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| 1 | Endocrine radionuclide scintigraphy with fusion single photon emission computed tomography/computed tomography显示文摘AIM: To review the benefits of single photon emission computed tomography(SPECT)/computed tomography(CT) hybrid imaging for diagnosis of various endocrine disorders.METHODS: We performed MEDLINE and Pub Med searches using the terms: 'SPECT/CT'; 'functional anatomic mapping'; 'transmission emission tomography'; 'parathyroid adenoma'; 'thyroid cancer'; 'neuroendocrine tumor'; 'adrenal'; 'pheochromocytoma'; 'paraganglioma'; in order to identify relevant articles published in English during the years 2003 to 2015. Reference lists from the articles were reviewed to identify additional pertinent articles. Retrieved manuscripts(case reports, reviews, meta-analyses and abstracts) concerning the application of SPECT/CT to endocrine imaging were analyzed to provide a descriptive synthesis of the utility of this technology.RESULTS: The emergence of hybrid SPECT/CT camera technology now allows simultaneous acquisition of combined multi-modality imaging, with seamless fusion of three-dimensional volume datasets. The usefulness of combining functional information to depict the biodistribution of radiotracers that map cellular processes of the endocrine system and tumors of endocrine origin, with anatomy derived from CT, has improved the diagnostic capability of scintigraphy for a range of disorders of endocrine gland function. The literature describes benefits of SPECT/CT for ^(99m)Tc-sestamibi parathyroid scintigraphy and ^(99m)Tc-pertechnetate thyroid scintigraphy, ^(123)I- or ^(131)I-radioiodine for staging of differentiated thyroid carcinoma, ^(111)In- and ^(99m)Tclabeled somatostatin receptor analogues for detection of neuroendocrine tumors, ^(131)I-norcholesterol(NP-59) scans for assessment of adrenal cortical hyperfunction, and ^(123)I- or ^(131)I-metaiodobenzylguanidine imaging for evaluation of pheochromocytoma and paraganglioma.CONCLUSION: SPECT/CT exploits the synergism between the functional information from radiopharmaceutical imaging and anatomy from CT, translating to improved diagnostic accuracy and meaningful impact on patient care. | Ka-Kit Wong Arpit Gandhi Benjamin L Viglianti Lorraine M Fig Domenico Rubello Milton D Gross | 2016 | World Journal of Radiology2016，8，6： | 3 |
| 2 | Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model显示文摘AIM:To investigate the role of epidermal growth factor receptor(EGFR) in colitis-associated dysplasia using the EGFR tyrosine kinase inhibitor erlotinib.METHODS:Sprague-Dawley rats received trinitrobenzene sulfonic acid(TNBS;30 mg in 50% ethanol,ic),followed 6 wk later by reactivation with TNBS(5 mg/kg,iv) for 3 d.To induce colitis-associated dysplasia,rats then received TNBS(iv) twice a week for 10 wk.One group received erlotinib(10 mg/kg,ip) for 1 wk before the start of the reactivation of the colitis and 2 wk after(21 d);the rest received the vehicle.After rats were euthanized,the colons were removed and analyzed for damage and expression of the EGFR downstream effectors Erk1/2 and c-Myc.RESULTS:Ninety percent of the vehicle-treated animals had dysplasia in any region of the colon.Erlotinib-treated animals had a significant decrease in the incidence of dysplasia compared to vehicle-treated animals in all regions of the colon(50.00% ± 11.47% vs 90.00% ± 10.00% in proximal,P < 0.05;15.00% ± 8.19% vs 50.00% ± 16.67% in mid,P < 0.05;and 20.00% ± 9.17% vs 70.00% ± 15.28% in distal,P < 0.01).Erlotinib-treated animals also had reduced cell proliferation,reduced active Erk1/2,and reduced c-Myc in colon epithelium compared with the vehicle-treated animals.In vitro,erlotinib treatment was shown to markedly decrease c-Myc and pErk1/2 levels in rat epithelial cells.Proliferation of rat epithelial cells was stimulated by epidermal growth factor and inhibited by erlotinib(P < 0.05).CONCLUSION:Erlotinib can decrease the development of colitis-associated dysplasia,suggesting a potential therapeutic use for erlotinib in patients with long-standing colitis. | Beatriz Pagán Angel A Isidro Myrella L Cruz Domenico Coppola Caroline B Appleyard | 2011 | World Journal of Gastroenterology2011，17，44： | 1 |
| 3 | Association betweenidiopathic retroperitoneal fibrosis and autoimmune thyroiditis :a case-control study 显示文摘 | Graziano C Maria L Domenico C | 2015 | Autoimmunity Reviews2015，14，1： | 1 |
| 4 | The complete DNA sequence of the mitochondrial genome of Podospora anserina 显示文摘 | CUMMINGS D J MCNALLY K L DOMENICO J M | 1990 | Cun~nt genetics1990，17，5： | 1 |
| 5 | IL- 10 and TNF- ? Polymorphisms and Recovery from HCV Infection显示文摘 | Domenico L Calogero C Rosa DS | 2003 | Human Immunology2003，64，7： | 1 |
| 6 | Three-Dimensional Electroanatomical Voltage Mapping and Histologic Evaluation of Myocardial Substrate in Right Ventricular Outflow Tract Tachycardia 显示文摘 | Domenico C Cristina B Loira L | 2008 | J Am Coll Cardiol2008，51，： | 1 |
| 7 | Conservation treatment by chemotherapy and uterine arteries embolization of a cesarean scar pregnancy显示文摘 | Fabio G Domenico L Massimo F | 2002 | Eur J Obstet Gynecol Reprod Biol2002，103，2： | 1 |
| 8 | A hybrid procedure strategy for vehicle localization system:design and prototyping显示文摘 | Fiengo G Domenico D D Glielmo L | 2009 | Control Engineering Practice2009，17，1： | 1 |
| 9 | Conservation treatment by chemotherapy and uterine arteries embolization of a cesarean scar preg- nancy显示文摘 | Fabio G Domenico L Massimo F | 2002 | Eur J Obstet Gynecol Reprod Biol2002，103，： | 1 |
| 10 | Reliability assessment of a gas chromatographic method for polycyclic aromatic hydrocarbons in olive oil显示文摘 | Menichini E Di Domenico A Bonanni L | 1991 | Journal of Chromatography A1991，555，12： | 1 |
| 11 | Three-dimensional electro- anatomical voltage mapping and histologie evaluation of myocardial substrate in fight ventricular outflow tract tachyeardia显示文摘 | Domenico C Cristina B Loira L | 2008 | J Am Coll Cardiol2008，51，7： | 1 |
| 12 | Grids and Grid Technologies for Wide-Area Distributed Computing 显示文摘 | MARK B RAJKUMAR B DOMENICO L | 2002 | International Journal of Software: Practice and Experience (SPE)2002，32，15： | 1 |
| 13 | Treatment of paper and pulp wastewater and removal of odorous compounds by a Fenton-like process at the pi- lot scale 显示文摘 | Tambosi L Jose Domenico Di Michele Schirmer N Waldir | 2006 | Journal of Chemical Technology and Bio- technology2006，81，7： | 1 |
| 14 | Inexpensive anatomical trainer for bronchoscopy显示文摘 | Di Domenico S Simonassi C Chessa L | 2007 | Interact Cardiovase Thorae Surg2007，6，： | 1 |
| 15 | Tarsometatarsal/Lisfranc joint显示文摘 | Domenico L A Cross D | 2012 | Clin Podiatr Med Surg2012，29，2： | 1 |
| 16 | Numerical investigations on the working cycle of a ilydraulic breaker: Off- design performance and influence of design parameters 显示文摘 | Antonio F Antonio G Domenico L F | 2006 | International Journal of Fluid Power2006，7，3： | 1 |
| 17 | Image-based visual servoing for nonholonomic mobile robots using epipolar geometry显示文摘 | Gian L M Giuseppe O Domenico P | 2007 | IEEE Transactions Robotics2007，23，1： | 1 |
| 18 | Modeling and simulation of a hydraulic breaker显示文摘 | Antonio G Domenico L F | 2005 | International Journal of Fluid Power2005，6，2： | 1 |
| 19 | Current status and epidemiological observation of Thelaxia calli paeda (Splrurlda , Thelaziidae) in dogs, cats and foxes in Italy: a 'coincidence' or a parasitic disease of the Old Contlnent显示文摘 | Domenico O Ezio F Riccardo P L | 2003 | Vet Parasitol2003，116，： | 1 |
| 20 | Correlation Between Nitrate Concentration in Groundwater and Parameters Affecting Aq- uifer Intrinsic Vulnerability显示文摘 | Laura D Domenico L Manuela L | 2008 | Environment Geology2008，55，3： | 1 |
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