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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | The impact of public R&D expenditure on business R&D 显示文摘 | Dominique G Bruno P | 2003 | Economics of Innovation and New Technology2003，，12： | 1 |
| 3 | Prognosis value of radionu clide angiography in patients with right ventricular arrhythmias 显示文摘 | Dominique LG Helene G Raphael P | 2001 | Circ2001，103，15： | 1 |
| 4 | Aboriginal method for studying in vitro the enzymatic degradation of cross-linked starch microspheres显示文摘 | Ghanla H Gilles P Dominique D | 1998 | Journal of Controlled Release1998，55，23： | 1 |
| 5 | Two-dimensionalprotein map of an “ale”-brewing yeast strain: proteomedynamics during fermentation显示文摘 | Dominique K Sandra Z Serge P | 2004 | FEMS Yeast Research2004，5，3： | 1 |
| 6 | Maximal bifix codes 显示文摘 | Veronique B Dominique P | 1999 | Theoretical Computer Science1999，218，： | 1 |
| 7 | Comual heterotopic pregnancy:a case report显示文摘 | Olivier P Guillaume D Dominique L | 2009 | J Med Case Reports2009，3，： | 1 |
| 8 | Arterial and portal circulation and parenchymal changes in Budd-Chiari syndrome:a study in 17 explanted livers显示文摘 | Vilgrain V Genin P | 2003 | Hepatology2003，37，3： | 1 |
| 9 | Steroid saponins from fenugreek seeds:extraction,purification,and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R P Yves D S Dominique M H | 1995 | Steroids1995，60，10： | 1 |
| 10 | A new polymorphism in the ApoE promoter associ-ated with risk of developing Alzheimer′s Disease显示文摘 | Jean-chaarles L Florence P Dominique C | 1998 | Human Molecular Genetics1998，7，3： | 1 |
| 11 | Short-term and long- term outcomes of interstitial lung disease in polymyositis and dermatomyositis: A series of 107 patients 显示文摘 | Marie I Hatron P Dominique S | 2011 | Arthritis & Rheumatism2011，63，11： | 1 |
| 12 | Short-term and long- term outcomes of interstitial lung disease in polymyositis and dermatomyositis: A series of 107 patients 显示文摘 | Marie I Hatron P Dominique S | 2011 | Arthritis & Rheumatism2011，63，11： | 1 |
| 13 | Residual stresses in surface induction hardening of steel: comparison between experiment and simulation 显示文摘 | Dominique C Thierry P L Philippe B | 2008 | Materials Science and Engineer2008，25，2： | 1 |
| 14 | The Long-Term Effects of Promotions on Category Incidence,Brand Choice,and Purchase Quantity显示文摘 | Koen P Dominique M Hanssens Siddarth S | 2002 | Journal of Marketing Research2002，，39： | 1 |
| 15 | Interindividual differences in anticancer drug eytotoxieity in primary human glioblastoma cells显示文摘 | Stphane P Beatrice LA Dominique L | 2007 | Experimental and Toxicological Pathology2007，58，4： | 1 |
| 16 | Changes in quantitative patterns of dead wood in Maritime pine plantations over time显示文摘 | Antoine B Céline M Dominique P | 2008 | Forest Ecology and Management2008，256，5： | 1 |
| 17 | Comparative effects of dietary methylmercury on gene expression in liver,skeletal muscle,and brain of the zebrafish(Danio rerio)显示文摘 | Gonzalez P Dominique Y Massabuau JC Boudou A Bourdineaud JP | 2005 | Environ Sci Technol2005，39，11： | 1 |
| 18 | The Interaction between ATP-Actin and ADP-Actin显示文摘 | DOMINIQUE P MARIE FC EDWARDDK | 1985 | The Journal of Biological Chemistry1985，280，： | 1 |
| 19 | 查看详情显示文摘 | Andrew R P Victoria L W Dominique D | | 0，，： | 1 |
| 20 | Who benefits from price promotions? 显示文摘 | Shuba S S Keon P Dominique M H Marnik G D | 2002 | Harvard Business Review2002，80，9： | 1 |
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