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| 1 | Stochastic collocation for device-level variability analysis in integrated photonics显示文摘We demonstrate the use of stochastic collocation to assess the performance of photonic devices under the effect of uncertainty. This approach combines high accuracy and efficiency in analyzing device variability with the ease of implementation of sampling-based methods. Its flexibility makes it suitable to be applied to a large range of photonic devices. We compare the stochastic collocation method with a Monte Carlo technique on a numerical analysis of the variability in silicon directional couplers. | Yufei Xing Domenico Spina Ang Li Tom Dhaene Wim Bogaerts | 2016 | Photonics Research2016，4，2： | 3 |
| 2 | Numerical modeling of a linear photonic system for accurate and efficient time-domain simulations显示文摘In this paper, a novel modeling and simulation method for general linear, time-invariant, passive photonic devices and circuits is proposed. This technique, starting from the scattering parameters of the photonic system under study, builds a baseband equivalent state-space model that splits the optical carrier frequency and operates at baseband, thereby significantly reducing the modeling and simulation complexity without losing accuracy.Indeed, it is possible to analytically reconstruct the port signals of the photonic system under study starting from the time-domain simulation of the corresponding baseband equivalent model. However, such equivalent models are complex-valued systems and, in this scenario, the conventional passivity constraints are not applicable anymore. Hence, the passivity constraints for scattering parameters and state-space models of baseband equivalent systems are presented, which are essential for time-domain simulations. Three suitable examples demonstrate the feasibility, accuracy, and efficiency of the proposed method. | YINGHAO YE DOMENICO SPINA YUFEI XING WIM BOGAERTS TOM DHAENE | 2018 | Photonics Research2018，6，6： | 2 |
| 3 | Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children显示文摘AIM:To compare intradermal(ID) and intramuscular(IM) booster doses,which have been used in healthy and high risk subjects,such as healthcare workers,haemodialysis patients,human immunodeficiency virus patients,and renal transplant recipients unresponsive to initial hepatitis B vaccination,in celiac individuals.METHODS:We conducted our study on 58 celiac patients,vaccinated in the first year of life,whose blood analysis had showed the absence of protective hepatitis B virus(HBV) antibodies.All patients had received the last vaccine injection at least one year before study enrolment and they had been on a gluten free diet for at least 1 year.In all patients we randomly performed an HBV vaccine booster dose by ID or IM route.Thirty celiac patients were revaccinated with recombinant hepatitis B vaccine(Engerix B) 2 g by the ID route,while 28 celiac patients were revaccinated with Engerix B 10 g by the IM route.Four weeks after every booster dose,the anti-hepatitis B surface(HBs) antibody titer was measured by an enzyme-linked immuneadsorbent assay.We performed a maximum of three booster doses in patients with no anti-HBs antibodies after the first or the second vaccine dose.The cut off value for a negative anti-HBs antibody titer was 10 IU/L.Patients with values between 10 and 100 IU/L were considered 'low responders' while patients with an antibody titer higher than 1000 IU/L were considered 'high responders'.RESULTS:No significant difference in age,gender,duration of illness,and years of gluten intake was found between the two groups.We found a high percentage of 'responders' after the first booster dose(ID = 76.7%,IM = 78.6%) and a greater increase after the third dose(ID = 90%,IM = 96.4%) of vaccine in both groups.Moreover we found a significantly higher number of high responders(with an anti-HBs antibody titer > 1000 IU/L) in the ID(40%) than in the IM(7.1%) group,and this difference was evident after the first booster dose of vaccination(P < 0.01).No side effects were recorded in performing delivery of the vaccine by either the ID or IM route.CONCLUSION:Our study suggests that both ID and IM routes are effective and safe options to administer a booster dose of HBV vaccine in celiac patients.However the ID route seems to achieve a greater number of high responders and to have a better cost/benefit ratio. | Salvatore Leonardi Andrea Domenico Praticò Elena Lionetti Massimo Spina Giovanna Vitaliti Mario La Rosa | 2012 | World Journal of Gastroenterology2012，18，40： | 2 |
| 4 | Migraine, Celiac Disease, and Cerebral Calcifications: A New Case显示文摘 | Domenico D’Amico Andrea Rigamonti Luisa Spina Stefania Bianchi‐Marzoli Maurizio Vecchi Gennaro Bussone | 2005 | Headache: The Journal of Head and Face Pain2005，，9： | 1 |
| 5 | Platelets are essential for leukocyte recruitment in allergic inflammation显示文摘 | Simon C. Pitchford Hiroshi Yano Rebecca Lever Yanira Riffo-Vasquez Silvia Ciferri Mark J. Rose Silvia Giannini Stefania Momi Domenico Spina Brian O'Connor Paolo Gresele Clive P. Page | 2003 | The Journal of Allergy and Clinical Immunology2003，，1： | 1 |
| 6 | Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients显示文摘 | Stefania Mondello Domenico Italiano Maria Stella Giacobbe Patrizia Mondello Giuseppe Trimarchi Carmela Aloisi Placido Bramanti Edoardo Spina | 2010 | Nutrition2010，，6： | 1 |
| 7 | Time-domain compact macromodeling of linear photonic circuits via complex vector fitting显示文摘In this paper, a novel baseband macromodeling framework for linear passive photonic circuits is proposed, which is able to build accurate and compact models while taking into account the nonidealities,such as higher order dispersion and wavelength-dependent losses of the circuits. Compared to a previous modeling method based on the vector fitting algorithm, the proposed modeling approach introduces a novel complex vector fitting technique. It can generate a half-size state-space model for the same applications, thereby achieving a major improvement in efficiency of the time-domain simulations. The proposed modeling framework requires only measured or simulated scattering parameters as input,which are widely used to represent linear and passive systems. Three photonic circuits are studied to demonstrate the accuracy and efficiency of the proposed technique. | Yinghao Ye Domenico Spina Dirk Deschrijver Wim Bogaerts Tom Dhaene | 2019 | Photonics Research2019，7，7： | 0 |
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