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| 1 | Paeoniflorin suppresses TGF-β mediated epithelial- mesenchymal transition in pulmonary fibrosis through a Smad-dependent pathway显示文摘 | Yu JI Yan-nong DOU Qian-wen ZHAO Ji-zhou ZHANG Yan YANG Ting WANG Yu-feng XIA Yue DAI Zhi-feng WEI | 2016 | Acta Pharmacologica Sinica2016，37，6： | 48 |
| 2 | A systematic analysis of pneumatosis cystoids intestinalis显示文摘AIM:To increase the understanding,diagnosis and treatment of pneumatosis cystoides intestinalis(PCI)and to find the characteristics and potential cause of the disease in China.METHODS:We report here one case of PCI in a 70-year-old male patient who received a variety of treatment methods.Then,we systematically searched the PCI eligible literature published from an available Chinese database from May 2002 to May 2012,including CBM,CBMDisc,CMCC,VIP,Wanfang,and CNKI.The key words were pneumatosis cystoides intestinalis,pneumatosis,pneumatosis intestinalis,pneumatosis coli and mucosal gas.The patients' information,histories,therapies,courses,and outcomes were reviewed.RESULTS:The study group consisted of 239 PCI cases(male:female = 2.4:1)from 77 reported incidents.The mean age was 45.3 ± 15.6 years,and the median illness course was 6 mo.One hundred and sixty patients(66.9%)were in high altitude areas.In addition,43.5%(104/239)of the patients had potential PCI-related disease,and 16.3% had complications with intestinal obstruction and perforation.The most common symptom was abdominal pain(53.9%),followed by diarrhea(53.0%),distention(42.4%),nausea and vomiting(14.3%),bloody stool(12.9%),mucous stool(12.0%)and constipation(7.8%).Most multiple pneumocysts developed in the submucosa of the colon(69.9%).The efficacy of the treatments by combined modalities,surgery,endoscopic treatment,conservative approach,oxygen,and antibiotics were 100%,100%,100%,93.3%,68.3% and 26.3%,respectively.CONCLUSION:PCI can be safely managed by conservative treatments,presents more frequently in males,in the large bowel and submucosa,than in females,in the small intestine and subserosa.High altitude residence maybe associated with the PCI etiology. | Li-Li Wu Yun-Sheng Yang Yan Dou Qing-Sen Liu | 2013 | World Journal of Gastroenterology2013，19，30： | 27 |
| 3 | Determining "abnormal" levator hiatus distensibility using three-dimensional transperineal ultrasound in Chinese women显示文摘The dimension of the levator hiatus is a possible predictor of pelvic organ prolapse (POP). Thisretrospective study investigated 360 women who went to urogynecological clinic for pelvic floor discomfort.Levator hiatus dimensions were obtained by three-dimensional transperineal ultrasound and results werecompared between women with and without significantly objective prolapse (International Continence SocietyPOP quantification, grade 2 or higher). Receiver operating characteristic (ROC) curve analyses were performed todetermine valid screening index for detecting abnormal levator hiatus distensibility. Women with significantlyobjective prolapse had significantly higher levator hiatus dimensions than those without (all P 〈 0.001). ROCcurve analyses confirmed that hiatal area (HA) of 19.5 cm2 during Valsalva maneuver can be used as single-screening index for abnormal levator hiatus distensibility with sensitivity of 0.80 and specificity of 0.70. In thisstudy, we used a two-step method and achieved higher sensibility (0.80 vs. 0.87) without reducing specificity (0.70vs. 0.71) compared with a single-screening index method. As a result, we suggest that HA ≥ 19.5 cm2 duringValsalva maneuver is an indicator of abnormal levator hiatus distensibility in Chinese women and that the two-step method has higher sensitivity in detecting abnormal distensibility. | Chaoran Dou Qin Li Tao Ying Yulin Yan Xia Wang Bing Hu | 2018 | Frontiers of Medicine2018，12，5： | 21 |
| 4 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 5 | Antidepressant effect of Xingnao Jieyu decoction mediated by alleviating neuroinflammation in a rat model of post-stroke depression显示文摘OBJECTIVE: To identify the antidepressant effect of Xingnao Jieyu (XNJY) decoction on a post-stroke depression (PSD) rat model and the underlying molecular mechanism. METHODS: We established a rat PSD model by middle cerebral artery occlusion (MCAO) combined with chronic unpredictable mild stress (CUMS). Healthy SD rats were randomly divided into six groups: sham, PSD, fluoxetine (Flu), and XNJY groups at low, middle, and high doses. The sham group underwent sham operation, while the other groups underwent MCAO+CUMS. The Flu and XNJY decoction groups were intragastrically administered with Flu or different doses of XNJY for 21 consecutive days. Histopathological changes in the cortex and hippocampus were observed by staining with hematoxylin and eosin and Terminal-deoxynucleoitidyl Transferase Mediated Nick End Labeling. Iba1 positive cells were evaluated by immunofluorescence assay. The expressions of tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), interleukin-1β(IL-1β), 5-hydroxytryptamine (5-HT), and norepinephrine (NE) in the cortex and hippocampus were measured by enzyme linked immunosorbent assay. RESULTS: The PSD group rats had a significant decrease in body weight, consumption of sucrose water, and locomotor activity but an increase in immobility time during a forced swimming test (P < 0.01) compared with sham group. Flu and different doses of XNJY significantly recovered these indices (P < 0.01). XNJY also inhibited neuronal damage and apoptosis in the cortex induced by PSD (P < 0.01). Furthermore, XNJY reduced the number of Iba1 positive cells and the expressions of TNF-α, IL-6, and IL-1β, in addition to recovered the levels of 5-HT and NE in the cortex and hippocampus (P < 0.01). CONCLUSION: The alleviation of neuroinflammation might be an important mechanism of the XNJY decoction against PSD. Thus, XNJY might be a promising candidate for the treatment of PSD. | Yan Yongmei Li Tao Wang Dou Zhao Bingbing Zhou Qi | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 11 |
| 6 | Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing,China,in 2016:Is It Relevant?显示文摘Objective The aim of this study is to investigate the macrolide resistance rate and molecular type with multiple-locus variable-number tandem-repeat analysis(MLVA)of Mycoplasma pneumoniae of Beijing in 2016 in pediatric patients.Methods Real-time quantitative polymerase chain reaction(PCR)was used to identify M.pneumoniae,and MLVA was performed.The domain V of the 23 S rRNA was sequenced to detect macrolide-resistant point mutations.We also investigated the activities of antibiotics against M.pneumoniae isolates in vitro.Results The PCR detection rate of M.pneumoniae in children in Beijing was 40%,and the macrolide resistance rate was 66%.The A2063 G mutation in the 23 S rRNA V region is the dominant mutation(137/146,93.84%),whereas the A2064 G mutation is rare(9/146,6.16%).Seventy-three samples were typed successfully by MLVA typing,including 86.3%(63/73)were MLVA type 4-5-7-2,and 13.7%(10/73)were MLVA type 3-5-6-2.No other types were found.No strains were resistant to levofloxacin or tetracycline.Conclusion In 2016,a specific decrease in the macrolide resistance rate occurred in Beijing.The detection rate and macrolide resistance rate of outpatients are lower than those of inpatients.The A2063 G mutants M.pneumoniae have high levels of resistance to erythromycin and azithromycin.The primary MLVA type is 4-5-7-2,followed by 3-5-6-2.No other MLVA types were detected.No strains resistant to tetracycline or levofloxacin were found in vitro. | DOU Hai Wei TIAN Xiu Jun XIN De Li WEI Ran ZHOU Wei WANG Hong QIN Xuan Guang SHAO Jun Yan XU Bao Ping GE Li Xia SHI Da Wei | 2020 | Biomedical and Environmental Sciences2020，33，12： | 9 |
| 7 | Classification of microseismic events in high stress zone显示文摘For the purpose of having a better understanding of failure mechanisms of rock fracturing in mines, the equivalent point source models of tensile, shear and explosive seismic events were established, and the relationship between far-field seismic displacements of the waves and the corresponding equivalent forces were analyzed as well. Based on the results of a microseismic monitoring carried out in the mining progress of 9202 working face under the upper remnant coal pillar in Sanhejian Mine, the waveform features of the seismic events associated with different failure modes were further analyzed. The results show that the signals corresponding to different failure mechanisms have different radiation patterns of the seismic displacements, and different characteristics in waveform features, such as dominant frequency, energy released, the ratio of S- to P-wave energy, and so on. In addition, the rock burst happened in the high stress zone is mainly the result of the strong shear fracturing in the mining process. The results of this study have significantly improved the understanding of the characteristics of the failures associated with underground mining, and will greatly benefit the prevention and control of rock burst hazards in burst-prone mines. | CAO An-ye DOU Lin-ming YAN Ru-ling JIANG Heng LU Cai-ping DU Tao-tao LU Zhen-yu | 2009 | Mining Science and Technology2009，19，6： | 9 |
| 8 | Clinical and Angiographic Predictors of Major Side Branch Occlusion after Main Vessel Stenting in Coronary Bifurcation Lesions显示文摘 | Dong Zhang Bo Xu Dong Yin Yi-Ping Li Yuan He Shi-Jie You Shu-Bin Qiao Yong-Jian Wu Hong-Bing Yan Yue-Jin Yang Run-Lin Gao Ke-Fei Dou | 2015 | Chinese Medical Journal2015，，11： | 8 |
| 9 | Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin显示文摘 | Xia Ding Feng Yan Phil Yao Zhihong Yang Weihong Wan Xiwei Wang Jing Liu Xinjiao Gao Ariane Abrieu Tongge Zhu Jiancun Zhang Zhen Dou Xuebiao Yao | 2010 | Cell Research2010，20，12： | 8 |
| 10 | Detecting prostate cancer and prostatic calcifications using advanced magnetic resonance imaging显示文摘前列腺癌症和 prostatic 石灰化在老人有高发生。我们试图在检测前列腺癌症和 prostatic 石灰化调查危险性加权的成像的诊断能力。156 个人的一个全部的数字,与前列腺癌症包括 34 并且 122 在这研究与良性的前列腺被注册。计算断层摄影术,常规磁性的回声成像,散开加权的成像,和危险性加权的成像在所有病人上被执行。112 prostatic 石灰化在 87 个病人被检测。常规磁性的回声成像,明显的散开系数,和在检测前列腺癌症和 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性是计算的。McNemars Chi 平方测试被用来在在这些技术之间的敏感和特性比较差别。结果证明在检测 prostatic 癌症的过滤危险性的阶段图象的敏感和特性比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。另外,在检测 prostatic 石灰化的过滤危险性的阶段图象的敏感和特性比得上计算断层摄影术的并且比常规磁性的回声成像和明显的散开系数的大(P < 0.05 ) 。在前列腺癌症给危险性加权的成像(SWI ) 的高发生反常,我们断定危险性加权的成像在检测前列腺癌症比常规磁性的回声成像,散开加权的成像,和计算断层摄影术更敏感、特定。而且,危险性加权的成像能识别类似于计算断层摄影术的 prostatic 石灰化,并且它比常规磁性的回声成像和散开加权的成像好一些。 | Shewei Dou Yan Bai Ankit Shandil Degang Ding Dapeng Shi E Mark Haacke Meiyun Wang | 2017 | Asian Journal of Andrology2017，19，4： | 7 |
| 11 | Bone Metabolic Markers in Patients with Obstructive Sleep Apnea Syndrome显示文摘 | Yan Qiao Bei Wang Jiao-Jiao Yang Yan-Feng Fan Qian GUO Zhan-Jun Dou Ya-Qiong Huang Ting-Ting Feng Shu-Juan Wang Dong-Dong An Xiao-Ling Gao | 2018 | Chinese Medical Journal2018，，16： | 7 |
| 12 | Modal identification based on Hilbert-Huang Transform of structural response with S VD preprocessing显示文摘In recent years, Empirical mode decompositionand Hilbert spectral analysis have been combined to identifysystem parameters. Singular-Value Decomposition is proposedas a signal preprocessing technique of Hilbert-HuangTransform to extract modal parameters for closely spacedmodes and low-energy components. The proposed methodis applied to a simulated airplane model built in AutomaticDynamic Analysis of Mechanical Systems software. Theresults demonstrate that the identified modal parameters arein good agreement with the baseline model. | Min Zheng Fan Shen Yuping Dou Xiaoyan Yan College of Civil Aviation,Nanjing University of Aeronautics and Astronautics,210016 Nanjing. China | 2009 | Acta Mechanica Sinica2009，25，6： | 7 |
| 13 | Absorption mechanism of carbon-nanotube paper- titanium dioxide as a multifunctional barrier material for lithium-sulfur batteries显示文摘Lithium-sulfur batteries attract much interest as energy storage devices for their low cost, high specific capacity, and energy density. However, the insulating properties of sulfur and high solubility of lithium polysulfides decrease the utilization of active materials by the battery resulting in poor cycling performance. Herein, we design a multifunctional carbon-nanotube paper/titanium-dioxide barrier which effectively reduces active material loss and suppresses the diffusion of lithium polysulfides to the anode, thereby improving the cycling stability of lithium-sulfur batteries. Using this barrier, an activated carbon/sulfur cathode with 70% sulfur content delivers stable cycling performance and high Coulombic efficiency (-99%) over 250 cycles at a current rate of 0.5 C. The improved electrochemical performance is attributed to the synergistic effects of the carbon nanotube paper and titanium dioxide, involving the physical barrier, chemical adsorption from the binding formation of Ti-S and S-O, and other interactions unique to the titanium dioxide and sulfur species. | Guiyin Xu Jiaren Yuan Xinyong Tao Bing Ding Hui Dou Xiaohong Yan Yang xiao Xiaogang Zhang | 2015 | Nano Research2015，8，9： | 7 |
| 14 | A New Cyclic Peptide from Schnabelia tetradonta显示文摘A new cyclic octapeptide (schnabepeptide B) was isolated from the aerial part ofSchnabelia tetradonta (Sun) C. Y. Wu et C. Chen (Lamiaceae). Its structure was elucidated ascyclo-(NH-Trp-Gly1-Leu1-Gly2-Pro1-Pro2-Leu2-Pro3-CO) on the basis of extensive 2D NMR andMS spectra. | Hui DOU, Yan ZHOU, Shu lin PENG, Li Sheng DING Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041 | 2003 | Chinese Chemical Letters2003，14，9： | 7 |
| 15 | An Outbreak of Infections Caused by a Klebsiella pneumoniae ST11 Clone Coproducing Klebsiella pneumoniae Carbapenemase-2 and RmtB in a Chinese Teaching Hospital显示文摘 | Jun Li Ming-Xiang Zou Hai-Chen Wang Qing-Ya Dou Yong-Mei Hu Qun Yan Wen-En Liu | 2016 | Chinese Medical Journal2016，，17： | 6 |
| 16 | Long non-coding RNA HOTAIRM1 promotes proliferation and inhibits apoptosis of glioma cells by regulating the miR-873-5p/ZEB2 axis显示文摘Background:Glioblastoma is one of the most common malignant brain tumors.Conventional clinical treatment of glioblastoma is not sufficient,and the molecular mechanism underlying the initiation and development of this disease remains unclear.Our study aimed to explore the expression and function of miR-873a-5p in glioblastoma and related molecular mechanism.Methods:We analyzed the most dysregulated microRNAs from the Gene Expression Omnibus(GEO)database and examined the expression of miR-873-5p in 20 glioblastoma tissues compared with ten normal brain tissues collected in the Zhejiang Tongde Hospital.We then overexpressed or inhibited miR-873-5p expression in U87 glioblastoma cell lines and analyzed the phenotype using the cell counting kit-8 assay,wound healing assay,and apoptosis.In addition,we predicted upstream and downstream genes of miR-873-5p in glioblastoma using bioinformatics analysis and tested our hypothesis in U87 cells using the luciferase reporter gene assay and Western blotting assay.The differences between two groups were analyzed by Student’s t test.The Kruskal-Wallis test was used for the comparison of multiple groups.A P<0.05 was considered to be significant.Results:The miR-873-5p was downregulated in glioblastoma tissues compared with that in normal brain tissues(normal vs.tumor,0.762±0.231 vs.0.378±0.114,t=4.540,P<0.01).Overexpression of miR-873-5p inhibited cell growth(t=6.095,P<0.01)and migration(t=3.142,P<0.01)and promoted cell apoptosis(t=4.861,P<0.01),while inhibition of miR-873-5p had the opposite effect.Mechanistically,the long non-coding RNA HOTAIRM1 was found to act as a sponge of miR-873-5p to activate ZEB2 expression in U87 cells.Conclusions:We uncovered a novel HOTAIRM1/miR-873-5p/ZEB2 axis in glioblastoma cells,providing new insight into glioblastoma progression and a theoretical basis for the treatment of glioblastoma. | Yi-Hai Lin Liang Guo Feng Yan Zhang-Qi Dou Qian Yu Gao Chen | 2020 | Chinese Medical Journal2020，，2： | 5 |
| 17 | Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids显示文摘Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously, inactivation of a histone H3 deacetylase in Calcarisporium arbuscula had led to pleiotropic activation and overexpression of more than 75% of the biosynthetic genes and isolation of ten compounds. Further investigation of the crude extract of C. arbuscula Δhda A strain resulted in the isolation of twelve new diterpenoids including three cassanes(1-3), one cleistanthane(4), six pimaranes(5-10), and two isopimaranes(11 and 12) along with two know cleistanthane analogues. Their structures were elucidated by extensive NMR spectroscopic data analysis. Compounds 2 and 4 showed potent inhibitory effects on the expression of MMP1 and MMP2(matrix metalloproteinases family) in human breast cancer(MCF-7) cells. | Jian Bai Rong Mu Man Dou Daojiang Yan Bingyu Liu Qian Wei Jun Wan Yi Tang Youcai Hu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 5 |
| 18 | Activation of Na+/K+-ATPase attenuates high glucose-induced H9c2 cell apoptosis via suppressing ROS accumulation and MAPKs activities bv DRm217显示文摘多糖症在糖尿病是为心肌的 apoptosis 和机能障碍负责的主要因素之一。许多研究证明了在减少的 Na +/K+-ATPase 活动和糖尿病的心肌症之间有一种靠近的关系。然而,高导致葡萄糖的心肌的损害上的直接激活的 Na +/K+-ATPase 的效果仍然是未知的。这里,我们发现了那 DRm217, Na +/K+-ATPases 医生区域特定的 monoclonal 抗体和直接使活跃之物,能阻止高导致葡萄糖的 H9c2 细胞损害,反应的氧种(ROS ) 版本,和 mitochondrial 机能障碍。高葡萄糖处理减少了 Na +/K+-ATPase 活动和增加的细胞内部的 Ca 2+ 铺平,而 DRm217 增加了 Na +/K+-ATPase 活动和减轻的 Ca 2+ 超载。Ca 2+ 超载或关门的钠钙 exchanger (NCX 隧道) 的抑制能颠倒高导致葡萄糖的 ROS 增加和房间损害。另外, DRm217 能显著地稀释高导致葡萄糖的 p38, JNK 和 ERK1/2 phosphorylation,它涉及高导致葡萄糖的房间损害和 ROS 累积。我们的调查结果建议 DRm217 可以在心免于高葡萄糖的有害效果。由特定的 Na +/K+-ATPase 使活跃之物的高导致葡萄糖的心肌的房间损害的预防可以是一种吸引人的治疗学的选择。 | Xiaofei Yan Meng Xun Jing Li Litao Wu Xiaojuan Dou Jin Zheng | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 5 |
| 19 | Clinical characteristics of early and late drug-eluting stent in-stent restenosis and mid-term prognosis after repeated percutaneous coronary intervention显示文摘Background:The mechanism and characteristics of early and late drug-eluting stent in-stent restenosis(DES-ISR)have not been fully clarified.Whether there are different outcomes among those patients being irrespective of their repeated treatments remain a knowledge gap.Methods:A total of 250 patients who underwent initial stent implantation in our hospital,and then were readmitted to receive treatment for the reason of recurrent significant DES-ISR in 2016 were involved.The patients were categorized as early ISR(<12 months;E-ISR;n=32)and late ISR(≥12 months;L-ISR;n=218).Associations between patient characteristics and clinical performance,as well as clinical outcomes after a repeated percutaneous coronary intervention(PCI)were evaluated.Primary composite endpoint of major adverse cardiac events(MACEs)included cardiac death,non-fatal myocardial infarction(MI),or target lesion revascularization(TLR).Results:Most baseline characteristics are similar in both groups,except for the period of ISR,initial pre-procedure thrombolysis in myocardial infarction,and some serum biochemical indicators.The incidence of MACE(37.5%vs.5.5%;P<0.001)and TLR(37.5%vs.5.0%;P<0.001)is higher in the E-ISR group.After multivariate analysis,E-ISR(odds ratio[OR],13.267;[95%CI 4.984-35.311];P<0.001)and left ventricular systolic dysfunction(odds ratio[OR],6.317;[95%CI 1.145-34.843];P=0.034)are the independent predictors for MACE among DES-ISR patients in the mid-term follow-up of 12 months.Conclusions:Early ISR and left ventricular systolic dysfunction are associated with MACE during the mid-term follow-up period for DES-ISR patients.The results may benefit the risk stratification and secondary prevention for DES-ISR patients in clinical practice. | Jian-Feng Zheng Ting-Ting Guo Yuan Tian Yong Wang Xiao-Ying Hu Yue Chang Hong Qiu Ke-Fei Dou Yi-Da Tang Jin-Qing Yuan Yong-Jian Wu Hong-Bing Yan Shu-Bin Qiao Bo Xu Yue-Jin Yang Run-Lin Gao | 2020 | Chinese Medical Journal2020，，22： | 5 |
| 20 | Endothelial cells-targeted soluble human Delta-like 4 suppresses both physiological and pathological ocular angiogenesis显示文摘Due to its essential roles in angiogenesis, Notch pathway has emerged as an attractive target for the treatment of pathologic angiogenesis. Although both activation and blockage of Notch signal can impede angiogenesis, activation of Notch signal may be more promising because it was shown that long-term Notch signal blockage resulted in vessel neoplasm. However, an in vivo deliverable Notch ligand with highly efficient Notch-activating capacity has not been developed. Among all the Notch ligands, Delta-like4(Dll4) is specifically involved in angiogenesis. In this study, we generated a novel soluble Notch ligand h D4 R, which consists of the Delta-Serrate-Lag-2 fragment of human Dll4 and an arginine-glycine-aspartate(RGD) motif targeting endothelial cells(ECs). We demonstrated that h D4 R could bind to ECs through its RGD motif and effectively triggered Notch signaling in ECs. Further, we confirmed that h D4 R could suppress angiogenesis in vitro as manifested by network formation assay and sprouting assay. More importantly, h D4 R efficiently repressed neonatal retinal angiogenesis and laser-induced choroidal neovascularization(CNV) as well in vivo. In conclusion, we have developed an in vivo deliverable Notch ligand h D4 R, which suppresses angiogenesis both in vitro and in vivo, thus providing a new approach to tackle excessive angiogenesis relevant disease such as CNV. | YAN XianChun YANG ZiYan CHEN Yan LI Na WANG Li DOU GuoRui LIU Yuan DUAN JuanLi FENG Lei DENG SanMing HAN Hua ZHANG Ping | 2015 | Science China(Life Sciences)2015，58，5： | 5 |
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