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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Cobalt,a reactive metal in releasing hydrogen from sodium borohydride by hydrolysis:A short review and a research perspective显示文摘Cobalt is commonly admitted as being a promising catalyst in accelerating NaBH4 hydrolysis,being as reactive as noble metals and much more cost-effective.This is the topic of the present paper.Herein,we survey(i) the NaBH4-devoted literature while especially focusing on the Co catalysts and(ii) our work on the same topic.Finally,we report(iii) reactivity results of newly developed Co-based catalysts.From both surveys,it mainly stands out that Co has been investigated as catalysts in various forms:namely,as chlorides,reduced nanoparticles(metal Co,Co boride,Co-B alloy),supported over supports and shaped.In doing so the reactivity can be easily varied achieving H2 generation rates from few to >1000 L(H2)/min·g(metal).Nevertheless,our work can be distinguished from the NaBH4 literature.Indeed,we are working on strategies that focus on making alternative Co-based catalysts.One of these strategies is illustrated here as we report new reactivity data of Co-based bimetallic supported catalysts.For example,we show that 20 wt% Co90Y10/γAl2O3-20 wt% Co95Hf5/γAl2O3 > 20 wt% Co99Zr1/γAl2O3 > 20 wt% Co/γAl2O3,the best catalysts showing HGRs of about 245 mL(H2)/min or 123 L(H2) /min·g(metals). | DEMIRCI Umit B AKDIM Ouardia HANNAUER Julien CHAMOUN Rita MIELE Philippe | 2010 | Science China Chemistry2010，53，9： | 3 |
| 3 | Normal gestations and live births after orthotopic autograft of vitrified - warmed hemi - ovaries into ewes显示文摘 | Bordes A Lomage J Demirci B | 2005 | Human Reproduction2005，20，10： | 1 |
| 4 | Restoration of ovarian steroid secretion and histologic assessment after freezing, thawing, and autograft of a hemi-ovary in sheep 显示文摘 | Salle B Lornage J Demirci B | 1999 | Fertil Steril1999，72，2： | 1 |
| 5 | Ru-based bimetallic alloys for hydrogen generation by hydrolysis of sodium terahydroborate显示文摘 | Demirci U B Garin F | 2008 | Journal of Alloys and Compounds2008，463，12： | 1 |
| 6 | Ten-year efforts and a no-go recommendation for sodium borohydride for on-board automotive hydrogen storage显示文摘 | DEMIRCI U B AKDIM O MIELE P | 2009 | Int J Hydrogen Energy2009，74，： | 1 |
| 7 | Evaluation of the inferior turbinate in patients with deviated nasal septum by using computed tomography显示文摘 | Egeli E Demirci 1 Yazycy B | | 0，，01： | 1 |
| 8 | Follicular viability and morphology of sheep ovaries after exposure to cryoprotectant and cryopreservation with different freezing protocols 显示文摘 | Demirci B Lornage J Salle B | 2001 | Fertil Steril2001，75，4： | 1 |
| 9 | Kinetic study of n-heptane conversion on sulfated zirconia-supported platinum catalyst:The metal-proton adduct is the active site显示文摘 | DEMIRCI U B GARIN F | 2002 | J Mol Catal2002，188，12： | 1 |
| 10 | Observation of bacteria and fungi in infected root canals and dentinal tubules by SEM显示文摘 | Sen BH Piskin B Demirci T | | 0，，1： | 1 |
| 11 | Differentialeffects of TGF - β on connective tissue growth factor ( CTGF /CCN2) expression in hepatic stellate cells and hepatocytes显示文摘 | GRESSNER OA LAHME B DEMIRCI I | 2007 | JHepatol2007，47，5： | 1 |
| 12 | Fatty acid composition of seed oils of twelve Salvia species growing in Turkey 显示文摘 | AZCAN N ERTAN A DEMIRCI B | 2004 | Chemistry of Natural Compounds2004，40，3： | 1 |
| 13 | Antibacterial activity of two Phlomis essential oils against food pathogens显示文摘 | Demirci F Guven K Demirci B | 2008 | Food Control2008，19，： | 1 |
| 14 | Observation of bacteri- a and fungi in infected rootcanals and dentinal tubules by SEM显示文摘 | Sen B H Piskin B Demirci T | 1995 | Endod Dent Traumatol1995，11，1： | 1 |
| 15 | Morphological al-terations and DNA fragmentation in oocytes from primor-dial and primary follicles after freezing-thaw ing of ovariancortex in sheep显示文摘 | Demirci B Salle B Frappart L | 2002 | Fertil Steril2002，77，3： | 1 |
| 16 | The theoretical and experimental investigation of blank holder forces plate effect in deep drawing process of AL 1050 material 显示文摘 | H Ibrahim Demirci Mustafa Y Kemal Demiray b | 2008 | Materials and Design2008，29，： | 1 |
| 17 | Spastic paraparesis asso- ciated with porta显示文摘 | Demirci M Tan E Elibol B | 1992 | Neurology1992，42，5： | 1 |
| 18 | Cobalt (Ⅱ) salts, performing materials for generating hydrogen from sodium borohydride显示文摘 | AKDIM O DEMIRCI U B MULLER D | 2009 | International Journal of Hydrogen Energy2009，34，6： | 1 |
| 19 | Analysis of the volatile components of five turkish Rhododendron species by headspace solidphase microextraction and GC-MS (HS-SPMEGC-MS)显示文摘 | TASDEMIR D DEMIRCI B DEMIRCI F | 2003 | Zeitschrift Fur Naturforschung C2003，58，： | 1 |
| 20 | Cobalt in NaBH4 hydrolysis 显示文摘 | DEMIRCI U B MIELE P | 2010 | Physical Chemistry Chemical Physics2010，12，14： | 1 |
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