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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | The role of motivation in visitor satisfaction:Empirical evidence in rural tourism显示文摘 | Devesa M Laguna M Palacios A | | 0，，04： | 1 |
| 3 | Organoarseni- cal species contents in fresh and processed seafood products 显示文摘 | Suner M A Devesa V Clemente M J | 2002 | J Agrie Food Chem2002，，50： | 1 |
| 4 | The role of motivation in visitor satisfaction:empirical evidence in rural tourism显示文摘 | DEVESA M LAGUNA M PALACIOS A | 2009 | Tourism Management2009，30，3： | 1 |
| 5 | Gas production by almond shell pyrolysis at high temperature显示文摘 | MARCILLA A DEVESA J | 1994 | Journal of Analytical and Applied Pyrolysis1994，28，1： | 1 |
| 6 | Artificial anal sphincter:complications and functional results of a large personal series显示文摘 | Devesa JM Rey A Hervas PL | 2002 | Dis Colon Rectum2002，45，9： | 1 |
| 7 | Speciation of cationic arsenic species in seafood by coupling liquid chromatogramphy with hydride generateon atomic fluorescence detection显示文摘 | SUNER M A DEVESA V RIVAS I | 2000 | J Anal At Spectrom2000，15，： | 1 |
| 8 | The role of motivation in visitor satisfaction:Empirical evidence in rural tourism显示文摘 | Devesa M Laguna M Palacios A | 2010 | Tourism Management2010，31，4： | 1 |
| 9 | Effects of the combination of starters and enzymes in regulating bread quality and self-life显示文摘 | ANAYA M A DEVESA A ANDREU P | 1998 | Food Science and Technology International1998，4，6： | 1 |
| 10 | Organoarsenical species contents in fresh and processed seafood products 显示文摘 | Suner M A Devesa V Clemente M J etal | 2002 | J Agric Food Chem2002，50，： | 1 |
| 11 | Ulcerative skin and fin lesions in reared turbot,Scophthalmus maximus显示文摘 | Devesa S Barja J L Toranzo A E | 1989 | Journal of Fish Diseases1989，，12： | 1 |
| 12 | First report of vibriosis in turbot (Scophthalmus maximus) cultured in North- western Spain显示文摘 | Devesa S Toranzo A E Barja J I | 1985 | Fish and Shellfish Pathology1985，，1： | 1 |
| 13 | Kinetic study of transformations of arsenie species during heat treatment显示文摘 | Devesa V Martinez A Stifler MA | 2001 | J Agrie Food Chem2001，49，： | 1 |
| 14 | Kinetic study of transformations of arsenic species during heat treatment显示文摘 | Devesa V Marttnez A Suner MA | 2001 | J Agile Food Chem2001，49，5： | 1 |
| 15 | Retinoblastoma incidence and sunlight exposure显示文摘 | JEMAL A Devesa S S FEARS T R | 2000 | Br J Cancer2000，82，11： | 1 |
| 16 | Recent trends in breast cancer incidence and mortality显示文摘 | Lacey J V Jr Devesa S S Brinton L A | 2002 | Environ Mol Mutagen2002，39，23： | 1 |
| 17 | Global increases in kidney cancer incidence, 1973-1992 显示文摘 | Mathew A Devesa S S Fraumeni J F Jr Chow W H | 2002 | Eur J Cancer Prey2002，11，： | 1 |
| 18 | The role of motivation in visitor satisfaction: Empirical evidence in rural tourism显示文摘 | Devesa Mar i a Laguna Marta Andr 6 s Palacios | 2010 | Tourism Management2010，4，31： | 1 |
| 19 | Conservative manage- ment of hernia mesh infection 显示文摘 | RUIZ-TOVAR J REY A DEVESA J M | 2011 | Rev Gastroenterol Peru2011，31，4： | 1 |
| 20 | International trends and patterns of prostate cancer incidence and mortality显示文摘 | Hsing A W Tsao L Devesa S S | 2000 | Int J Cancer2000，85，1： | 1 |
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