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| 1 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 2 | Microstructures and Mechanical Properties of Fe-Mn-(Al, Si) TRIP/TWIP Steels显示文摘The mechanical properties and microstructure of two low carbon high manganese steels with 23.8% (No.1) and 33% (No.2) (mass percent) of manganese were investigated. The results showed that No.1 steel possesses high strength and high plasticity, and No.2 steel has a relatively high strength and extraordinary plasticity. The No.1 steel exhibits both TRIP (transformation induced plasticity) and TWIP (twin induced plasticity) effects during the deformation; while only TWIP effect appeared under the same deformation condition for No.2 steel. The comparison between the microstructures and mechanical properties of two steels was made, and the strengthening mechanisms were also analyzed. | DING Hua TANG Zheng-You LI Wei WANG Mei SONG Dan | 2006 | Journal of Iron and Steel Research(International)2006，13，6： | 31 |
| 3 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 4 | Correction of β-thalassemia mutant by base editor in human embryos显示文摘 | Puping Liang Chenhui Ding Hongwei Sun Xiaowei Xie Yanwen Xu Xiya Zhang Ying Sun Yuanyan Xiong Wenbin Ma Yongxiang Liu Yali Wang Jianpei Fang Dan Liu Zhou Songyang Canquan Zhou Junjiu Huang | 2017 | Protein & Cell2017，8，11： | 34 |
| 5 | 26mA cm^(-2) J_(sc) from organic solar cells with a low-bandgap nonfullerene acceptor显示文摘Nonfullerene-based organic solar cells(NFOSCs)have received great interest recently due to their higher performance and greater potential compared with fullerene-based solar cells[1].Power conversion efficiencies(PCEs)over 13% have been realized in single-junction NFOSCs[2].Compared with traditional fullerene acceptors,the greatest advantage of nonfullerene acceptors is their stronger light-harvesting capability in the visible and | Zuo Xiao Xue Jia Dan Li Shizhe Wang Xinjian Geng Feng Liu Junwu Chen Shangfeng Yang Thomas P.Russell Liming Ding | 2017 | Science Bulletin2017，62，22： | 28 |
| 6 | 食品中磷的检测方法显示文摘磷是人体内的重要元素之一,对人体生命活动有十分重要的作用,如何快速、简便、准确、灵敏地检测食品中磷的含量已经引起了世界各国的重视.本文总结了前人的研究工作,概述了近年来食品中总磷及有机磷农药的检测研究进展,分析了各种检测方法的优势和局限性,展望了未来该领域研究的发展趋势. | 卫敏 LIU RuiHai DING Liang CHENG WenLong XU JianFeng LUO Dan 刘钟栋 | 2010 | 中国科学:化学2010，40，7： | 24 |
| 7 | Preliminary results of Thymosin-a1 versus interferon-α treatment in patients with HBeAg negative and serum HBV DNA positive chronic hepatitis B显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | Lin Zhuang Jing You Bao Zhang Tang Su Ying Ding Kui Hua Yan Dan Peng Yan Mei Zhang Lu Zhang ~1Department of Hepatology,Kunming Third Municipal Peoples Hospital,Kunming 650041,Yunnan Province,China ~2Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 22 |
| 8 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 9 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 10 | Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens显示文摘The study of pathophysiological mecha nisms in huma n liver disease has bee n constrained by the in ability to expa nd primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be con verted to liver progenitor-like cells in vitro with defined chemical factors. Here we describe a protocol achieving efficient conversion of human primary hepatocytes into liver progenitor-like cells (HepLPCs) through delivery of developmentally relevant cues, including NAD +-dependent deacetylase SIRT1 signaling. These HepLPCs could be expanded sign ifica ntly duri ng in vitro passage. The expa nded cells can readily be con verted back into metabolically functional hepatocytes in vitro and upon tran splantati on in vivo. Under three-dime nsional culture conditions, differentiated cells gen erated from HepLPCs regai ned the ability to support infect io n or reactivatio n of hepatitis B virus (HBV). Our work dem on strates the utility of the con versi on betwee n hepatocyte and liver proge nitor-like cells for studying HBV biology and an tiviral therapies. These fin dings will facilitate the study of liver diseases and regenerative medicine. | Gong-Bo Fu Wei-Jian Huang Min Zeng Xu Zhou Hong-Ping Wu Chang-Cheng Liu Han Wu Jun Weng Hong-Dan Zhang Yong-Chao Cai Charles Ashton Min Ding Dan Tang Bao-Hua Zhang Yi Gao Wei-Feng Yu Bo Zhai Zhi-Ying He Hong-Yang Wang He-Xin Yan | 2019 | Cell Research2019，29，1： | 18 |
| 11 | Effective gene editing by high-fidelity base editor 2 in mouse zygotes显示文摘通过相应再结合的指向的点 mutagenesis 广泛地在基因研究被使用了并且为在病人修理引起疾病的变化保持可观的诺言。然而,象 mosaicism 那样的问题和低 mutagenesis 效率继续提出挑战到如此的途径的临床的申请。最近,一个基础编辑器() 在 cytidine (C) 脱氨基酶上造的系统和 CRISPR/Cas9 技术在植物,酵母,和人的房间为指向的点 mutagenesis 作为一个其他的方法被开发。然而,基础编辑器高效地在 deamination 窗口中把 C 变换成 thymidine (T) 是否指向了在鼠标胚胎的基础编辑,仍然保持不清楚是可行的。在这份报告,我们产生了基础编辑的一个修改高保真版本 2 (HF2-BE2 ) ,并且调查了它在老鼠胚胎编辑功效的底。我们发现 HF2-BE2 能高效地把 C 变换成 T,与直到在老鼠胚胎的 100% biallelic 变化效率。不同于 BE3, HF2-BE2 能在目标和非目标海滨上把 C 变换成 T,扩展基础编辑器的编辑范围。令人惊讶地,我们发现 HF2-BE2 能也使脱去氨基对 gRNA 有约束力的区域近似的 C。一起拿,我们的工作表明由基础编辑,和下划线在鼠标产生点变化的可行性小心地优化编辑系统以便消除近似地点的 deamination 的底的需要。 | Puping Liang Hongwei Sun Ying Sun Xiya Zhang Xiaowei Xie Jinran Zhang zhen Zhang Yuxi Chen Chenhui Ding Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang | 2017 | Protein & Cell2017，8，8： | 17 |
| 12 | Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade显示文摘The ubiquitin system is important for drug discovery,and the discovery of selective small-molecule inhibitors of deubiquitinating enzymes (DUBs) remains an active yet extremely challenging task. With a few exceptions,previously developed inhibitors have been found to bind the evolutionarily conserved catalytic centers of DUBs,resulting in poor selectivity. The small molecule IU1 was the first-ever specific inhibitor identified and exhibited surprisingly excellent selectivity for USP14 over other DUBs. However,the molecular mechanism for this selectivity was elusive. Herein,we report the high-resolution co-crystal structures of the catalytic domain of USP14 bound to IU1 and three IU1 derivatives. All the structures of these complexes indicate that IU1 and its analogs bind to a previously unknown steric binding site in USP14,thus blocking the access of the C-terminus of ubiquitin to the active site of USP14 and abrogating USP14 activity. Importantly,this steric site in USP14 is very unique,as suggested by structural alignments of USP14 with several known DUB X-ray structures. These results,in conjunction with biochemical characterization,Indicate a coherent steric blockade mechanism for U5P14 inhibition by compounds of the IU series. In light of the recent report of steric blockade of USP7 by FT671,this work suggests a potential generally applicable allosteric mechanism for the regulation of DUBs via steric blockade,as showcased by our discovery of IU1-248 which is 10-fold more potent than IU1. | Yiwei Wang Yuxuan Jiang Shan Ding Jiawang Li Ningjing Song Yujing Ren Danning Hong Cai Wu Bin Li Feng Wang Wei He Jiawei Wang Ziqing Mei | 2018 | Cell Research2018，28，12： | 15 |
| 13 | Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia显示文摘The disturbance of maternal immune tolerance to a semiallogeneic fetus is recognized as one of the key pathologies of preeclampsia(PE),in which an imbalance between the inflammation-limiting regulatory T cells(Tregs)and the inflammationmediating Th17 cells plays an essential role.Previously,we reported that the abnormal upregulation of tetraspannin CD81 in trophoblast cells(fetal component)participated in the pathogenesis of PE.However,as one of the potential immune regulatory molecules,whether CD81 induces PE by interfering with the balance of the maternal immune system has not yet been clarified.Thus,we investigated the relationship between the upregulation of CD81 in trophoblast cells and the imbalance of Treg and Th17 cells in mothers.Here,we demonstrated that upregulation of CD81 in trophoblast cells was accompanied by a decrease in Treg cells and an increase in Th17 cells in both the basal plate(placental maternal side)and peripheral blood of patients with PE.In vitro culture of naïve T cells with medium from the CD81-overexpressing trophoblast cell line HTR-8 resulted in enhanced differentiation of T cells into Th17 cells and decreased the formation of Tregs,which was dependent on the paracrine signaling of IL-6 in trophocytes,induced by CD81.In a CD81-induced PE rat model,we found a significant shift of T cell differentiation towards Th17 cells,and administration of IL-6 antibody mitigated the PE phenotype and the imbalance of the Treg/Th17 cells.These results define a vital regulatory cascade involving trophocyte-derived CD81,IL-6,and maternal Treg/Th17 cells in the pathogenesis of PE and suggests new therapeutic approaches based on CD81 and IL-6 downregulation to prevent human PE. | Hailin Ding Yimin Dai Yi Lei Zhiyin Wang Dan Liu Ruotian Li Li Shen Ning Gu Mingming Zheng Xiangyu Zhu Guangfeng Zhao Yali Hu | 2019 | Cellular & Molecular Immunology2019，16，3： | 15 |
| 14 | Engineering Introns to Express RNA Guides for Cas9- and Cpfl-Mediated Multiplex Genome Editing显示文摘定期聚类 interspaced 短 palindromic 重复(CRISPR ) 系统为指向的 DNA 作为革命站台出现了。这个系统使用一个地点特定的 RNA 指南指导一个 CRISPR 受动器(例如, Cas9 和 Cpf1 ) 到一个 DNA 目标。这里,我们详细描述一般策略同时从 Cas9 和 Cpf1 的 introns 表示多重指南 RNA (gRNA ) 和 CRISPR RNA (crRNA ) 。这个方法利用处理系统或 Cpf1 的 crRNA 处理活动劈开包含 tRNA-gRNA polycistron 或 crRNA-crRNA 数组的拼接的 intron 的内长的 tRNA。我们证明 tRNA-gRNA intron 能作为一基因与 Cas9 熔化。如此的混合基因能用一个聚合酶 II 倡导者被表示,并且在同时指向多重地点展出了高效率和坚韧性。我们 ? 也在调停 Cpf1 的染色体用 intronic tRNA-crRNA 和 crRNA-crRNA 数组编辑实现了这策略。有趣地,包含 Cpf1 和 intronic crRNA 的混合基因与常规 Cpf1 向量相比穿展出显著地增加的效率。一起拿,这研究介绍一个方法从一混合基因表示 CRISPR 试剂增加编辑染色体的效率和能力。由于它的简洁和通用性,这个方法能广泛地被用来在优核质开发复杂 CRISPR 工具。 | Dan Ding Kaiyuan Chen Yuedan Chen Hong Li Kabin Xie | 2018 | Molecular Plant2018，11，4： | 14 |
| 15 | Enalapril inhibits tubulointerstitial inflammation and NLRP3 inflammasome expression in BSA-overload nephropathy of rats显示文摘 | Li-hong DING Dan LIU Min XU Hong LIU Min WU Ri-ning TANG Lin-li LV Kun-ling MA Bi-cheng LIU | 2014 | Acta Pharmacologica Sinica2014，35，10： | 11 |
| 16 | Interface engineering gifts CsPbI2.25Br0.75 solar cells high performance显示文摘Organic-inorganic halide perovskite (ABX3) solar cells (PSCs)have made great progress in recent years [1]. The power conversion efficiency (PCE) has increased up to 25.2%(NREL Best Research-Cell Efficiency Chart, http://gffzz8798726073dc471cs6kuxwqpxv9kv6k0f.ffgz.tsg.suse.edu.cn/pv/cell-efficiency.html, Accessed August 2019). However, they suffer from poor thermal stability due to the volatile A-site organic cations. | Zhimin Fang Xianyi Meng Chuantian Zuo Dan Li Zuo Xiao Chenyi Yi Mingkui Wang Zhiwen Jin Shangfeng Yang Liming Ding | 2019 | Science Bulletin2019，64，23： | 11 |
| 17 | Chemical and Isotopic Characteristics of the Water and Suspended Particulate Materials in the Yangtze River and Their Geological and Environmental Implications显示文摘The chemical and isotopic characteristics of the water and suspended particulate materials(SPM) in the Yangtze River were investigated on the samples collected from 25 hydrological monitoring stations in the mainsteam and 13 hydrological monitoring stations in the major tributaries during 2003 to 2007. The water samples show a large variation in both δD( 30‰ to 112‰) and δ18O( 3.8‰ to 15.4‰) values. Both δD and δ18O values show a decrease from the river head to the Jinsha Jiang section and then increase downstream to the river mouth. It is found that the oxygen and hydrogen isotopic compositions of the Yangtze water are controlled by meteoric precipitation, evaporation, ice(and snow) melting and dam building. The Yangtze SPM concentrations show a large variation and are well corresponded to the spatial and temporal changes of flow speed, runoff and SPM supply, which are affected by the slope of the river bed, local precipitation rate, weathering intensity, erosion condition and anthropogenic activity. The Yangtze SPM consists of clay minerals, clastic silicate and carbonate minerals, heavy minerals, iron hydroxide and organic compounds. From the upper to lower reaches, the clay and clastic silicate components in SPM increase gradually, but the carbonate components decrease gradually, which may reflect changes of climate and weathering intensity in the drainage area. Compared to those of the upper crust rocks, the Yangtze SPM has lower contents of SiO2, CaO, K2 O and Na2 O and higher contents of TFe2 O3 and trace metals of Co, Ni, Cu, Zn, Pb and Cd. The ΣREE in the Yangtze SPM is also slightly higher than that of the upper crust. From the upper to lower reaches, the CaO and MgO contents in SPM decrease gradually, but the SiO2 content increases gradually, corresponding to the increase of clay minerals and decrease of the carbonates. The δ30SiSPM values( 1.1‰ to 0.3‰) of the Yangtze SPM are similar to those of the average shale, but lower than those of the granite rocks( 0.3‰ to 0.3‰), reflecting the effect of silicon isotope fractionation in silicate weathering process. The δ30SiSPM values of the Yangtze SPM show a decreasing trend from the upper to the middle and lower reaches, responding to the variation of the clay content. The major anions of the river water are HCO 3, SO 4 2, Cl, NO 3, SiO 4 4 and F and the major cations include Ca2+, Na+, Mg2+, K+ and Sr2+. The good correlation between HCO3-content and the content of Ca2+may suggest that carbonate dissolution is the dominate contributor to the total dissolved solid(TDS) of the Yangtze River. Very good correlations are also found among contents of Cl, SO4 2, Na+, Mg2+, K+and Sr2+, indicating the important contribution of evaporite dissolution to the TDS of the Yangtze River. High TDS contents are generally found in the head water, reflecting a strong effect of evaporation in the Qinghai-Tibet Plateau. A small increase of the TDS is generally observed in the river mouth, indicating the influence of tidal intrusion. The F and NO3 contents show a clear increase trend from the upstream to downstream, reflecting the contribution of pesticides and fertilizers in the Chuan Jiang section and the middle and lower reaches. The DSi shows a decrease trend from the upstream to downstream, reflecting the effect of rice and grass growth along the Chuan Jiang section and the middle and lower reaches. The dissolved Cu, Zn and Cd in the Yangtze water are all higher than those in world large rivers, reflecting the effect of intensive mining activity along the Yangtze drainage area. The Yangtze water generally shows similar REE distribution pattern to the global shale. The δ30SiDiss values of the dissolved silicon vary from 0.5‰ to 3.7‰, which is the highest among those of the rivers studied. The δ30SiDiss values of the water in the Yangtze mainsteam show an increase trend from the upper stream to downstream. Its DSi and δ30SiDiss are influenced by multiple processes, such as weathering process, phytolith growth in plants, evaporation, phytolith dissolution, growth of fresh water diatom, adsorption and desorption of aqueous monosilicic acid on iron oxide, precipitation of silcretes and formation of clays coatings in aquifers, and human activity. The δ34SSO4 values of the Yangtze water range from 1.7‰ to 9.0‰. The SO4 in the Yangtze water are mainly from the SO4 in meteoric water, the dissolved sulfate from evaporite, and oxidation of sulfide in rocks, coal and ore deposits. The sulfate reduction and precipitation process can also affect the sulfur isotope composition of the Yangtze water. The87Sr/86Sr ratios of the Yangtze water range from 0.70823 to 0.71590, with an average value of 0.71084. The87Sr/86Sr ratio and Sr concentration are primary controlled by mixing of various sources with different87Sr/86Sr ratios and Sr contents, including the limestone, evaporite and the silicate rocks. The atmospheric precipitation and anthropogenic inputs can also contribute some Sr to the river. The δ11B values of the dissolved B in the Yangtze water range from 2.0‰ to 18.3‰, which is affected by multifactors, such as silicate weathering, carbonate weathering, evaporite dissolution, atmospheric deposition, and anthropogenic inputs. | DING Tiping GAO Jianfei TIAN Shihong SHI Guoyu CHEN Feng WANG Chengyu LUO Xurong HAN Dan | 2014 | Acta Geologica Sinica(English Edition)2014，88，1： | 10 |
| 18 | Effect of Integrated Chinese and Western Medicine Therapy on Severe Hand, Foot and Mouth Disease: A Prospective, Randomized, Controlled Trial显示文摘Objective: To evaluate the efficacy and safety of Chinese medicine(CM) plus Western medicine(WM) in the treatment of pediatric patients with severe hand, foot and mouth disease(HFMD) by conducting a prospective, controlled, and randomized trial. Methods: A total of 451 pediatric patients with severe HFMD were randomly assigned to receive WM therapy alone(224 cases, WM therapy group) or CM [Reduning Injection(热毒宁注射液) or Xiyanping Injection(喜炎平注射液)] plus WM therapy(227 cases, CM plus WM therapy group) for 7–10 days, according to a web-based randomization system. The primary outcome was fever clearance time, which was presented as temperature decreased half-life time. The secondary outcomes included the rate of rash/herpes disappearance within 120 h, as well as the rate for cough, runny nose, lethargy and weakness, agitation or irritability, and vomiting clearance within 120 h. The drug-related adverse events were also recorded. Results: The temperature decreased half-life time was 40.4 h in the WM therapy group, significantly longer than 27.2 h in the CM plus WM therapy group(P<0.01). Moreover, the rate for rash/herpes disappearance within 120 h was 43.6%(99/227) in the CM plus WM therapy group, significantly higher than 29.5%(66/224) in the WM therapy group(P<0.01). In addition, the rate for cough, lethargy and weakness, agitation or irritability disappearance within 120 h was 32.6%(74/227) in the CM plus WM therapy group, significantly higher than 19.2%(43/224) in the WM therapy group(P<0.01). No drug-related adverse events were observed during the course of the study. Conclusions: The combined CM and WM therapy achieved a better therapeutic efficacy in treating severe HFMD than the WM therapy alone. Reduning or Xiyanping Injections may become an important complementary therapy to WM for relieving the symptoms of severe HFMD. | LI Xiu-hui LI Shuang-jie XU Yi WEI Dan SHI Qing-sheng ZHU Qing-xiong YANG Tong DING Jian-bo TIAN Yi-mei HUANG Ji-han WANG Kun WEN Tao ZHANG Xi | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 10 |
| 19 | Outpatient versus inpatient laparoscopic cholecystectomy:a single center clinical analysis显示文摘BACKGROUND:Outpatient laparoscopic cholecystectomy (OPLC) developed in the United States and other developed countries as one of the fast-track surgeries performed in ambulatory centers.However,this practice has not been installed as a routine practice in the major general hospitals and medical centers in China.We designed this case-control study to evaluate the feasibility,benefits,and safety of OPLC.METHODS:Two hundred patients who had received laparoscopic cholecystectomy for various benign gallbladder pathologies from April 2007 to December 2008 at Jinling Hospital of Nanjing University School of Medicine were classified into two groups:OPLC group (100 patients),and control group (100),who were designated for inpatient laparoscopic cholecystectomy (IPLC).Data were collected for age,gender,indications for surgery,American Society of Anesthesiology (ASA) class,operative time,blood loss during surgery,length of hospitalization,and intra-and post-operative complications.The expenses of surgery and in-hospital care were calculated and analyzed.The operative procedures and instrumentation were standardized for laparoscopic cholecystectomy,and the procedures were performed by two attending surgeons specialized in laparoscopic surgery.OPLC was selected according to the standard criteria developed by surgeons in our hospital after review.Reasons for conversion from laparoscopic to open cholecystectomy were recorded and documented.RESULTS:One hundred patients underwent IPLC following the selection criteria for the procedure,and 99% completed the procedure.The median operative time for IPLC was 24.0 minutes,blood loss was 16.2 ml,and the time for resuming liquid then soft diet was 10.7 hours and 22.0 hours,respectively.Only one patient had postoperative urinary infection.The mean hospital stay for IPLC was 58.2 hours,and the cost for surgery and hospitalization was 8770.5 RMB yuan on average.Followup showed that 90% of the patients were satisfied with the procedure.In the OPLC group,99% of the patients underwent the procedure with a median operative time of 21.6 minutes and bleeding of 14.7 ml.The patients took liquid 11.3 hours then soft diet 20.1 hours after surgery.The mean postoperative hospital stay was 28.5 hours.In this group,89% of the patients were discharged within the first 24 hours,and the remaining 11% were released within 48 hours after surgery.Two patients developed local complications.The cost for surgery and hospitalization was 7235.7 RMB yuan,which was 17.5% less than that in the IPLC group.At follow-up,94% of the patients were satisfied with the surgery and short hospital stay.CONCLUSIONS:OPLC can effectively treat a variety of benign,non-acute gallbladder diseases with shortened waiting time and postoperative hospital stay.OPLC benefits the hospital with a rapid bed turnover rate,and reduces cost for surgery and hospitalization. | Ji, Wu Ding, Kai Li, Ling-Tang Wang, Dan Li, Ning Li, Jie-Shou | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 9 |
| 20 | The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure显示文摘Necroptosis 是在各种各样的疾病被含有的调整房间死亡的一种类型。交往受体的蛋白质 3 (RIP3 ) , RIP 家庭的一个成员,是 necroptotic 小径的一个重要调停人。在由 caspase-8 的 Asp328 的 RIP3 的劈开废除 RIP3 的 kinase 活动,它为 necroptosis 是批评的。而且, RIP3 是显著地 upregulated 在尖锐高 intra 眼睛的压力和氧葡萄糖剥夺的早阶段期间。在这研究, RIP3 的效果在提高的静水力学的压力(EHP ) 期间被调查, caspase-8 通过调整了 RIP3 劈开的可能的机制被探索。流动 cytometry 分析表明导致 EHP 的坏死的网膜的中心房间 5 的数字(RGC-5 ) 房间被减少在以后 RIP3 击倒。而且,在正常 RGC-5 房间的 malondialdehyde (MDA ) 层次和肝糖 phosphorylase (PYGL ) 活动比在在 EHP 以后的 RIP3 击倒的房间的那些高得多。导致 EHP 的 RGC-5 坏死显著地与 butylated hydroxyanisole (BHA ) 在处理以后被减少,反应的氧种类(ROS ) scavenger。MDA 层次和 PYGL 活动比在有在 EHP 以后的 caspase-8 抑制的房间的那些在正常 RGC-5 房间是更低的。西方的污点分析证明 RIP3 劈开产品是在有 caspase-8 抑制的房间的 upregulated。另外,流动 cytometry 分析表明导致 EHP 的坏死的 RGC-5 房间的数字在 caspase-8 抑制以后被增加。我们的结果建议 RGC-5 necroptosis 追随者 EHP 被 RIP3 通过 PYGL 活动和随后的 ROS 累积的正式就职调停。因此, caspase-8 可以经由 RIP3 劈开参予 RGC-5 necroptosis 的规定。 | Lei Shang Wei Ding Na Li Lvshuang Liao Dan Chen Jufang Huang Kun Xiong | 2017 | Acta Biochimica et Biophysica Sinica2017，49，2： | 9 |
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