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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Impact of overgrazing on the transmission of Echinococcus multilocularis in Tibetan pastoral communities of Sichuan Province,China显示文摘背景过度放牧被假定增加是包虫 multilocularis 的中间的主人的小哺乳动物的人口密度,在 Qinghai 西藏高原的牙槽的包虫病的病原体。这研究测试了过度放牧可能支持的假设通过增加小哺乳动物的人口的包虫 multilocularis 传播,在擦伤惯例的西藏的牧剧 communities.Methods 的中间的主人,小哺乳动物索引和狗包虫 rnultilocularis 感染数据被收集分析在用的 nonpararnetric 测试和多重逐步的逻辑 regression.Results 过度放牧和包虫 rnultilocularis 传播之间的关系调查一公社的牧场存在,可得到的牧草为放牧是缺乏的。开(普通) 牧场被过度放牧并且与附近的 fenced 相比有小哺乳动物的更高的洞穴密度(私人) 牧场;由附近的 fenced 区域测量的开的牧场上的这个高过度放牧压力在开的牧场导致了小哺乳动物的更高的洞穴密度。在开的牧场的小哺乳动物的中部的洞穴密度独立地与附近犬的包虫 multilocularis 感染被联系(P=0.003, OR=1.048 ) 过度放牧的 .Conclusion 可以通过增加小哺乳动物的人口密度支持包虫 multilocularis 的传播。 | WANG Qian XIAO Yong-fu Dominique A Vuitton Peter M Schantz Francis Raoul Christine Budke Maiza Campos-Ponce Philip S Craig Patrick Giraudoux | 2007 | Chinese Medical Journal2007，，3： | 20 |
| 3 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 4 | Comparative Evaluation of 29 Commercial H elicobacter pylori Serological Kits显示文摘 | Christophe Burucoa Jean‐Charles Delchier Anne Courillon‐Mallet Jean‐Dominique Korwin Francis Mégraud Frank Zerbib Josette Raymond Jean‐Louis Fauchère | 2013 | Helicobacter2013，，3： | 3 |
| 5 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 6 | More epidural than intravenous sufentanil is required to provide comparable postoperative pain relief显示文摘 | CHRISTOTOPHE M BRUNO G DOMINIQUE F | 2001 | Anesth analg2001，93，2： | 1 |
| 7 | Develop ment and validation of the Patient Assessment of Con stipation Quality of Life questionnaire显示文摘 | Patrick M Christine D Dominique D | 2005 | Scandinavian J Gastroenterol2005，40，5： | 1 |
| 8 | presynaptic remodeling contributes to activity dependent synaptogenesis显示文摘 | Irina N Pascal J Dominique M | 2003 | Neuroscience2003，23，24： | 1 |
| 9 | ^29SiMAS NMR study of dicalcium silicate:the structural influence of sulfate and alumina stabilizers显示文摘 | LAURENTB CATHERINE B DOMINIQUE M | 1995 | J Am Ceram Soc1995，78，10： | 1 |
| 10 | Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire显示文摘 | Patrick M Christine D Dominique D | 2005 | Scandinavian J Gastro- enterol2005，40，5： | 1 |
| 11 | Spalling and pore pressure in HPC at high temperatures显示文摘 | Pierre K Francois Dominique M Daniel Q | 2000 | Cement and Concrete Research2000，30，： | 1 |
| 12 | Coordina- tion chemistry of calix-phosphanes: cooperativity in the assembly of a tetragold calixarene complex显示文摘 | Cedric B D Dominique M Anthony H | 2000 | Eur J Inorg Chem2000，，： | 1 |
| 13 | Effects of freezing and thawing on mammalian oocyte 显示文摘 | Jondet M Dominique S Scholler R | 1984 | Cryobiology1984，21，2： | 1 |
| 14 | Empirical estimation of tail correlation using copulas:application to Asian markets显示文摘 | Cyril C Dominique M G | 2005 | Quantitative Finance2005，5，5： | 1 |
| 15 | Detection of irradiated deepl-Mfrozen foodstuffs by comparison of DEFT and APC counts显示文摘 | Mariel-MPierre Copln Dominique Jehanno and Bourgeois C M | 1993 | Journal of AppLied Bacteriology1993，75，： | 1 |
| 16 | Presynaptic remodeling contributes to activity-dependen, synaptogenesis显示文摘 | Irina N Pascal J Dominique M | 2003 | Neuroscience2003，23，24： | 1 |
| 17 | Biochemical characterization of Isocitrate dehydrogenase from Methylococcus capsulatus reveals a unique NAD^+-dependent momotetrameric enzyme 显示文摘 | Runar S Dominique M Anita E F | 2007 | Archives of Microbiology2007，187，5： | 1 |
| 18 | Inter- conversion between active and inactive TATA-binding protein transcription complexes in the mouse genome 显示文摘 | Mohamed-Amin C Dominique K Igor M | 2012 | Nucleic Acids Research2012，40，4： | 1 |
| 19 | Simple design rules for optimal design of dielectric temperature-compensated sapphire resonators 显示文摘 | Tobar M E Dominique Cros John G Hartnett | 2003 | IEEE trans on Ultrasonics Ferroelectricy Control2003，50，9： | 1 |
| 20 | Stem cells of the alveolar epithelium 显示文摘 | Mark J D Griffiths Dominique Bonnet Sam M Janes | 2005 | Lancet2005，366，9481： | 1 |
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