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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | 全科住院医生以患者为中心使用电子病历的干预前后比较研究显示文摘目的目前,临床接诊时常用到电子病历(EHR)。由于使用EHR能给医患关系带来不利影响,因此就'以患者为中心'使用HER已发表了相关推荐方案。然而,当前培训对提高临床接诊EHR应用率的效果尚不明确。本研究旨在调查培训对全科住院医生使用EHR时与患者沟通技巧的影响,并探究其沟通技巧是否因接诊内容而变化。方法本研究在瑞士日内瓦大学医院全科医学科进行,研究对象为全科住院医生。干预措施为为期3个月的培训,包括基于观看接诊录像进行的2个大型的小组培训以及2~4个个性化辅导培训。使用自填式问卷调查全科住院医生对使用EHR的态度。使用Roter沟通互动分析系统以及EHR具体项目评估干预前后全科住院医生执业的情况。干预效果以全科住院医生对使用EHR的态度和在接诊过程前10 min内客观需要使用EHR的情况进行评价。结果招募的27名全科住院医生有17名参与了本研究。研究对象在约30%的接诊里应用了EHR。干预后,认为使用EHR使医患关系变差的全科住院医生数量减少,而且其能够更加放松地使用EHR。全科住院医生使用光标定位EHR的比例在干预后有所增加[干预前:0.77(SD=1.69);干预后:1.80(SD=3.35),P=0.035]。当接诊社会心理疾病的患者时,全科住院医生使用EHR的比例下降(干预前:24.5%,干预后:9.76%,P<0.001)。结论本研究表明,培训可提高全科住院医生接诊时使用EHR的沟通技巧,与敏感的社会心理疾病患者的沟通改善尤其显著。今后,相关的研究可侧重于以患者视角探讨全科医生沟通技巧与其关联性,以及这些沟通技巧的有效性。 | LANIER C DOMINIC DAO M HUDELSON P 本刊编辑部 | 2017 | 中国全科医学2017，20，26： | 2 |
| 3 | Measurement of the specific surface area of 176 snow samples using methane adsorption at 77 K显示文摘 | Lot'c Legagneux Axel Cabanes Florent Domine | 2002 | Journal of Geophysical Research2002，107，17： | 1 |
| 4 | Packaging Scorecarda Pack aging Performance Evaluation Method 显示文摘 | OLSMATS C DOMINIC C | 2007 | Packaging Technology and Science2007，5，10： | 1 |
| 5 | Hydrogen production by sequential cracking of biomass-derived pyrolysis oil over noble metal catalysts supported on ceria-zirconia显示文摘 | IOJOIU E E DOMINE M E DAVIDIAN T GUILHAUME N MIRODATOS C | 2007 | App Catal A2007，323，： | 1 |
| 6 | Kinetics of hexane pyrolysis at very high pressures显示文摘 | DOMINE F MARQUIRE P M MULLER C | 1990 | Energy & Fuels1990，4，1： | 1 |
| 7 | Optical properties ofa retroreflecting sheet显示文摘 | Dominic C O Grahame E F David J E | 1999 | Applied Optics1999，38，19： | 1 |
| 8 | Increased preoperativeplatelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas显示文摘 | BrownKM Domin C Aranha GV | 2005 | Am J Surg2005，189，： | 1 |
| 9 | Packaging Seorecard-a Packaging Performance Evaluation Method显示文摘 | OLSMATS C DOMINIC C | 2003 | Packaging Technology and Science2003，16，1： | 1 |
| 10 | Vertical Handover DecisionMaking Algorithm Using Fuzzy Logic for the Integrated Radio-and-OW System显示文摘 | HOU J D DOMINIC C O | 2006 | IEEE Trans Wireless Comm2006，5，： | 1 |
| 11 | Integrating Packaging Suppliers into the Supply/ Demand Chain显示文摘 | DOMINIC C | 2005 | Packaging Technology and Science2005，18，2： | 1 |
| 12 | A qualitative analysis on the effect of external vibrations on the performance of relays显示文摘 | DOMINIC J C | 1996 | IEEE Africon1996，4，2： | 1 |
| 13 | What Does the Public Want from Agriculture and the Countryside? A Review of Evidence and Methods 显示文摘 | Hall C Alistair M & Dominic M | 2004 | Journal of Rural Studies2004，20，2： | 1 |
| 14 | Serum adiponectin is associated with adverse outcomes of asthma in men but not in women显示文摘 | Sood A Dominic E Quails C | 2011 | Front Pharmacol2011，2，： | 1 |
| 15 | Molecular clo- ning and biochemical characterization of a Drosophila PtdIns- specific phosphoinositide 3-kinase显示文摘 | Linassier C MacDougall LK Domin J | 1997 | Biochemical Journal1997，321，： | 1 |
| 16 | Prevalence of depression in consecutive patients with type 2 diabetes mellitus of 5-year duration and its impact on glycemic control显示文摘 | MATHEW C S DOMINIC M ISAAC R | 2012 | Indian Journal of Endocrinology & Metabolism2012，16，5： | 1 |
| 17 | Vertical Handover Decision-Making Algorithm Using Fuzzy Logic for the Integrated Radio-and-OW System 显示文摘 | HOU J D DOMINIC C O | 2006 | IEEE Trans on Wireless Communications2006，5，1： | 1 |
| 18 | Indoor optical wireless MIMO system with an imaging receiver显示文摘 | Katrina D Dambul Dominic C O′Brien Grahame Faulkner | 2011 | IEEE Photonics Technology Letters2011，23，2： | 1 |
| 19 | Emergence of fluoroquinolone resistance among multiply resistant strsins of Streptococcus peumoniae in Hong Kong 显示文摘 | Ho P L Que T L Dominic N C | 1999 | Antimicrobial Agents Chemother1999，43，5： | 1 |
| 20 | Native or raw starch digestion: a key step in energy efficient biorefining of grain显示文摘 | George H Robertson Dominic W S Wong Charles C Lee | 2006 | Journal of Agri- cultural and Food Chemistry2006，54，2： | 1 |
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