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| 1 | From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world显示文摘Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma. | Dimitrios Dimitroulis Christos Damaskos Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis Antonios Athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis | 2017 | World Journal of Gastroenterology2017，23，29： | 44 |
| 2 | Role of surgery in colorectal liver metastases:Too early or too late?显示文摘As colorectal cancer and colorectal liver metastases become a serious public health problem,new treatment modalities are needed in order to achieve better results. In the last decade there has been very important progress in oncology,with new and more effective chemotherapeutic agents administered alone or in combination improving the resectability rate in up to 40%of patients with colorectal liver metastases.Advances in interventional radiology,in particular,with the use of portal vein embolization and radiofrequency thermal ablation are new strategies allowing major liver resections and treatment of small liver metastases or early recurrences.Surgery,however,remains the gold standard strategy with intention to treat.In this review article we will describe the advanced role of surgery in the multidisciplinary approach to colorectal liver metastases,and the clinical problems the liver surgeon has to deal with,such as theresectability of the metastases,the presence of bilobar liver lesions and extrahepatic disease,the impact of chemotherapy in already resectable liver metastases,the problem of vanishing metastases after chemotherapy and the dilemma of staged or combined liver and colon operations and which organ first in the clinical scenario of synchronous colorectal liver metastases. | Dimitrios Dimitroulis Nikolaos Nikiteas Theodore Troupis Dimitrios Patsouras Panayiotis Skandalakis Gregory Kouraklis | 2010 | World Journal of Gastroenterology2010，16，28： | 5 |
| 3 | Hepatocellular carcinoma in patients co-infected with hepatitis C virus and human immunodeficiency virus显示文摘Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) share a common route of transmission so that about one third of HIV infected individuals show HCV coinfection. Highly active antiretroviral therapy has offered a longer and better life to infected patients. While has removed AIDS-related diseases from the list of most common causes of death their place has been taken by complications of HCV infection, such as cirrhosis, end stage liver disease and hepatocellular carcinoma (HCC). HIV/HCV co-infection requires complex management, especially when HCC is present. Co-infected patients with HCC undergo the same therapeutic protocol as their mono-infected counterparts, but special issues such as interaction between regimens, withdrawal of therapy and choice of immunosuppressive agents, demand a careful approach by specialists. All these issues are analyzed in this minireview. | Dimitrios Dimitroulis Serena Valsami Eleftherios Spartalis Emmanuel Pikoulis Gregory Kouraklis | 2013 | World Journal of Hepatology2013，5，6： | 4 |
| 4 | Indications,limitations and maneuvers to enable extended hepatectomy:Current trends显示文摘The liver is a solid organ with a wide variety of primary benign or malignant tumors as well as metastatic lesions.Surgical resection of these tumors remains the only curative modality.Several limitations,however,do not allow the performance of these operations.This review evaluates the indications and limitations regarding these extended hepatic resections,as well as describing all the manipulations that increase the candidates for such operations.A thorough review of the literature was performed in order to define indications for extended hepatectomy,as well as to present all methods that contribute to increasing the volume of the future remnant liver.The role of portal vein ligation,portal vein embolization,two-stage hepatectomy,and in situ liver transection are evaluated in the setting of indications and results.Extended hepatectomies are a necessity due to oncological reasons.All methods developed in order to increase the volume of the remnant liver are safe and efficient.in situ liver transection is a novel and revolutionary two-step procedure for extended hepatic resections.Further clinical studies are required to estimate long-term results and the oncological basis of this technique. | Dimitrios Dimitroulis Petros Tsaparas Serena Valsami Dimitrios Mantas Eleftherios Spartalis Charalampos Markakis Gregory Kouraklis | 2014 | World Journal of Gastroenterology2014，20，24： | 4 |
| 5 | Barrett's esophagus with high-grade dysplasia:Focus on current treatment options显示文摘High-grade dysplasia(HGD) in Barrett's esophagus(BE) is the critical step before invasive esophageal adenocarcinoma.Although its natural history remains unclear,an aggressive therapeutic approach is usually indicated.Esophagectomy represents the only treatment able to reliably eradicate the neoplastic epithelium.In healthy patients with reasonable life expectancy,vagal-sparing esophagectomy,with associated low mortality and low early and late postoperative morbidity,is considered the treatment of choice for BE with HGD.Patients unfit for surgery should be managed in a less aggressive manner,using endoscopic ablation or endoscopic mucosal resection of the entire BE segment,followed by lifelong surveillance.Patients eligible for surgery who present with a long BE segment,multifocal dysplastic lesions,severe reflux symptoms,a large fixed hiatal hernia or dysphagia comprise a challenging group with regard to the appropriate treatment,either surgical or endoscopic. | Leonidas Lekakos Nikolaos P Karidis Dimitrios Dimitroulis Christos Tsigris Gregory Kouraklis Nikolaos Nikiteas | 2011 | World Journal of Gastroenterology2011，17，37： | 2 |
| 6 | Mechanistic insights of rapid liver regeneration after associating liver partition and portal vein ligation for stage hepatectomy显示文摘AIM To highlight the potential mechanisms of regeneration in the Associating Liver Partition and Portal vein ligation for Stage hepatectomy models(clinical and experimental) that could unlock the myth behind the extraordinary capability of the liver for regeneration,which would help in designing new therapeutic options for the regenerative drive in difficult setup,such as chronic liver diseases. Associating Liver Partition and Portal vein ligation for Stage hepatectomy has been recently advocated to induce rapid future liver remnant hypertrophy that significantly shortens the time for the second stage hepatectomy. The introduction of Associating Liver Partition and Portal vein ligation for Stage hepatectomy in the surgical armamentarium of therapeutic tools for liver surgeons represented a real breakthrough in the history of liver surgery. METHODS A comprehensive literature review of Associating Liver Partition and Portal vein ligation for Stage hepatectomy and its utility in liver regeneration is performed. RESULTS Liver regeneration after Associating Liver Partition and Portal vein ligation for Stage hepatectomy is a combination of portal flow changes and parenchymal transection that generate a systematic response inducing hepatocyte proliferation and remodeling. CONCLUSION Associating Liver Partition and Portal vein ligation for Stage hepatectomy represents a real breakthrough in the history of liver surgery because it offers rapid liver regeneration potential that facilitate resection of liver tumors that were previously though unresectable. The jury is still out though in terms of safety,efficacy and oncological outcomes. As far as Associating Liver Partition and Portal vein ligation for Stage hepatectomy-induced liver regeneration is concerned,further research on the field should focus on the role of nonparenchymal cells in liver regeneration as well as on the effect of Associating Liver Partition and Portal vein ligation for Stage hepatectomy in liver regeneration in the setup of parenchymal liver disease. | Demetrios Moris Spyridon Vernadakis Alexandros Papalampros Michail Vailas Nikolaos Dimitrokallis Athanasios Petrou Dimitrios Dimitroulis | 2016 | World Journal of Gastroenterology2016，22，33： | 2 |
| 7 | Comparison of cisplatin-paclitaxel combination versus cisplatin-etoposide in pa- tients with small-cell lung cancer: A Phase Ⅲ study 显示文摘 | Dimitroulis J Rapti A Stathopoulos GP | 2008 | Oncol Rep2008，20，4： | 1 |
| 8 | Noninvasive measurement of mean alveolar carbon dioxide tension and Bohr's dead space during tidal breathing显示文摘 | Koulouris NG Latsi P Dimitroulis J | | 0，，06： | 1 |
| 9 | Management of fractured mandibles without the use of intermaxillary wire fixation显示文摘 | | 2002 | J Oral Maxillofac Surg2002，60，12： | 1 |
| 10 | Evolution of non-small cell lung cancer chemotherapy: review显示文摘 | Dimitroulis J StathopoulosG P | 2005 | Oneol Rep2005，13，5： | 1 |
| 11 | Comparison of the push-outstrength of two fiber post systems dependent on different types ofresin cements显示文摘 | Dimitrouli M Geurtsen W Liihrs AK | 2012 | Clin Oral Investig2012，16，3： | 1 |
| 12 | Vascular complications in renal transplantation : a single-center experience in 1367 renal transplantations and review of the literature 显示文摘 | Dimitroulis D Bokos J Zavos G | 2009 | Transplant Proc2009，41，5： | 1 |
| 13 | Comparison of the push-out strength of two fiber post systems dependent on different types of resin cements显示文摘 | Dimitrouli M Geurtsen W Luhrs AK | 2012 | Clin Oral Investig2012，16，3： | 1 |
| 14 | Management of fractured mandibles without the use of intermaxillary wire fixation 显示文摘 | Dimitroulis G | 2002 | J Oral Maxillo- fac Surg2002，60，12： | 1 |
| 15 | Comparison of cisplatin-pa clitaxel combination versus cisplatin-etoposide in patients with small-cell lung cancer:a PhaseⅢstudy显示文摘 | Dimitroulis J Rapti A Stathopoulos GP | 2008 | Oncol Rep2008，20，4： | 1 |
| 16 | Current trends in platelet transfusions practice: The role of ABO-RhD and hu man leukocyte antigen incompatibility显示文摘 | Valsami S Dimitroulis D Gialeraki A | 2015 | Asian J Transfus Sci2015，9，2： | 1 |
| 17 | Management of fractured mandibles without the use of intermaxillary wire fixation显示文摘 | | 2002 | J Oral Maxillofac Surg2002，60，12： | 1 |
| 18 | Im- munological HCV- associated thrombocytopenia; short review 显示文摘 | DIMITROULIS D VALSAMI S STAMOPOULOS P | 2012 | Clin Dev Immunol2012，37，： | 1 |
| 19 | Temporomandibular disorders:a clinical update显示文摘 | Dimitroulis G | 1998 | BMJ1998，317，7152： | 1 |
| 20 | Systematic re- view and meta-analysis of interferon after curative treatment of hepatoeellular carcinoma in patients with viral hepatitis显示文摘 | Breitenstein S Dimitroulis D Petrowsky H | 2009 | Br J Surg2009，96，9： | 1 |
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