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| 1 | New strategies for colorectal cancer screening显示文摘Colorectal cancer (CRC) is still one of the leading causes of cancer-related death in Western countries, despite major improvements in its treatment. The dramatically high social and economic impact of CRC on human health makes the identification of a reliable screening tool of paramount importance. Current screening methods, such as the fecal occult blood test and colonoscopy do not adequately meet the ideal requisites of a screening test because, even if they are effective, they are limited first by too low specificity and sensitivity, or second by high invasiveness, costs and risk. Nowadays extended efforts are made by researchers to look for more reliable and effective screening tests based on a systems biology approach, using biological samples easily available, such as urine, breath, serum and feces. The effectiveness and reliability of several new attempts to screen these patients by non-invasive analysis of their biological samples using genomic (genetic and epigenetic alteration), transcriptomic (miRNA), proteomic (cancer-related antigens, new antibodies against tumor-associated antigens, mutated proteins) and metabolomic (volatile organic metabolites) methods are discussed in this review. Among the most interesting new screening tools, fecal fluorescent long-DNA, fecal miRNA and metabolomic evaluation in breath and/ or serum seem to be most promising. | Maria Di Lena Elisabetta Travaglio Donato F Altomare | 2013 | World Journal of Gastroenterology2013，19，12： | 12 |
| 2 | Cardiovascular risk after orthotopic liver transplantation, a review of the literature and preliminary results of a prospective study显示文摘Improved surgical techniques and greater efficacy of new anti-rejection drugs have significantly improved the survival of patients undergoing orthotopic liver transplantation(OLT). This has led to an increased incidence of metabolic disorders as well as cardiovascular and cerebrovascular diseases as causes of morbidity and mortality in OLT patients. In the last decade, several studies have examined which predisposing factors lead to increased cardiovascular risk(i.e., age, ethnicity, diabetes, NASH, atrial fibrillation, and some echocardiographic parameters) as well as which factors after OLT(i.e., weight gain, metabolic syndrome, immunosuppressive therapy, and renal failure) are linked to increased cardiovascular mortality. However, currently, there are no available data that evaluate the development of atherosclerotic damage after OLT. The awareness of high cardiovascular risk after OLT has not only lead to the definition of new but generally not accepted screening of high risk patients before transplantation, but also to the need for careful patient follow up and treatment to control metabolic and cardiovascular pathologies after transplant. Prospective studies are needed to better define the predisposing factors for recurrence and de novo occurrence of metabolic alterations responsible for cardiovascular damage after OLT. Moreover, such studies will help to identify the timing of disease progression and damage,which in turn may help to prevent morbidity and mortality for cardiovascular diseases. Our preliminary results show early occurrence of atherosclerotic damage, which is already present a few weeks following OLT, suggesting that specific, patient-tailored therapies should be started immediately post OLT. | Giuseppina Pisano Anna L Fracanzani Lucio Caccamo Maria F Donato Silvia Fargion | 2016 | World Journal of Gastroenterology2016，22，40： | 4 |
| 3 | Sphincteroplasty for fecal incontinence in the era of sacral nerve modulation显示文摘The role of sphincteroplasty in the treatment of patients with fecal incontinence due to anal sphincter defects has been questioned because the success rate declines in the long-term.A new emerging treatment for fecal incontinence,sacral nerve stimulation,has been shown to be effective in these patients.However,the success rate of sphincteroplasty may depend of several patient-related and surgical-related factors and the outcome from sphincteroplasty has been evaluated differently(with qualitative data) from that after sacral nerve stimulation(quantitative data using scoring systems and quality of life).Furthermore,the data available so far on the longterm success rate after sacral nerve modulation do not differ substantially from those after sphincteroplasty.The actual data do not support the replacement of sphincteroplasty with sacral nerve stimulation in patients with fecal incontinence secondary to sphincter defects. | Donato F Altomare Michele De Fazio Ramona Tiziana Giuliani Giorgio Catalano Filippa Cuccia | 2010 | World Journal of Gastroenterology2010，16，42： | 2 |
| 4 | Surgical management of acute carotid thrombosis after carotid stenting: a report of three eases显示文摘 | Setacci C de Donato G Setacci F | 2005 | J Vase Surg2005，42，5： | 1 |
| 5 | S100B's double life:intracellular regulator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochirn Biophys Acta2009，1793，6： | 1 |
| 6 | Combined peri- neal and endorectal repair of rectocele by circular stapler显示文摘 | Donato F Altomare MR Antonella V | 2002 | Dis Colon Rectum2002，，45： | 1 |
| 7 | A case-control study on family history of liver cancer as a risk factor for hepatocellular carcinoma in North Italy显示文摘 | Donato F Gelatti U Chiesa R | | 0，，： | 1 |
| 8 | Safety and feasibility of intravascular optical coherence tomography using a nonocclusive technique to evaluate carotid plaques before and after stent deployrnentj显示文摘 | Setacci C de Donato G Setacci F | 2012 | J Endovascular Ther2012，19，3： | 1 |
| 9 | Constipation, anthranoid laxatives, melanosis coli, and colon cancer: a risk assessment using aberrant crypt foci 显示文摘 | Nascimbeni R Donato F Ghirardi M | 2002 | Cancer Epidemiol Biomarkers Prey2002，11，： | 1 |
| 10 | Quality of life and sexual function after type c2/type Ⅲ radical hysterectomy for locally advanced cervical cancer: a prospective study 显示文摘 | Plotti F Sensone M Di Donato V | 2011 | J Sexual Medicine2011，8，3： | 1 |
| 11 | S100B~ s double life : in- tracellular regulator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochim Biophys Acta2009，1793，10： | 1 |
| 12 | A meta-analysis of epidemiological studies on the combined effect of hepatitis B and C virus infections in causing hepatocellular carcinoma 显示文摘 | Donato F Boffetta P Puoti M | 1998 | Int J Cancer1998，75，3： | 1 |
| 13 | Trigeminal laser-evoked potentials: A neurophysiological tool to detect post-surgical outcome in trigeminovascular contact neuralgia 显示文摘 | Squintani G Turri M Donato F | 2015 | Eur J Pain2015，19，2： | 1 |
| 14 | Predictive factors of renal involvement or relapsing disease in children with Henoch - Schonlein purpura 显示文摘 | Donato R Marcello C Gilda F | 2005 | Rheumatol Int2005，25，1： | 1 |
| 15 | CO21aser treatment for Bartholin gland abscess: ultrasound evaluation of risk recurrence 显示文摘 | Di Donato V Bellati F Casorelli A | 2013 | J Minim Invasive Gynecol2013，20，3： | 1 |
| 16 | S1006s double life:intracellular regulator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochim Biophys Acts2009，1793，6： | 1 |
| 17 | Vaginal cancer 显示文摘 | Di Donato V Bellati F Fischetti M | 2011 | Crit Rev Oncol Hematol2011，13，： | 1 |
| 18 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 19 | Effects of the time of day of walking on dietary behaviour, body composition and aerobic fitness in post -menopausal women 显示文摘 | Di Blasio A Di Donato F Mastrodicasa M | 2010 | Sports Med Phys Fitness2010，50，2： | 1 |
| 20 | Natural history of chronic hepatitis B: special emphasis on disease progression and prognostic factors 显示文摘 | Fattovich G Bortolotti F Donato F | 2008 | J Hepatol2008，48，2： | 1 |
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