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| 1 | Engineering complex systems applied to risk management in the mining industry显示文摘Related to complexity, there is a wide diversity of concepts, ranging from ‘‘systemic' to ‘‘complex', implying a need for a unified terminology. Per different authors, the main drivers of complexity can be found in human behaviour and uncertainty. This complexity, structural or dynamic can be organizational, technological, or nested in their relationship. ISO international standard 31000:2009 definition of risk management ‘‘coordinated activities to direct and control an organization with regard to risk', when applied to economic sectors, industry, services, project, or activity, it requires the use of models or theories as guidelines. Therefore, as its basic elements comprehend human behaviour and/or uncertainty, risk management to be effective and adapted as much as possible to reality, must be operational within complex systems, as already demonstrated in different R&D environments. Risk management faces demanding challenges when approaching specific and endogenous needs, such as the mining sector. This paper presents a multivariable function analysis methodology approach based on complex system modelling and through real data corresponding to a risk management tool in the mining sector. | Domingues Maria S.Q. Baptista Adelina L.F. Diogo Miguel Tato | 2017 | International Journal of Mining Science and Technology2017，27，4： | 7 |
| 2 | Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor显示文摘Approximately 10% of patients with gastrointestinal stromal tumors (GIST) develop other neoplasms, either synchronously or metachronously. In this report we describe coexistence of a gastrointestinal stromal tumor and a hepatic perivascular epithelioid cell tumor (PEComa) in a 51-year-old woman with no evidence of tuberous sclerosis. A subcapsular hepatic nodule (0.8 cm in diameter) was found during surgery for symptomatic gastric neoplasm (15 cm in diameter) arising from the lesser curvature. Both tumors revealed histomorphological and immunohistochemical features confirming a diagnosis of a small incidental hepatic PEComa and a high risky extramural gastric GIST, respectively. The patient remained disease-free 25 mo after surgery with no evidence of tumor recurrence or new neoplasms. To our knowledge, this is the first report of PEComa in a patient with GIST. Hepatic lesions detected synchronously or metachronously in patients with GISTs may represent histogenetically distinct lesions and should be sampled to confirm or exclude metastatic GISTs. | Carlos Eduardo Paiva Francisco Alves Moraes Neto Abbas Agaimy Maria Aparecida Custódio Domingues Silvia Regina Rogatto | 2008 | World Journal of Gastroenterology2008，14，5： | 6 |
| 3 | Brazilian biosafety law and the new breeding technologies显示文摘Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two decades.Although this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to country.In recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food security.In Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and management.However,most of new breeding technologies did not exist at that time and were not considered in this law.In2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation system.Briefly,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk assessment.If the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing procedures.Currently,152 GM products are commercially approved in Brazil.In 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six products.It is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops. | Alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno FERNANDES | 2020 | Frontiers of Agricultural Science and Engineering2020，7，2： | 5 |
| 4 | Intestinal anti-inflammatory activity of Ground Cherry(Physalis angulata L.)standardized CO2 phytopharmaceutical preparation显示文摘AIM To investigate the effects of Ground Cherry(Physalis angulata L.)standardized supercritical CO_2 extract in trinitrobenzenesulphonic acid(TNBS)model of rat intestinal inflammation.METHODS The animals were divided into groups that received vehicle or P.angulata extract(PACO_2)orally at the doses 25,50 and 100 mg/kg daily by 5 d before TNBS damage.Protective effects of PACO_2 were assessed by macroscopic analysis,biochemical determinations of the levels of myeloperoxidase(MPO),alkaline phosphatase(ALP),glutathione and cytokines(such as INF-γ,IL-1β,IL-6,IL-10 and TNF-α),gene expression evaluation(including Hsp70,heparanase,NF-κB,mitogenactivated protein kinases(Mapk)1,3,6 and 9,and the mucins genes Muc 1,2,3 and 4)and histopathological studies using optical,and electronic(transmission and scanning)microscopy.RESULTS PACO2 extract promoted a significant reduction in MPO and ALP activities,reducing oxidative stress and neutrophil infiltration.These effects were accompanied by significant reduction of colonic levels of IFN-γand IL-6 and down-regulation of heparanase,Hsp70,Mapk3,Mapk9,Muc1 and Muc2 genes expression when compared with TNBS-control animals.In addition,protective effects were also evidenced by reduced neutrophil infiltration,recovery of cell architecture and replacement of mucin by histopathological and ultrastructural analysis.CONCLUSION Physalis angulata supercritical CO2 extract is an intestinal anti-inflammatory product that modulates oxidative stress,immune response and expression of inflammatory mediators,with potentially utility for treating inflammatory bowel disease. | luiz domingues almeida junior ana elisa valencise quaglio celso acácio rodrigues de almeida costa Luiz Claudio Di Stasi | 2017 | World Journal of Gastroenterology2017，23，24： | 4 |
| 5 | Diagnosis of HSE by MRI and PCR assay of CSF显示文摘 | Domingues RB Fink MC Tsanaclis AM | 1998 | J Neurol Sci1998，157，2： | 2 |
| 6 | Stress and failure analyses of scarf repaired CFRP laminates using a cohesive damage model显示文摘 | R. D. S. G. Campilho M. F. S. F. Moura J. J. M. S. Domingues | 2007 | Journal of Adhesion Science and Technology2007，，9： | 2 |
| 7 | Extraction Topographic Structure from Digital Elevation Data for Geographic Information System Analysis显示文摘 | Jenson K Domingue JO | 1998 | Photogrammetry Engineering and Remote Sensing1998，54，11： | 2 |
| 8 | From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?显示文摘Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.Clinically,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons.Current treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal damage.Therefore,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease.For instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell death.Despite the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative process.Therefore,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based strategies.Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic neurons.Such approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease.Thus,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease. | Rita Caridade Silva Helena Sofia Domingues António J.Salgado Fábio G.Teixeira | 2022 | Neural Regeneration Research2022，17，5： | 2 |
| 9 | 显示文摘 | Domingues RB Lakeman FD Mayo MS | 1998 | J Clin Microbiol1998，36，8： | 1 |
| 10 | Microstructural and mechanical study of zirconia hydroxyapatite composite ceramics for biomedical applications 显示文摘 | Silva V V Lameiras F S Domingues R Z | 2001 | Compos Sci Technol2001，61，2： | 1 |
| 11 | The RNA reeognition mo- tif, a plastic RNA-binding platform to regulate post-transcription- al gene expression显示文摘 | Maris C Domingue Z C Allain F H | 2005 | FEBS J2005，272，9： | 1 |
| 12 | Survivin and ni- tric oxide inducible synthase production during 4NQO-induced rat tongue carcinogenesis, a possible relationship 显示文摘 | Ribeiro DA Kitakawa D Domingues MA | 2007 | Exp Mol Pathol2007，83，1： | 1 |
| 13 | Integrons : ve- hicles and pathways for horizontal dissemination in bacteria显示文摘 | Domingues S da Silva GJ Nielsen KM | 2012 | Mob Genet Elements2012，2，5： | 1 |
| 14 | Anti- Helicobacter pylori and urease inhibitory activities of resveratrol and red wine显示文摘 | Luísa Paulo Mónica Oleastro Eugenia Gallardo Jo?o António Queiroz Fernanda Domingues | 2011 | Food Research International2011，，4： | 1 |
| 15 | Ontology-driven document enrichment:Principles,tools and applications显示文摘 | Enrico Motta Simon Buchingham Shum John Domingue | 2000 | Int J Human-Computer Studies2000，52，： | 1 |
| 16 | Phylogenetic relationships of Brazilian bovine respiratory syncytial virus isolates and molecular homology modeling of attachment glycoprotein显示文摘 | Spilki FR Almeida RS Domingues HG | 2006 | Virus Res2006，116，12： | 1 |
| 17 | Gdnital mycoplasma in women attending a family planning clinician, Guinea-Bissau and their susceptibility to antimicrobial agents显示文摘 | Domingues D Tavora Tavira L Duarte A | 2003 | Acta Trop2003，86，1： | 1 |
| 18 | ScholOnto: an ontology-based digital library server for research documents and discourse显示文摘 | Shum S B Motta E Domingue J | 2000 | International Journal on Digital Libraries2000，3，： | 1 |
| 19 | The influence of cul-ture conditions on mycelial structure and eellulase production by Trichoderma reese/Rut C-30显示文摘 | Domingues F C Queiroz J A Cabral J M S | 2000 | Enzyme and Microbial Technolo-gy2000，26，5： | 1 |
| 20 | Metformin but not glyburide prevents high glucose-Induced abnormalities in Relaxation and intracellular Ca2+ transients in adult rat ventricular myocytes显示文摘 | Ren J Ligia J Domingue Z | 1999 | Diabetes1999，48，： | 1 |
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