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| 1 | Evaluation of immunogenicity and reactogenicity of recombinant DNA hepatitis B vaccine produced in India显示文摘AIM: (1) To gain information on immune responses to an accelerated schedule of 0, 1, and 2 mo in paramedical staff and BDS students who are at an increased risk of getting hepatitis B infection and come under high risk groups. (2) To assess the efficacy and safety of EnivacHB in different age groups, using genetically modified yeast strain Pichia pastoris, a new recombinant hepatitis B vaccine developed and manufactured in India.METHODS: A prospective, comparative, and single blinded trial of rapid (0, 1, and 2 mo) hepatitis B immunization schedulewas reported. A total of three hundred and seven (212 females and 95 males) healthy volunteers divided into three age groups (18-29, 30-39,and 40-49) were enrolled after screening for markers of hepatitis B. All the volunteers received 20 mg of the vaccine intramuscularly at 0, 1, and 2 mo.RESULTS: Geometric mean titers were calculated pre and post vaccination. Before immunization the GMT was 0.0124 mIU/mL. One month after the administration of the third dose of recombinant vaccine 296/307 (96.5%)subjects achieved seroprotective levels of anti-HBs. The geometric mean anti-HBs titers achieved after one month of the third dose was 2 560.0 mIU/mL. The geometric mean anti-HBs titer of males was 2 029.0 mIU/mL, while that of the females was 2 759.0 mIU/mL. In the age group of 18-29 years, anti-HBs titer was 3 025.0 mIU/mL, while that in the age group of 30-39 years was 2096.0 mIU/mL. In third age group of 40-49 years, antiHBs titer was 1 592.0 mIU/mL. Hyper-responses (antiHBs≥100 mIU/mL) were shown in 88.0% (271/307) of subjects. Eleven (3.5%) subjects responded poorly to the vaccine in the age group of 40-49 years. There was only mild pain at the site of injection otherwise there were no other adverse drug reactions (ADRs).CONCLUSION: This vaccine (Enivac-HB) is safe and efficacious, providing significant protection after the third dose and rapid hepatitis B immunization schedule of 0, 1, and 2 mo can be recommended whenever rapid protection is the goal. | Zahid Hussain Syed S Ali Syed A Husain Mohammad Raish Deepika R Sharma Premashis Kar | 2005 | World Journal of Gastroenterology2005，11，45： | 3 |
| 2 | Successful pregnancy following medical management of heterotopic pregnancy显示文摘 | Lavanya R Deepika K Patti M | 2009 | J Hum Reprod Sci2009，2，1： | 1 |
| 3 | Successful pregnancy follow- ing medical management of heterotopic pregnancy显示文摘 | Lavanya R Deepika K Patil M | 2009 | J Hum Re- prod Sci2009，2，1： | 1 |
| 4 | Studies on the antibacterial activity potential of commonly used food preservatives显示文摘 | Anoop Kumar Shee Balaji R Raja Deepika Sethi | 2010 | International Journal of Engi- neering Science and Technology2010，2，3： | 1 |
| 5 | Characterization of native oxide film on amorphous Co66Si16B12Fe4Mo2 by X-ray photoelectron spectroscopy显示文摘 | JAIN R DEEPIKA B ANIL D | 2010 | Journal of Alloys and Compounds2010，490，12： | 1 |
| 6 | Successful pregnancy following medical management of heterotopic pregnancy显示文摘 | LAVANYA R DEEPIKA K PATIL M | 2009 | J Hum Reprod Sci2009，2，1： | 1 |
| 7 | The impactof intraoperative autologous blood transfusion during type IIIradical hysterectomy for early-stage cervical cancer 显示文摘 | Mirhashemi R Averette HE Deepika K | 1999 | AmJ Obstet Gynecol1999，181，： | 1 |
| 8 | Inspection of vulnerabilities through attack graphs and analyzing security metrics used for measuring securi- ty in a network显示文摘 | Dhaya R Deepika D | 2014 | International Journal of Innovative Re search in Computer and Communication Engineering2014，2，1： | 1 |
| 9 | Successful pregnancy follow-ing medical management of heterotopic pregnancy显示文摘 | Lavanya R Deepika K Patil M | 2009 | J Hum Reprod Sci2009，2，1： | 1 |
| 10 | Successful pregnancy following medical management of heterotopic pregnancy 显示文摘 | Lavanva R Deepika K Patil M | 2009 | J Hum Reprod2009，2，1： | 1 |
| 11 | Efficient regeneration of pla- ntlets from callus and mesophyll derived protoplasts of Robinia pseudoacacia L显示文摘 | Kanwar K Bhardwaj A Deepika R | 2009 | Plant Cell Tissue and Organ Culture2009，96，1： | 1 |
| 12 | Efficient regeneration of plantlets from callus and mesophyll derived protoplasts of Robinia pseudoacacia L显示文摘 | Kanwar K Bhardwaj A Deepika R | 2009 | Plant Cell Tiss Organ Cult2009，96，： | 1 |
| 13 | Successful pregnancy following medical management of heterotopic pregnancy显示文摘 | Lavanva R Deepika K Patil M | | 0，，1： | 1 |
| 14 | Battered women's career decision-making self-efficacy: further insights and contributing factors 显示文摘 | CHRIS B DEEPIKA R FOUNTAIR J JOHNSON A | 2000 | Journal of Career Assessment2000，8，3： | 1 |
| 15 | Effectiveness of two flavored topical anesthetic agents in reducing injection pain in children: a comparative study显示文摘 | Deepika A Rao C R Vinay C | 2012 | J Clin Pediatr Dent2012，37，1： | 1 |
| 16 | Effect of growth time on the surface and adhesion properties of Lactobacillus rhamno- sus GG显示文摘 | Deepika G Green R J Frazier R A | 2009 | J Appl Mierobiol2009，107，4： | 1 |
| 17 | SP- A is necessary for increased clearance of alveolar DPPC with hyperventilation or secretagogues 显示文摘 | Deepika Jain Chandra Dodia Sandra R | 2003 | Am J Physiol Lung Cell Mol Physiol2003，284，15： | 1 |
| 18 | Comparison of in vitro regeneration pathways in Punica granatum L显示文摘 | Kanwar K Joseph J Deepika R | 2010 | Plant Cell Tissue and Organ Culture2010，100，2： | 1 |
| 19 | Effect of growth time on the surface and adhesion properties of Lactobacillus rhamnosus GG 显示文摘 | Deepika G Green R J Frazier R A | 2009 | Journal of Applied Microbiology2009，107，4： | 1 |
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