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| 1 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 2 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 3 | Identification of a novel NCF- 1 (p47-phox) pseudogene not containing the signature GT deletion: significance for A47 chronic granulomatous disease carrier detection 显示文摘 | Heyworth PG Noack D Cross AR | 2002 | Blood2002，100，： | 1 |
| 4 | Cell culture of individual (1):development of wild-type culture显示文摘 | Cross D P | 1978 | Embryo Exp Marphol1978，45，16： | 1 |
| 5 | The Strength of Weak Ties you can Trust:The Mediating Role of Trust in Effective Knowledge Transfer显示文摘 | Levin D Z Cross R | | 0，，11： | 1 |
| 6 | Modified milk powder supplemented with immunostimulating whey protein concentrate,(IMUCARE) enhances immune function in mice显示文摘 | RUTHERFURD-MARKWICK K J JOHNSON D CROSS M L | | 0，，02： | 1 |
| 7 | Patient-specific instrumentation in total knee arthroplasty: a review显示文摘 | Nam D McArthur BA Cross MB | 2012 | J Knee Surg2012，25，3： | 1 |
| 8 | Assessment and improvement of the capabilities of a window correlator to model GPS multipath phase errors显示文摘 | Betaille D F Cross P A Euler H J | 2006 | IEEE Trans on Aerospace and Electronic Systems2006，42，2： | 1 |
| 9 | Effect of age, weaning and postweaning diet on small intestinal growth and jejunal morphology in young swine显示文摘 | CERA K R MAHAN D C CROSS R F | 1988 | J Anim Sci1988，66，2： | 1 |
| 10 | 显示文摘 | Jang S J Cross L E Wuttig M | 1990 | J Appl Phys1990，68，6： | 1 |
| 11 | Growth, carcass traits, and fatty acid pro- files of adipose tissues from steers fed whole cotton- seed 显示文摘 | HUERTA-LEIDENZ N O CROSS H R LUNT D K | 1991 | JAnim Sci1991，，69： | 1 |
| 12 | The Strength of Weak Ties You Can Trust: The Mediating Role of Trust in Effective Knowledge Transfer 显示文摘 | Levin D Z Cross R | 2004 | Management Science2004，50，11： | 1 |
| 13 | Laboratory recommendations for scoring deep molecular responses following treatment/'or chronic- myeloid leukemia显示文摘 | Cross NC White HE Colomer D | 2015 | Leukemia2015，29，5： | 1 |
| 14 | Polyvinyl alcohol particles sizeand suspension characteristerics显示文摘 | Moran C J Cross D T | 1995 | Am J Neuroradiol1995，16，6： | 1 |
| 15 | Physiological activity during a prolonged mental stress task : evidence for a shift in the control of pressor reactions 显示文摘 | Carroll D Cross G Harris MG | 1990 | Psychophysiology1990，4，3： | 1 |
| 16 | Graph matching with a dual-step EM algorithm显示文摘 | Cross A D J Hancock E R | 1998 | IEEE Transactions on Pattern Analysis and Machine Intelligence1998，20，11： | 1 |
| 17 | Investigations on the sex pheromone of pear leaf midge, Dasineura pyri (Bouche), and other gall midge pests of fruit crops显示文摘 | Amarawardana L Hall D Cross J | 2007 | IOBC-WPRS Bulletin2007，30，： | 1 |
| 18 | The strongth of weak ties you can trust:The mediating role of trust in effective knowledge transfer显示文摘 | Levin D Cross R | | 0，，11： | 1 |
| 19 | The strength of weak ties you can trust: The mediating role of trust in effective knowledge transfer显示文摘 | Levin D Z Cross R | 2004 | Management Science2004，50，11： | 1 |
| 20 | Thermochemical sulphate reduction (TSR):Experimental determination of reaction kinetics and implications of the observed reaction rates for petroleum reservoirs显示文摘 | MANNING D A C BOTTRELL S H WORDEN R H | 2004 | Org Geochem2004，35，4： | 1 |
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