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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Reperfusion therapy in elderly patients with acute myocardial infarction: a randomized comparison of primary angioplasty and thrombolytic therapy 显示文摘	de Boer M J Ottervanger J P vant Hof A W	2002	J Am Coil Cardiol2002，39，11：	1
3	Analysis of ammonia-oxidizing bacteria of the 13 subdivision of the class Pro- teobacteria in coastal sand dunes by denaturing gradient gel electro- pboresis and sequencing of PCR-amplified 16S ribosomal DNA frag- ments 显示文摘	KOWALCHUK G A STEPHEN J R DE BOER W	1997	Appl Environ Microbiol1997，63，4：	1
4	Nitrification in acid soils: microorganisms and mechanisms显示文摘	De Boer W Kowalchuk G A	2001	Soil Biol Biochem2001，33，：	1
5	Microbial community composition affects soil fungistasis显示文摘	De Boer W Verheggen P Klein Gunnewiek P J A	2003	Appl Environ Microbiol2003，69，：	1
6	The reduction and 0xidation behavior of manganese oxides显示文摘	de Boer B A Geuis J W	1999	Catal Today1999，47，：	1
7	Telomere biology in healthy aging and disease显示文摘	Oeseburg H de Boer R A van Gilst W H van der Harst P	2010	Pflugers Arch2010，459，：	1
8	Managing organizational knowledge integration in the emerging multimedia complex 显示文摘	De Boer M Van den Bosch Frans A J Volberda H W	1999	Journal of Management Studies1999，36，3：	1
9	Phylogeny-function analysis of (meta)genomic libraries: screening for expression of ribosomal RNA genes by large-insert library fluorescent in situ hybridisation (LIL-FISH) 显示文摘	Leveau J H J Gerards S de Boer W	2004	Environ Microbiol2004，6，9：	1
10	One-dimensional transient wave propagation in fluid-saturated incompressible porous media 显示文摘	DE BOER R EHLERS W LIU Z	1993	Archive of Applied Mechanics1993，63，：	1
11	A hy- perspectral band selector for plant species discrimination 显示文摘	Vaiphasa C Skidmore A K de Boer W F	2007	ISPRS Journal of Photogrammetry and Remote Sensing2007，62，3：	1
12	Exploring preserved fossil dinoflagellate and haptophyte DNA signa- tures to infer ecological and environmental changes during deposition of sapropel S1 in the eastern Mediterranean显示文摘	Boere A C Rijpstra W I C de Lange G J	2011	Paleoceanography2011，26，2：	1
13	Psychological distress in chronic craniomandibular and cervical spinal pain patients显示文摘	Visscher CM Lobbezoo F de Boer W	2001	Oral Sci2001，109，3：	1
14	Analysis of ammonia-oxidizing bacteria of the β subdivision of the class Proteobacteria in coastal sand dunes by denaturing gradient gel electrophoresis and sequencing of PCR amplified 16S ribosomal DNA fragments显示文摘	KOWALCHUK G A STEPHEN J DE BOER W	1997	Appl Environ Microbiol1997，6，：	1
15	Dry powder inhalers for pulmonary drug delivery显示文摘	Frijlink H W De Boer A H	2004	Expert Opin Drug Deliv2004，1，1：	1
16	The bacterial genus Collimonas: mycophagy, weathering and other adaptive solutions to life in oligotrophic soil environments 显示文摘	Leveau JH Uroz S de Boer W	2010	Environ Microbiol2010，12，2：	1
17	Monocyte chemoattractant protein 1, interleukin 8, and chronic airways inflammation in COPD显示文摘	DE BOER W I SONT J K VAN SCHADEWIJK A	2000	J Pathol2000，190，5：	1
18	Intestinal mucinous substances in gastric intesinal metaplasia and Carcinoma studied by immunoflurescence 显示文摘	Ma J De Boer W G R M Nayman J	1982	Cancer1982，49，：	1
19	Metaanalysis:The influence of pre-treatment with a proton pump inhibitor on Helicobcacter pylori eradication显示文摘	Janssen M J Laheij R J de Boer W A	2005	Aliment Pharmacol Ther2005，21，：	1
20	Dopamine release in the prefrontal cortex in response to memantine following sub-chronic NMDA receptor blockade with memantine:a microdialysis study in rats显示文摘	Hesselink MB De Boer AG Breimer DD Danysz W		0，，09：	1

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