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| 1 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
| 2 | State-periodic adaptive compensation of cogging and coulomb friction in per- manent magnet linear motors 显示文摘 | Ahn H S Chen Y Q Dou H F | 2005 | IEEE Transactions on Magnetics2005，41，1： | 1 |
| 3 | Synthesis and application of a novel mesoporous zeolite L in the catalyst for the HDS of FCC gasoline显示文摘 | HUO Q DOU T ZHAO Z | 2010 | App Catal A: Gen2010，381，12： | 1 |
| 4 | Fuzzy kappa for the agreement measure of fuzzy classifieations 显示文摘 | Dou W Ren Y Wu Q | 2007 | Neurocomputing2007，70，46： | 1 |
| 5 | Solvent cutting to make superior coal tar pitches 显示文摘 | Zhou J S Wei X Y Dou Y Q | 2011 | Adcanced Materials Research2011，239，： | 1 |
| 6 | Tuning of the structure and emission spectra of upconversion nanocrystals by alkali ion doping 显示文摘 | Dou Q Zhang Y | 2011 | Langmuir2011，27，13： | 1 |
| 7 | Relation ship between the methylation status of dietary fla vonoids and their growth inhibitory and apoptosis in ducing activities in human cancer cells 显示文摘 | Landis Piwowar K R Milacic V Dou Q P | 2008 | J Cell Bio chem2008，105，2： | 1 |
| 8 | Knoevenagel condensations of 1, 3-dicarbonyl compounds with aldehydes catalyzed by heterogeneous Ps-A1C13 without solvents 显示文摘 | ZHANG Y DOU Q DAI L | 2012 | RSC Advances2012，2，24： | 1 |
| 9 | Effieaey of phytic acid as an inhibitor of enzymatic and non-enzymatic browning in apple juice显示文摘 | DU Y J DOU S Q WU S J | 2012 | Food Chemistry2012，135，2： | 1 |
| 10 | Effect of metallic salts of glutaric acid on the formation of β-crystalline form in isotactic polypropylene显示文摘 | Dou Q Lu Q L Li H D | 2009 | Journal of Elastomers and Plastics2009，41，6： | 1 |
| 11 | Expression of integrin messenger ribonucleic acid in human endometrium:a quantitative reverse transcription polymerase chain reaction study显示文摘 | Dou Q Willians RS Chegini N | 1999 | Fertil Steril1999，71，2： | 1 |
| 12 | Expression of integrinmessager ribonucleic acid in human endometrium:a quantitativereverse transcription poly merase chain reaction study显示文摘 | Dou Q Williams S Chengini N | 1999 | Fertilsteril1999，71，2： | 1 |
| 13 | Effect of metallic salts of malonic acid on the formation of crystalline form in isotactic polypropylene显示文摘 | Dou Q Lu Q L Li H D | 2008 | Journal of Macromolecular Science Part B: Physics2008，47，5： | 1 |
| 14 | Regiospecificand enantioselective synthesis of methylated metabolites oftea catechins显示文摘 | Sheng BiaoWan Q Ping Dou Tak Hang Chan | 2006 | Tetrahedron2006，62，25： | 1 |
| 15 | Expression of integrin messenger ribonucleic acid in human endometrium:a quantitative reverse transcription polymerase chain reaction study显示文摘 | Dou Q Williams RS Chegini N | 1999 | Fertil Steril1999，71，2： | 1 |
| 16 | Blown bubble-spinning for fabrication of superfine fibers显示文摘 | DOU H ZUO B Q HE J H | 2012 | Thermal Science2012，16，5： | 1 |
| 17 | Preparation and application of zeolite beta with super-low SiO2/Al2O3 ratio显示文摘 | KANG S DOU T LI Q DUAN A ZHENG Y PAN H | 2008 | J Porous Materials2008，15，2： | 1 |
| 18 | Pollution characteristics of Pb, Zn, As, Cd in the Bijiang River显示文摘 | Yi Q Dou X D Huang Q R | 2012 | Procedia Environmental Sciences2012，13，： | 1 |
| 19 | The treatment of traditional Chinese medicine on Parkinson's disease显示文摘 | Li J Y Yang M H Dou Y Q | 2008 | Beijing J Tradit Chin Med2008，27，4： | 1 |
| 20 | Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis显示文摘 | MA L DOU H L WU Y Q | 2012 | BrJ Nutr2012，107，3： | 1 |
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