1 |
| 5 | Phase quantification of ct-SiaN4/-SiC mixtures by X-ray powder diffraction analysis显示文摘 | Nicolieh J P Lences Z Dressler W | 2000 | Journal of Materials Science2000，35，： | 1 |
| 6 | A Silicoboron carbonitride ceramic stable to 2000℃显示文摘 | RIDEL R KIENZLE A DRESSLER W | 1996 | Nature1996，382，： | 1 |
| 7 | A silicoboron carbonitride ceramic stable to 2,000℃ 显示文摘 | Riedel R Kienzle A Dressler W | 1996 | Nature1996，382，6594： | 1 |
| 8 | Dielectric breakdown of the erythrocyte membrane enhances transbilayer mobility of phospholipids显示文摘 | DRESSLER V SCHWISTER K HAEST C W | 1983 | Biochim Biophys Acta1983，732，1： | 1 |
| 9 | A Silicoboron carbonitride ceramic stable to 2 000 ℃显示文摘 | RIEDEL R KIENZLE A DRESSLER W | | 0，，6594： | 1 |
| 10 | 现代柴油机新型预热系统显示文摘介绍为了进一步改善柴油机的起动性能、运行平稳性和废气排放,并保证柴油机即时起动,Robert Bosch公司开发的一种新的预热系统。它包括复合陶瓷护套式预热塞以及晶体管预热控制器。由于它用外部加热装置加热的新原理以及预热塞温度很高,复合陶瓷护套式预热塞与普通陶瓷和金属预热塞相比具有许多值得重视的优势。 | Kern C Dressler W Lindemann G 王蕴玉 | 2000 | 国外内燃机2000，，4： | 1 |
| 11 | A siliconboron carbonitride ceramic stable to 2000℃显示文摘 | Riedel R Kienzle A Dressler W | | 0，，： | 1 |
| 12 | Swidden transformations and rural livelihoods in Southeast Asia显示文摘 | CRAMB R A PIERCE COLFER C J DRESSLER W | 2009 | Hum Ecol2009，37，： | 1 |
| 13 | Phase quantification of β-Si3N4/β-SiC mixtures by X-ray powder diffraction analysis 显示文摘 | NICOLICH J P LENCES Z DRESSLER W | 2000 | Journal of Materials Science2000，35，6： | 1 |
| 14 | Role of steroid hormone receptors as prognostic factors in primary breast cancer 显示文摘 | McGuire W L Clark G M Dressler L G | 1986 | NCIMonogr1986，，1： | 1 |
| 15 | Heavy metals in cottontail rabbits on mined lands treated with sewage sludge显示文摘 | Dressler R L Strom G L Tzilkowski M W | 1986 | Journal of Environmental Quality1986，15，3： | 1 |
| 16 | A Siliconboron Carbonitride Ceramic Stable to 2 000 ℃显示文摘 | Riedel R Kienzle A Dressler W | | 0，，29： | 1 |
| 17 | A silicobo- ron carbonitride ceramic stable to 2 000 ℃ 显示文摘 | RIEDEL R KIENZLE A DRESSLER W | 1996 | Nature1996，382，6594： | 1 |
| 18 | Chemical Characterization of Bohrium (Element 107) 显示文摘 | Eichler R Bruchle W Dressler R | 2000 | Na- ture2000，407，： | 1 |
| 19 | Chemical formation of ceramies显示文摘 | RIEDEL R DRESSLER W | 1996 | Ceramics International1996，22，： | 1 |
| 20 | Chemical Investigation of Hassium (Element 108)显示文摘 | Dullmann C Bruchle W Dressler R | 2002 | Nature2002，418，： | 1 |
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