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| 1 | Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms显示文摘The possible relationship between diabetes mellitus (DM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field were thoroughly reviewed. Common risk factors, such as obesity, sedentary lifestyle, and Western diet between DM and CRC, led to the theory that DM might be a causal agent for CRC development. Various studies have connected type 2 DM and CRC, either proximal or distal, in both sexes. Additionally, chronic insulin treatment has been linked with increased colorectal tumor risk among type 2 diabetic patients. Interestingly, elevated hemoglobin A1c has been proven to be an independent predictor of aggressive clinical behavior in CRC patients. These mechanisms include the insulin-like growth factor-hyperinsulinemia theory and the participation of oncogenic intracellular signaling pathways. Furthermore, it has been proposed that Cox-2 inhibitors might have a role in decreasing the incidence of CRC. Finally, the use of statins to reduce the risk for colon cancer in patients with diabetes has remained controversial. Diabetic patients over 50 should receive counseling regarding their elevated risk for CRC, and screening colonoscopy should be recommended before initiating insulin therapy. However, there are no current guidelines, and this strategy is not yet applicable to some countries, as the corresponding risk would not allow screening colonoscopy to be adopted. There is strong evidence to indicate that DM is a causal agent for CRC development. This conclusion provides new impetus for re-evaluating CRC screening worldwide. | Olga Giouleme Michael D Diamantidis Marios G Katsaros | 2011 | World Journal of Gastroenterology2011，17，4： | 15 |
| 2 | Purification and characterization of the first bacterial laccase in the rhizospheric bacterium Azospirilum lipoferum 显示文摘 | Diamantidis G J Effosse A Povira P | 2000 | Soil Biology and Biochemistry2000，32，： | 1 |
| 3 | The effect of heat treatment on quality retention of fi'esh-cut peach显示文摘 | Kounaras A Diamantidis G Sfakiotakis E | 2008 | Postharvest Biology and Tectmology2008，48，： | 1 |
| 4 | Cell wall cation composition and distribution in chilling-injured nectarine fruit 显示文摘 | Manganaris G A Vasilakakis M Diamantidis Q | 2005 | Postharvest Biol Technol2005，37，1： | 1 |
| 5 | Pofier Pll-cation and ehalt tefization of the first bacterial laccaseinthe rhizospheric bacterium Azospum 16: of erum显示文摘 | Diamantidis G Efosse A | 2000 | Soil Bioi Biochem2000，32，7： | 1 |
| 6 | Diverse metabolism of cell wall components of melting and nonmelting peach genotypes during ripening after harvest or cold storage 显示文摘 | MANGANARIS G A VASILAKAKIS M DIAMANTIDIS G MIGNANI I | 2006 | Journal of the Science of Food and Agriculture2006，86，： | 1 |
| 7 | Purification and characterization of the first bacterial laccase in the rhizospheric bacterium Azospirillum lipoferum显示文摘 | Diamantidis G Effosse A Potier P | 2000 | Soil Biology & Biochemistry2000，32，： | 1 |
| 8 | Theeffect of posthafvest calcium application oh tissue calciumconcentration,quality attributes,incidence of flesh browningand cell wall physicochemical aspects of peach fruits显示文摘 | Manganaris G A Vasilakakis M Diamantidis G | 2007 | FoodChem2007，100，： | 1 |
| 9 | Cell wall physicochemical aspects of peach fruit related to internal breakdown symptoms显示文摘 | Manganaris G A Vasilakakis M Diamantidis G | 2013 | Postharvest Biology and Technology2013，39，1： | 1 |
| 10 | Determination of malathion, coumaphos and fluvalinate residues in honey by gas chromatography with nitrogen phosphorus or electron capture detectors显示文摘 | MENKISSOGLU-SPIROUDI U DIAMANTIDIS G GEORGIOU V E | 2000 | Journal of AOAC International2000，83，1： | 1 |
| 11 | Purification and characterization of the first bacterial laccase in the rhizospheric bacterium Azospirillum lipoferum显示文摘 | Diamantidis G Effosse A Potier P | 2000 | Soil Biol Biochem2000，32，： | 1 |
| 12 | Effect of calcium additives on physicochemieal aspects of cell wall pectin and sensory attributes of canned peach (Prunus persica(L) Batseh ev Andross) 显示文摘 | Manganaris G A Vasilakakis M Diamantidis G | 2005 | J Sei Food Agric2005，85，： | 1 |
| 13 | Purification and characterization of the first bacterial laccase in the rhizospheric bacterium Azospirillum lipoferum显示文摘 | Effosse A Potier P | 2001 | Soil Biol Biochem2001，32，： | 1 |
| 14 | Purification and characterization of the first bacteriallae- case in the rhizospheric bacterium Azospirillum lipoferum 显示文摘 | DIAMANTIDIS G EFFOSSE A POTIER P | 2000 | Soil Biology & Biochemistry2000，32，7： | 1 |
| 15 | The effect of postharvest calcium application on tissue calcium concentration, quality attributes, incidence of flesh browning and cell wall physicochemical aspects of peach fruits显示文摘 | Manganaris G A Vasilakakis M Diamantidis G | 2007 | Food Chem2007，100，： | 1 |
| 16 | The effect of postharvest calcium application on tissue calcium concentration, quality attributes incidence of flesh browning and cell wall physicoehemieal aspects of peach fruits 显示文摘 | MANGANARIS G A VASILAKAKIS M DIAMANTIDIS G | 2007 | Food Chemistry2007，100，： | 1 |
| 17 | Effect of post-harvest calcium treatments on the physicochemical properties of cell wall pectin in nectarine fruit during ripening after harvest or cold storage 显示文摘 | MANGANARIS G A VASILAKAKIS M DIAMANTIDIS G | 2005 | Journal of Horticultural Science and Biotechnology2005，80，5： | 1 |
| 18 | Hydrogen peroxide and nitric oxide-induced systemic antioxidant primelike ac- tivity under NaCl-stress and stress-free conditions incitrus plants显示文摘 | Tanou G Molassiotis A Diamantidis G | 2009 | Journal of Plant Physiology2009，166，17： | 1 |
| 19 | Purification and characterization of the first bacterial laccase in the rhizospheric bacterium Azosprillum lipoferum显示文摘 | Diamantidis G Effosse A Potier P | 2000 | Soil Biology and Biochemistry2000，32，7： | 1 |
| 20 | Corynebacterium jeikeium bacteremia in a hemodialyzedpatient显示文摘 | lfantidou A M Diamantidis M D Tseliki G | 2010 | Int J Infect Dis2010，14，3： | 1 |
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